4A94
Structure of the carboxypeptidase inhibitor from Nerita versicolor in complex with human CPA4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004181 | molecular_function | metallocarboxypeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| C | 0010951 | biological_process | negative regulation of endopeptidase activity |
| C | 0030414 | molecular_function | peptidase inhibitor activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| D | 0010951 | biological_process | negative regulation of endopeptidase activity |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | HIS69 |
| A | GLU72 |
| A | HIS196 |
| D | ALA53 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 A 1309 |
| Chain | Residue |
| A | TYR248 |
| A | GLU270 |
| D | ALA53 |
| A | HIS69 |
| A | ARG127 |
| A | ASN144 |
| A | ARG145 |
| A | HIS196 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 1310 |
| Chain | Residue |
| A | ARG71 |
| A | LEU125 |
| A | TRP126 |
| A | ARG127 |
| A | LYS128 |
| A | HOH2094 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 501 |
| Chain | Residue |
| B | HIS69 |
| B | GLU72 |
| B | HIS196 |
| C | ALA53 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B 1309 |
| Chain | Residue |
| B | HIS69 |
| B | ARG127 |
| B | ASN144 |
| B | ARG145 |
| B | TYR248 |
| B | GLU270 |
| C | ALA53 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 B 1310 |
| Chain | Residue |
| B | LEU125 |
| B | TRP126 |
| B | ARG127 |
| B | LYS128 |
| B | GLU163 |
| B | HOH2035 |
| B | HOH2039 |
| C | GLN39 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 C 1054 |
| Chain | Residue |
| B | ASN159 |
| B | CYS161 |
| C | ARG7 |
| C | ILE10 |
| C | PHE25 |
| C | HIS40 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 D 1054 |
| Chain | Residue |
| A | ASN159 |
| A | CYS161 |
| D | ARG7 |
| D | CYS9 |
| D | ILE10 |
| D | PHE25 |
| D | HIS40 |
Functional Information from PROSITE/UniProt
| site_id | PS00132 |
| Number of Residues | 23 |
| Details | CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaVwLnaGiHSrEwISQataiwT |
| Chain | Residue | Details |
| A | PRO60-THR82 |
| site_id | PS00133 |
| Number of Residues | 11 |
| Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLmYPY |
| Chain | Residue | Details |
| A | HIS196-TYR206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22294694 |
| Chain | Residue | Details |
| C | ALA53 | |
| D | ALA53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23746805, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | ASN7 | |
| B | SER13 | |
| B | LYS85 | |
| B | ASP158 | |
| A | TYR11 | |
| A | HIS12 | |
| A | SER13 | |
| A | LYS85 | |
| A | ASP158 | |
| B | ASN7 | |
| B | TYR11 | |
| B | HIS12 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17506531, ECO:0007744|PDB:2PCU |
| Chain | Residue | Details |
| A | GLU15 | |
| A | PHE51 | |
| A | ARG84 | |
| B | GLU15 | |
| B | PHE51 | |
| B | ARG84 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:15738388, ECO:0000269|PubMed:16091843, ECO:0000269|PubMed:17506531, ECO:0000269|PubMed:22294694, ECO:0000269|PubMed:23746805, ECO:0007744|PDB:2BO9, ECO:0007744|PDB:2BOA, ECO:0007744|PDB:2PCU, ECO:0007744|PDB:4A94, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | HIS69 | |
| A | GLU72 | |
| A | HIS196 | |
| B | HIS69 | |
| B | GLU72 | |
| B | HIS196 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17506531, ECO:0000269|PubMed:23746805, ECO:0007744|PDB:2PCU, ECO:0007744|PDB:4BD9 |
| Chain | Residue | Details |
| A | SER136 | |
| B | SER136 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15738388, ECO:0000269|PubMed:16091843, ECO:0000269|PubMed:17506531, ECO:0007744|PDB:2BO9, ECO:0007744|PDB:2BOA, ECO:0007744|PDB:2PCU |
| Chain | Residue | Details |
| A | ASN148 | |
| B | ASN148 |
