Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4A8P

Crystal structure of putrescine transcarbamylase from Enterococcus faecalis with N5-(phosphonoacetyl)-L-ornithine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006591	biological_process	ornithine metabolic process
A	0006596	biological_process	polyamine biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0033388	biological_process	putrescine biosynthetic process from arginine
A	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
A	0050231	molecular_function	putrescine carbamoyltransferase activity
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006591	biological_process	ornithine metabolic process
B	0006596	biological_process	polyamine biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0033388	biological_process	putrescine biosynthetic process from arginine
B	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0050231	molecular_function	putrescine carbamoyltransferase activity
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006591	biological_process	ornithine metabolic process
C	0006596	biological_process	polyamine biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0033388	biological_process	putrescine biosynthetic process from arginine
C	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0050231	molecular_function	putrescine carbamoyltransferase activity
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006591	biological_process	ornithine metabolic process
D	0006596	biological_process	polyamine biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0033388	biological_process	putrescine biosynthetic process from arginine
D	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0050231	molecular_function	putrescine carbamoyltransferase activity
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006591	biological_process	ornithine metabolic process
E	0006596	biological_process	polyamine biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0033388	biological_process	putrescine biosynthetic process from arginine
E	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0050231	molecular_function	putrescine carbamoyltransferase activity
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006591	biological_process	ornithine metabolic process
F	0006596	biological_process	polyamine biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0033388	biological_process	putrescine biosynthetic process from arginine
F	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
F	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0050231	molecular_function	putrescine carbamoyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PAO A 1340

Chain	Residue
A	SER52
A	ARG297
A	HOH2094
A	HOH2095
A	HOH2097
A	HOH2128
A	HOH2129
B	GLN79
A	THR53
A	ARG54
A	THR55
A	ARG103
A	HIS130
A	GLN164
A	ASP227
A	LEU270

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PAO B 1340

Chain	Residue
B	SER52
B	THR53
B	ARG54
B	THR55
B	ARG103
B	MET125
B	HIS130
B	THR163
B	GLN164
B	VAL165
B	ASP227
B	LEU270
B	ARG297
B	HOH2079
B	HOH2111
B	HOH2112
C	GLN79

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAO C 1340

Chain	Residue
A	GLN79
C	SER52
C	THR53
C	ARG54
C	THR55
C	ARG103
C	HIS130
C	GLN164
C	VAL165
C	ASP227
C	LEU270
C	ARG297
C	HOH2075

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PAO D 1340

Chain	Residue
D	SER52
D	THR53
D	ARG54
D	THR55
D	ARG103
D	MET125
D	HIS130
D	GLN164
D	ASP227
D	LEU270
D	ARG297

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PAO E 1338

Chain	Residue
E	SER52
E	THR53
E	ARG54
E	THR55
E	ARG103
E	HIS130
E	GLN164
E	ASP227
E	LEU270
E	ARG297

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAO F 1340

Chain	Residue
F	SER52
F	THR53
F	ARG54
F	THR55
F	ARG103
F	HIS130
F	THR163
F	GLN164
F	VAL165
F	ASP227
F	LEU270
F	ARG297
F	HOH2049

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 1341

Chain	Residue
A	HIS69
A	HOH2046
A	HOH2050
A	HOH2130
B	HIS69
C	HIS69

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI D 1341

Chain	Residue
D	HIS69
D	HOH2049
E	HIS69
F	HIS69

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS C 1341

Chain	Residue
C	ASP161
C	ALA162
C	PHE188
C	GLY231

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS B 1341

Chain	Residue
B	ASP161
B	ALA162
B	LEU232
B	HOH2113

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Important for structural integrity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)