45CQ

F306, a fluorinated amino acid-containing CI2 variant, bound to alpha-chymotrypsin

This is a non-PDB format compatible entry.

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
A	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV

Chain	Residue	Details
D	SER189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 387

Chain	Residue	Details
C	ARG65	electrostatic stabiliser
C	ARG67	covalent catalysis
C	A1MJG68	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	3
Details	M-CSA 387

Chain	Residue	Details
F	SER189	electrostatic stabiliser, proton shuttle (general acid/base)
F	LEU234	modifies pKa

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