4A0O

Symmetry-free cryo-EM map of TRiC in the nucleotide-free (apo) state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002199	cellular_component	zona pellucida receptor complex
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005832	cellular_component	chaperonin-containing T-complex
A	0005874	cellular_component	microtubule
A	0006457	biological_process	protein folding
A	0007339	biological_process	binding of sperm to zona pellucida
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0044183	molecular_function	protein folding chaperone
A	0044297	cellular_component	cell body
A	0046872	molecular_function	metal ion binding
A	0050821	biological_process	protein stabilization
A	0051082	molecular_function	unfolded protein binding
A	0051131	biological_process	chaperone-mediated protein complex assembly
A	0061077	biological_process	obsolete chaperone-mediated protein folding
A	0090666	biological_process	scaRNA localization to Cajal body
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
B	0000166	molecular_function	nucleotide binding
B	0002199	cellular_component	zona pellucida receptor complex
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005832	cellular_component	chaperonin-containing T-complex
B	0005874	cellular_component	microtubule
B	0006457	biological_process	protein folding
B	0007339	biological_process	binding of sperm to zona pellucida
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0044183	molecular_function	protein folding chaperone
B	0044297	cellular_component	cell body
B	0046872	molecular_function	metal ion binding
B	0050821	biological_process	protein stabilization
B	0051082	molecular_function	unfolded protein binding
B	0051131	biological_process	chaperone-mediated protein complex assembly
B	0061077	biological_process	obsolete chaperone-mediated protein folding
B	0090666	biological_process	scaRNA localization to Cajal body
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
C	0000166	molecular_function	nucleotide binding
C	0002199	cellular_component	zona pellucida receptor complex
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005832	cellular_component	chaperonin-containing T-complex
C	0005874	cellular_component	microtubule
C	0006457	biological_process	protein folding
C	0007339	biological_process	binding of sperm to zona pellucida
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0044183	molecular_function	protein folding chaperone
C	0044297	cellular_component	cell body
C	0046872	molecular_function	metal ion binding
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
C	0051131	biological_process	chaperone-mediated protein complex assembly
C	0061077	biological_process	obsolete chaperone-mediated protein folding
C	0090666	biological_process	scaRNA localization to Cajal body
C	0140662	molecular_function	ATP-dependent protein folding chaperone
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
D	0000166	molecular_function	nucleotide binding
D	0002199	cellular_component	zona pellucida receptor complex
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005832	cellular_component	chaperonin-containing T-complex
D	0005874	cellular_component	microtubule
D	0006457	biological_process	protein folding
D	0007339	biological_process	binding of sperm to zona pellucida
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032212	biological_process	positive regulation of telomere maintenance via telomerase
D	0044183	molecular_function	protein folding chaperone
D	0044297	cellular_component	cell body
D	0046872	molecular_function	metal ion binding
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
D	0051131	biological_process	chaperone-mediated protein complex assembly
D	0061077	biological_process	obsolete chaperone-mediated protein folding
D	0090666	biological_process	scaRNA localization to Cajal body
D	0140662	molecular_function	ATP-dependent protein folding chaperone
D	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
E	0000166	molecular_function	nucleotide binding
E	0002199	cellular_component	zona pellucida receptor complex
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005832	cellular_component	chaperonin-containing T-complex
E	0005874	cellular_component	microtubule
E	0006457	biological_process	protein folding
E	0007339	biological_process	binding of sperm to zona pellucida
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032212	biological_process	positive regulation of telomere maintenance via telomerase
E	0044183	molecular_function	protein folding chaperone
E	0044297	cellular_component	cell body
E	0046872	molecular_function	metal ion binding
E	0050821	biological_process	protein stabilization
E	0051082	molecular_function	unfolded protein binding
E	0051131	biological_process	chaperone-mediated protein complex assembly
E	0061077	biological_process	obsolete chaperone-mediated protein folding
E	0090666	biological_process	scaRNA localization to Cajal body
E	0140662	molecular_function	ATP-dependent protein folding chaperone
E	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
F	0000166	molecular_function	nucleotide binding
F	0002199	cellular_component	zona pellucida receptor complex
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005832	cellular_component	chaperonin-containing T-complex
F	0005874	cellular_component	microtubule
F	0006457	biological_process	protein folding
F	0007339	biological_process	binding of sperm to zona pellucida
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032212	biological_process	positive regulation of telomere maintenance via telomerase
F	0044183	molecular_function	protein folding chaperone
F	0044297	cellular_component	cell body
F	0046872	molecular_function	metal ion binding
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
F	0051131	biological_process	chaperone-mediated protein complex assembly
F	0061077	biological_process	obsolete chaperone-mediated protein folding
F	0090666	biological_process	scaRNA localization to Cajal body
F	0140662	molecular_function	ATP-dependent protein folding chaperone
F	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
G	0000166	molecular_function	nucleotide binding
G	0002199	cellular_component	zona pellucida receptor complex
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005832	cellular_component	chaperonin-containing T-complex
G	0005874	cellular_component	microtubule
G	0006457	biological_process	protein folding
G	0007339	biological_process	binding of sperm to zona pellucida
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032212	biological_process	positive regulation of telomere maintenance via telomerase
G	0044183	molecular_function	protein folding chaperone
G	0044297	cellular_component	cell body
G	0046872	molecular_function	metal ion binding
G	0050821	biological_process	protein stabilization
G	0051082	molecular_function	unfolded protein binding
G	0051131	biological_process	chaperone-mediated protein complex assembly
G	0061077	biological_process	obsolete chaperone-mediated protein folding
G	0090666	biological_process	scaRNA localization to Cajal body
G	0140662	molecular_function	ATP-dependent protein folding chaperone
G	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
H	0000166	molecular_function	nucleotide binding
H	0002199	cellular_component	zona pellucida receptor complex
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005832	cellular_component	chaperonin-containing T-complex
H	0005874	cellular_component	microtubule
H	0006457	biological_process	protein folding
H	0007339	biological_process	binding of sperm to zona pellucida
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032212	biological_process	positive regulation of telomere maintenance via telomerase
H	0044183	molecular_function	protein folding chaperone
H	0044297	cellular_component	cell body
H	0046872	molecular_function	metal ion binding
H	0050821	biological_process	protein stabilization
H	0051082	molecular_function	unfolded protein binding
H	0051131	biological_process	chaperone-mediated protein complex assembly
H	0061077	biological_process	obsolete chaperone-mediated protein folding
H	0090666	biological_process	scaRNA localization to Cajal body
H	0140662	molecular_function	ATP-dependent protein folding chaperone
H	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
I	0000166	molecular_function	nucleotide binding
I	0002199	cellular_component	zona pellucida receptor complex
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005832	cellular_component	chaperonin-containing T-complex
I	0005874	cellular_component	microtubule
I	0006457	biological_process	protein folding
I	0007339	biological_process	binding of sperm to zona pellucida
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032212	biological_process	positive regulation of telomere maintenance via telomerase
I	0044183	molecular_function	protein folding chaperone
I	0044297	cellular_component	cell body
I	0046872	molecular_function	metal ion binding
I	0050821	biological_process	protein stabilization
I	0051082	molecular_function	unfolded protein binding
I	0051131	biological_process	chaperone-mediated protein complex assembly
I	0061077	biological_process	obsolete chaperone-mediated protein folding
I	0090666	biological_process	scaRNA localization to Cajal body
I	0140662	molecular_function	ATP-dependent protein folding chaperone
I	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
J	0000166	molecular_function	nucleotide binding
J	0002199	cellular_component	zona pellucida receptor complex
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005832	cellular_component	chaperonin-containing T-complex
J	0005874	cellular_component	microtubule
J	0006457	biological_process	protein folding
J	0007339	biological_process	binding of sperm to zona pellucida
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032212	biological_process	positive regulation of telomere maintenance via telomerase
J	0044183	molecular_function	protein folding chaperone
J	0044297	cellular_component	cell body
J	0046872	molecular_function	metal ion binding
J	0050821	biological_process	protein stabilization
J	0051082	molecular_function	unfolded protein binding
J	0051131	biological_process	chaperone-mediated protein complex assembly
J	0061077	biological_process	obsolete chaperone-mediated protein folding
J	0090666	biological_process	scaRNA localization to Cajal body
J	0140662	molecular_function	ATP-dependent protein folding chaperone
J	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
K	0000166	molecular_function	nucleotide binding
K	0002199	cellular_component	zona pellucida receptor complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005832	cellular_component	chaperonin-containing T-complex
K	0005874	cellular_component	microtubule
K	0006457	biological_process	protein folding
K	0007339	biological_process	binding of sperm to zona pellucida
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032212	biological_process	positive regulation of telomere maintenance via telomerase
K	0044183	molecular_function	protein folding chaperone
K	0044297	cellular_component	cell body
K	0046872	molecular_function	metal ion binding
K	0050821	biological_process	protein stabilization
K	0051082	molecular_function	unfolded protein binding
K	0051131	biological_process	chaperone-mediated protein complex assembly
K	0061077	biological_process	obsolete chaperone-mediated protein folding
K	0090666	biological_process	scaRNA localization to Cajal body
K	0140662	molecular_function	ATP-dependent protein folding chaperone
K	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
L	0000166	molecular_function	nucleotide binding
L	0002199	cellular_component	zona pellucida receptor complex
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005832	cellular_component	chaperonin-containing T-complex
L	0005874	cellular_component	microtubule
L	0006457	biological_process	protein folding
L	0007339	biological_process	binding of sperm to zona pellucida
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032212	biological_process	positive regulation of telomere maintenance via telomerase
L	0044183	molecular_function	protein folding chaperone
L	0044297	cellular_component	cell body
L	0046872	molecular_function	metal ion binding
L	0050821	biological_process	protein stabilization
L	0051082	molecular_function	unfolded protein binding
L	0051131	biological_process	chaperone-mediated protein complex assembly
L	0061077	biological_process	obsolete chaperone-mediated protein folding
L	0090666	biological_process	scaRNA localization to Cajal body
L	0140662	molecular_function	ATP-dependent protein folding chaperone
L	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
M	0000166	molecular_function	nucleotide binding
M	0002199	cellular_component	zona pellucida receptor complex
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005832	cellular_component	chaperonin-containing T-complex
M	0005874	cellular_component	microtubule
M	0006457	biological_process	protein folding
M	0007339	biological_process	binding of sperm to zona pellucida
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032212	biological_process	positive regulation of telomere maintenance via telomerase
M	0044183	molecular_function	protein folding chaperone
M	0044297	cellular_component	cell body
M	0046872	molecular_function	metal ion binding
M	0050821	biological_process	protein stabilization
M	0051082	molecular_function	unfolded protein binding
M	0051131	biological_process	chaperone-mediated protein complex assembly
M	0061077	biological_process	obsolete chaperone-mediated protein folding
M	0090666	biological_process	scaRNA localization to Cajal body
M	0140662	molecular_function	ATP-dependent protein folding chaperone
M	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
N	0000166	molecular_function	nucleotide binding
N	0002199	cellular_component	zona pellucida receptor complex
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005832	cellular_component	chaperonin-containing T-complex
N	0005874	cellular_component	microtubule
N	0006457	biological_process	protein folding
N	0007339	biological_process	binding of sperm to zona pellucida
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0032212	biological_process	positive regulation of telomere maintenance via telomerase
N	0044183	molecular_function	protein folding chaperone
N	0044297	cellular_component	cell body
N	0046872	molecular_function	metal ion binding
N	0050821	biological_process	protein stabilization
N	0051082	molecular_function	unfolded protein binding
N	0051131	biological_process	chaperone-mediated protein complex assembly
N	0061077	biological_process	obsolete chaperone-mediated protein folding
N	0090666	biological_process	scaRNA localization to Cajal body
N	0140662	molecular_function	ATP-dependent protein folding chaperone
N	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
O	0000166	molecular_function	nucleotide binding
O	0002199	cellular_component	zona pellucida receptor complex
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005832	cellular_component	chaperonin-containing T-complex
O	0005874	cellular_component	microtubule
O	0006457	biological_process	protein folding
O	0007339	biological_process	binding of sperm to zona pellucida
O	0016787	molecular_function	hydrolase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0032212	biological_process	positive regulation of telomere maintenance via telomerase
O	0044183	molecular_function	protein folding chaperone
O	0044297	cellular_component	cell body
O	0046872	molecular_function	metal ion binding
O	0050821	biological_process	protein stabilization
O	0051082	molecular_function	unfolded protein binding
O	0051131	biological_process	chaperone-mediated protein complex assembly
O	0061077	biological_process	obsolete chaperone-mediated protein folding
O	0090666	biological_process	scaRNA localization to Cajal body
O	0140662	molecular_function	ATP-dependent protein folding chaperone
O	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
P	0000166	molecular_function	nucleotide binding
P	0002199	cellular_component	zona pellucida receptor complex
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005832	cellular_component	chaperonin-containing T-complex
P	0005874	cellular_component	microtubule
P	0006457	biological_process	protein folding
P	0007339	biological_process	binding of sperm to zona pellucida
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0032212	biological_process	positive regulation of telomere maintenance via telomerase
P	0044183	molecular_function	protein folding chaperone
P	0044297	cellular_component	cell body
P	0046872	molecular_function	metal ion binding
P	0050821	biological_process	protein stabilization
P	0051082	molecular_function	unfolded protein binding
P	0051131	biological_process	chaperone-mediated protein complex assembly
P	0061077	biological_process	obsolete chaperone-mediated protein folding
P	0090666	biological_process	scaRNA localization to Cajal body
P	0140662	molecular_function	ATP-dependent protein folding chaperone
P	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGDGTTSVTVlAaellreaesl........IAKK

Chain	Residue	Details
A	VAL82-LYS107

---

site_id	PS00750
Number of Residues	13
Details	TCP1_1 Chaperonins TCP-1 signature 1. KStLGPkGmdKIL

Chain	Residue	Details
A	LYS27-LEU39

---

site_id	PS00751
Number of Residues	17
Details	TCP1_2 Chaperonins TCP-1 signature 2. VTNDGATILknIgVdNP

Chain	Residue	Details
A	VAL50-PRO66

---

site_id	PS00995
Number of Residues	9
Details	TCP1_3 Chaperonins TCP-1 signature 3. QDdeVGDGT

Chain	Residue	Details
A	GLN78-THR86

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P78371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P78371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P78371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P78371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P78371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---