4A8M

Non-Catalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial dsRNA virus phi6 from De Novo Initiation to Elongation

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000166	molecular_function	nucleotide binding
P	0001172	biological_process	RNA-templated transcription
P	0003723	molecular_function	RNA binding
P	0003968	molecular_function	RNA-directed RNA polymerase activity
P	0006351	biological_process	DNA-templated transcription
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0019079	biological_process	viral genome replication
P	0034062	molecular_function	5'-3' RNA polymerase activity
P	0039694	biological_process	viral RNA genome replication
P	0044423	cellular_component	virion component
P	0046872	molecular_function	metal ion binding
P	0050265	molecular_function	RNA uridylyltransferase activity
Q	0000166	molecular_function	nucleotide binding
Q	0001172	biological_process	RNA-templated transcription
Q	0003723	molecular_function	RNA binding
Q	0003968	molecular_function	RNA-directed RNA polymerase activity
Q	0006351	biological_process	DNA-templated transcription
Q	0016740	molecular_function	transferase activity
Q	0016779	molecular_function	nucleotidyltransferase activity
Q	0019079	biological_process	viral genome replication
Q	0034062	molecular_function	5'-3' RNA polymerase activity
Q	0039694	biological_process	viral RNA genome replication
Q	0044423	cellular_component	virion component
Q	0046872	molecular_function	metal ion binding
Q	0050265	molecular_function	RNA uridylyltransferase activity
R	0000166	molecular_function	nucleotide binding
R	0001172	biological_process	RNA-templated transcription
R	0003723	molecular_function	RNA binding
R	0003968	molecular_function	RNA-directed RNA polymerase activity
R	0006351	biological_process	DNA-templated transcription
R	0016740	molecular_function	transferase activity
R	0016779	molecular_function	nucleotidyltransferase activity
R	0019079	biological_process	viral genome replication
R	0034062	molecular_function	5'-3' RNA polymerase activity
R	0039694	biological_process	viral RNA genome replication
R	0044423	cellular_component	virion component
R	0046872	molecular_function	metal ion binding
R	0050265	molecular_function	RNA uridylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GTP R 1665

Chain	Residue
R	ARG81
R	GLU529
R	ASN626
R	TYR630
R	MG1666
R	ATP1667
R	ARG204
R	GLN206
R	ARG270
R	ASP454
R	GLU491
R	ALA495
R	LEU497
R	GLY498

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG R 1666

Chain	Residue
R	ASP454
R	GLU491
R	ALA495
R	GTP1665

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG P 1665

Chain	Residue
P	ASP454
P	GLU491
P	ALA495

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG Q 1665

Chain	Residue
Q	ASP454
Q	GLU491
Q	ALA495
Q	GTP1666

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GTP P 1666

Chain	Residue
P	ARG81
P	ARG204
P	ARG270
P	ASP454
P	GLU491
P	ALA495
P	PHE496
P	LEU497
P	GLY498
P	ATP1667

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ATP P 1667

Chain	Residue
P	LYS223
P	ARG225
P	ARG270
P	GTP1666

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTP Q 1666

Chain	Residue
Q	ARG81
Q	ARG270
Q	ASP454
Q	GLU491
Q	ALA495
Q	LEU497
Q	GLY498
Q	SER520
Q	GLU529
Q	ASN626
Q	TYR630
Q	MG1665

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ATP Q 1667

Chain	Residue
Q	ARG225
Q	ARG268
Q	ARG270
Q	VAL325
Q	ASP327
Q	HIS328

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ATP R 1667

Chain	Residue
R	ARG225
R	ARG268
R	ARG270
R	ASP327
R	GTP1665

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	525
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

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