4A3Q
The 2.15 Angstrom resolution crystal structure of Staphylococcus aureus alanine racemase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006522 | biological_process | alanine metabolic process |
| A | 0008784 | molecular_function | alanine racemase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030632 | biological_process | D-alanine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006522 | biological_process | alanine metabolic process |
| B | 0008784 | molecular_function | alanine racemase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PLP A 1039 |
| Chain | Residue |
| A | LYS39 |
| A | HOH2032 |
| A | TYR43 |
| A | HIS168 |
| A | ASN203 |
| A | SER204 |
| A | ARG219 |
| A | GLY221 |
| A | ILE222 |
| A | TYR354 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1383 |
| Chain | Residue |
| A | TYR228 |
| A | GLN234 |
| A | HIS240 |
| A | LEU241 |
| A | ARG336 |
| A | HOH2118 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1384 |
| Chain | Residue |
| A | SER107 |
| A | LYS108 |
| A | GLN109 |
| A | THR146 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1385 |
| Chain | Residue |
| A | VAL48 |
| A | LYS49 |
| A | ARG52 |
| A | HIS76 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1386 |
| Chain | Residue |
| A | HIS335 |
| A | ARG336 |
| A | GLU337 |
| A | HOH2138 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1387 |
| Chain | Residue |
| A | HIS29 |
| A | PRO30 |
| A | ASN31 |
| A | LYS32 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1388 |
| Chain | Residue |
| A | LYS131 |
| A | ARG138 |
| A | LEU139 |
| A | HIS168 |
| A | HOH2080 |
| B | GLN314 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 1389 |
| Chain | Residue |
| A | CYS311 |
| A | MET312 |
| A | HOH2135 |
| B | LYS39 |
| B | PLP1039 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PLP B 1039 |
| Chain | Residue |
| A | ACT1389 |
| B | LYS39 |
| B | TYR43 |
| B | HIS168 |
| B | SER204 |
| B | ARG219 |
| B | GLY221 |
| B | ILE222 |
| B | TYR354 |
| B | HOH2015 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1383 |
| Chain | Residue |
| B | TYR228 |
| B | GLN234 |
| B | HIS240 |
| B | LEU241 |
| B | ARG336 |
| B | HOH2067 |
| B | HOH2076 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1384 |
| Chain | Residue |
| B | LYS49 |
| B | ARG52 |
| B | HIS76 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1385 |
| Chain | Residue |
| A | SER361 |
| A | ARG362 |
| A | HOH2152 |
| B | LEU360 |
| B | SER361 |
| B | ARG362 |
| B | HOH2105 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1386 |
| Chain | Residue |
| B | SER107 |
| B | LYS108 |
| B | GLN109 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1387 |
| Chain | Residue |
| B | HIS335 |
| B | ARG336 |
| B | GLU337 |
| B | HOH2096 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1388 |
| Chain | Residue |
| A | LYS108 |
| A | LYS112 |
| B | HIS29 |
| B | PRO30 |
| B | ASN31 |
| B | LYS32 |
| B | ASP211 |
| B | GLN213 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1389 |
| Chain | Residue |
| B | LYS131 |
| B | ARG138 |
| B | LEU139 |
| B | HIS168 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 1390 |
| Chain | Residue |
| A | LYS39 |
| A | TYR354 |
| B | TYR284 |
| B | CYS311 |
| B | MET312 |
| B | HOH2078 |
| B | HOH2091 |
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGLG |
| Chain | Residue | Details |
| A | ALA36-GLY46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; specific for D-alanine => ECO:0000305|PubMed:22194336 |
| Chain | Residue | Details |
| A | LYS39 | |
| B | LYS39 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; specific for L-alanine => ECO:0000305|PubMed:22194336 |
| Chain | Residue | Details |
| A | TYR265 | |
| B | TYR265 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01201 |
| Chain | Residue | Details |
| A | ARG138 | |
| B | ARG138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | MET312 | |
| B | MET312 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS39 | |
| B | LYS39 |
