Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4A98

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromoflurazepam

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BFZ A 1318

Chain	Residue
A	GLU131
E	ASN103
E	GLU150
A	PHE133
A	TYR175
A	HIS177
A	SER180
E	PHE19
E	VAL40
E	ARG91
E	ILE101

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BFZ B 1318

Chain	Residue
A	PHE19
A	TYR38
A	VAL40
A	ASN103
A	GLU150
B	TYR175
B	HIS177
B	SER180
B	GLN182

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BFZ C 1318

Chain	Residue
B	PHE19
B	TYR38
B	VAL40
B	GLU150
C	TYR175
C	HIS177
C	SER180
C	VAL181
C	GLN182

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BFZ D 1318

Chain	Residue
C	PHE19
C	TYR38
C	VAL40
C	ASN103
C	GLU150
D	TYR175
D	HIS177
D	SER180
D	GLN182

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BFZ E 1318

Chain	Residue
D	PHE19
D	VAL40
D	MET93
D	ASN103
D	GLU150
E	TYR175
E	HIS177
E	SER180
E	VAL181
E	GLN182

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BFZ F 1318

Chain	Residue
F	TYR175
F	HIS177
F	SER180
F	VAL181
F	GLN182
J	PHE19
J	TYR38
J	ASN103
J	GLU150

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BFZ G 1318

Chain	Residue
F	PHE19
F	VAL40
F	ARG91
F	ASN103
F	GLU150
G	PHE133
G	TYR175
G	HIS177
G	SER180
G	GLN182

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BFZ H 1318

Chain	Residue
G	PHE19
G	TYR38
G	VAL40
G	ARG91
G	ASN103
G	GLU150
H	GLU131
H	PHE133
H	TYR175
H	HIS177
H	SER180
H	GLN182

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BFZ I 1318

Chain	Residue
H	PHE19
H	TYR38
H	VAL40
H	GLU150
I	TYR175
I	HIS177
I	SER180
I	GLN182

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BFZ J 1318

Chain	Residue
I	PHE19
I	TYR38
I	VAL40
I	GLU150
J	TYR175
J	HIS177
J	SER180
J	GLN182

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	600
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU205-LEU225
D	LEU205-LEU225
D	THR234-PRO254
D	MET265-HIS285
E	LEU205-LEU225
E	THR234-PRO254
E	MET265-HIS285
F	LEU205-LEU225
F	THR234-PRO254
F	MET265-HIS285
G	LEU205-LEU225
A	THR234-PRO254
G	THR234-PRO254
G	MET265-HIS285
H	LEU205-LEU225
H	THR234-PRO254
H	MET265-HIS285
I	LEU205-LEU225
I	THR234-PRO254
I	MET265-HIS285
J	LEU205-LEU225
J	THR234-PRO254
A	MET265-HIS285
J	MET265-HIS285
B	LEU205-LEU225
B	THR234-PRO254
B	MET265-HIS285
C	LEU205-LEU225
C	THR234-PRO254
C	MET265-HIS285

site_id	SWS_FT_FI2
Number of Residues	220
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	GLU226-GLN233
E	ARG286-ARG301
F	GLU226-GLN233
F	ARG286-ARG301
G	GLU226-GLN233
G	ARG286-ARG301
H	GLU226-GLN233
H	ARG286-ARG301
I	GLU226-GLN233
I	ARG286-ARG301
J	GLU226-GLN233
A	ARG286-ARG301
J	ARG286-ARG301
B	GLU226-GLN233
B	ARG286-ARG301
C	GLU226-GLN233
C	ARG286-ARG301
D	GLU226-GLN233
D	ARG286-ARG301
E	GLU226-GLN233

site_id	SWS_FT_FI3
Number of Residues	90
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	ARG255-GLN264
J	ARG255-GLN264
B	ARG255-GLN264
C	ARG255-GLN264
D	ARG255-GLN264
E	ARG255-GLN264
F	ARG255-GLN264
G	ARG255-GLN264
H	ARG255-GLN264
I	ARG255-GLN264

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)