4A2Y
STRUCTURE OF THE HUMAN EOSINOPHIL CATIONIC PROTEIN IN COMPLEX WITH CITRATE ANIONS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0002227 | biological_process | innate immune response in mucosa |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006935 | biological_process | chemotaxis |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0043152 | biological_process | induction of bacterial agglutination |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CIT A 301 |
| Chain | Residue |
| A | THR46 |
| A | HOH2121 |
| A | HOH2126 |
| A | HOH2129 |
| A | HOH2222 |
| A | HOH2223 |
| B | ARG121 |
| A | ASN50 |
| A | SER74 |
| A | ARG75 |
| A | ARG75 |
| A | PHE76 |
| A | VAL78 |
| A | TYR107 |
| A | HOH2119 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT A 302 |
| Chain | Residue |
| A | ARG34 |
| A | ARG34 |
| A | LYS38 |
| A | ASN39 |
| A | ASN39 |
| A | HOH2092 |
| A | HOH2092 |
| A | HOH2224 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CIT B 301 |
| Chain | Residue |
| A | ARG61 |
| A | ARG66 |
| A | HOH2149 |
| B | THR46 |
| B | ASN50 |
| B | VAL54 |
| B | ASN57 |
| B | SER74 |
| B | ARG75 |
| B | PHE76 |
| B | VAL78 |
| B | TYR107 |
| B | HOH2047 |
| B | HOH2048 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT B 302 |
| Chain | Residue |
| B | ARG34 |
| B | ARG34 |
| B | CYS37 |
| B | LYS38 |
| B | LYS38 |
| B | ASN39 |
| B | ASN39 |
| B | HOH2078 |
| B | HOH2079 |
| B | HOH2079 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT B 303 |
| Chain | Residue |
| A | ARG45 |
| A | HOH2057 |
| A | HOH2058 |
| A | HOH2059 |
| B | ARG114 |
| B | PRO116 |
| B | HOH2064 |
| B | HOH2065 |
| B | HOH2066 |
| B | HOH2082 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MPD A 1134 |
| Chain | Residue |
| A | ARG97 |
| A | HOH2065 |
| A | HOH2066 |
| A | HOH2188 |
| A | HOH2189 |
| A | HOH2226 |
| A | HOH2227 |
| A | HOH2228 |
| A | HOH2228 |
| B | ARG77 |
| B | ARG77 |
| B | HOH2050 |
| B | HOH2051 |
| B | HOH2051 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS15 | |
| B | HIS15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS128 | |
| B | HIS128 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS38 | |
| B | LYS38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS-binding |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS- and LTA-binding |
| Chain | Residue | Details |
| A | TRP35 | |
| B | TRP35 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936 |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN57 | |
| A | ASN65 | |
| A | ASN92 | |
| B | ASN57 | |
| B | ASN65 | |
| B | ASN92 |
