4A5O

Crystal structure of Pseudomonas aeruginosa N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0009086	biological_process	methionine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0035999	biological_process	tetrahydrofolate interconversion
B	0000105	biological_process	histidine biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
B	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0009086	biological_process	methionine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0035999	biological_process	tetrahydrofolate interconversion
C	0000105	biological_process	histidine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
C	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0009086	biological_process	methionine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016787	molecular_function	hydrolase activity
C	0035999	biological_process	tetrahydrofolate interconversion
D	0000105	biological_process	histidine biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
D	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0009086	biological_process	methionine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016787	molecular_function	hydrolase activity
D	0035999	biological_process	tetrahydrofolate interconversion

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1285

Chain	Residue
A	LEU137
A	ARG139
A	LYS144
A	ASN274

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 1286

Chain	Residue
A	ALA151
A	ALA155
A	LEU157
A	TYR158
A	GLY182

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Functional Information from PROSITE/UniProt

site_id	PS00766
Number of Residues	26
Details	THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. QdDLLalIdrLNdDpaidgILVQLPL

Chain	Residue	Details
A	GLN76-LEU101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01576

Chain	Residue	Details
A	GLY166
A	ILE232
B	GLY166
B	ILE232
C	GLY166
C	ILE232
D	GLY166
D	ILE232

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