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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4A98

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoflurazepam

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
F0004888molecular_functiontransmembrane signaling receptor activity
F0005216molecular_functionmonoatomic ion channel activity
F0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
F0006811biological_processmonoatomic ion transport
F0016020cellular_componentmembrane
F0034220biological_processmonoatomic ion transmembrane transport
G0004888molecular_functiontransmembrane signaling receptor activity
G0005216molecular_functionmonoatomic ion channel activity
G0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
G0006811biological_processmonoatomic ion transport
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
H0004888molecular_functiontransmembrane signaling receptor activity
H0005216molecular_functionmonoatomic ion channel activity
H0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
H0006811biological_processmonoatomic ion transport
H0016020cellular_componentmembrane
H0034220biological_processmonoatomic ion transmembrane transport
I0004888molecular_functiontransmembrane signaling receptor activity
I0005216molecular_functionmonoatomic ion channel activity
I0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
I0006811biological_processmonoatomic ion transport
I0016020cellular_componentmembrane
I0034220biological_processmonoatomic ion transmembrane transport
J0004888molecular_functiontransmembrane signaling receptor activity
J0005216molecular_functionmonoatomic ion channel activity
J0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
J0006811biological_processmonoatomic ion transport
J0016020cellular_componentmembrane
J0034220biological_processmonoatomic ion transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE BFZ A 1318
ChainResidue
AGLU131
EASN103
EGLU150
APHE133
ATYR175
AHIS177
ASER180
EPHE19
EVAL40
EARG91
EILE101
site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BFZ B 1318
ChainResidue
APHE19
ATYR38
AVAL40
AASN103
AGLU150
BTYR175
BHIS177
BSER180
BGLN182
site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BFZ C 1318
ChainResidue
BPHE19
BTYR38
BVAL40
BGLU150
CTYR175
CHIS177
CSER180
CVAL181
CGLN182
site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BFZ D 1318
ChainResidue
CPHE19
CTYR38
CVAL40
CASN103
CGLU150
DTYR175
DHIS177
DSER180
DGLN182
site_idAC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE BFZ E 1318
ChainResidue
DPHE19
DVAL40
DMET93
DASN103
DGLU150
ETYR175
EHIS177
ESER180
EVAL181
EGLN182
site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BFZ F 1318
ChainResidue
FTYR175
FHIS177
FSER180
FVAL181
FGLN182
JPHE19
JTYR38
JASN103
JGLU150
site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE BFZ G 1318
ChainResidue
FPHE19
FVAL40
FARG91
FASN103
FGLU150
GPHE133
GTYR175
GHIS177
GSER180
GGLN182
site_idAC8
Number of Residues12
DetailsBINDING SITE FOR RESIDUE BFZ H 1318
ChainResidue
GPHE19
GTYR38
GVAL40
GARG91
GASN103
GGLU150
HGLU131
HPHE133
HTYR175
HHIS177
HSER180
HGLN182
site_idAC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BFZ I 1318
ChainResidue
HPHE19
HTYR38
HVAL40
HGLU150
ITYR175
IHIS177
ISER180
IGLN182
site_idBC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BFZ J 1318
ChainResidue
IPHE19
ITYR38
IVAL40
IGLU150
JTYR175
JHIS177
JSER180
JGLN182
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues600
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues220
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues90
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsMotif: {"description":"Cys-loop"}
ChainResidueDetails

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PDB entries from 2025-07-23

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