43CA

CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0016064	biological_process	immunoglobulin mediated immune response
B	0019814	cellular_component	immunoglobulin complex
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0016064	biological_process	immunoglobulin mediated immune response
D	0019814	cellular_component	immunoglobulin complex
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0003823	molecular_function	antigen binding
F	0005576	cellular_component	extracellular region
F	0016064	biological_process	immunoglobulin mediated immune response
F	0019814	cellular_component	immunoglobulin complex
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0016064	biological_process	immunoglobulin mediated immune response
H	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	CATALYTIC SITE IS BELIEVED TO INCLUDE: HIS 91 IN THE VARIABLE LIGHT CHAIN - NUCLEOPHILE THAT FORMS A COVALENT BOND TO THE SUBSTRATE ARG 96 IN THE VARIABLE LIGHT CHAIN - SIDE CHAIN STABILIZES NEGATIVE CHARGE FORMED IN THE TRANSITION STATES OF THE REACTION

Chain	Residue
A	HIS91
A	ARG96

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site_id	AC2
Number of Residues	2
Details	CATALYTIC SITE IS BELIEVED TO INCLUDE: HIS 91 IN THE VARIABLE LIGHT CHAIN - NUCLEOPHILE THAT FORMS A COVALENT BOND TO THE SUBSTRATE ARG 96 IN THE VARIABLE LIGHT CHAIN - SIDE CHAIN STABILIZES NEGATIVE CHARGE FORMED IN THE TRANSITION STATES OF THE REACTION

Chain	Residue
C	HIS91
C	ARG96

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site_id	AC3
Number of Residues	2
Details	CATALYTIC SITE IS BELIEVED TO INCLUDE: HIS 91 IN THE VARIABLE LIGHT CHAIN - NUCLEOPHILE THAT FORMS A COVALENT BOND TO THE SUBSTRATE ARG 96 IN THE VARIABLE LIGHT CHAIN - SIDE CHAIN STABILIZES NEGATIVE CHARGE FORMED IN THE TRANSITION STATES OF THE REACTION

Chain	Residue
E	HIS91
E	ARG96

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site_id	AC4
Number of Residues	2
Details	CATALYTIC SITE IS BELIEVED TO INCLUDE: HIS 91 IN THE VARIABLE LIGHT CHAIN - NUCLEOPHILE THAT FORMS A COVALENT BOND TO THE SUBSTRATE ARG 96 IN THE VARIABLE LIGHT CHAIN - SIDE CHAIN STABILIZES NEGATIVE CHARGE FORMED IN THE TRANSITION STATES OF THE REACTION

Chain	Residue
G	HIS91
G	ARG96

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site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NPO A 921

Chain	Residue
A	TYR32
A	LEU33
A	ALA34
A	TYR49
A	PHE50
A	HIS91
B	TYR95
B	PHE100
B	HOH132
A	ASN31

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site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NPO C 922

Chain	Residue
C	ASN31
C	TYR32
C	LEU33
C	ALA34
C	TYR49
C	PHE50
C	HIS91
D	PHE100
D	HOH135

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site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NPO E 923

Chain	Residue
E	TYR32
E	LEU33
E	ALA34
E	TYR49
E	PHE50
E	HOH924
F	TYR95
F	PHE100

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site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NPO G 924

Chain	Residue
G	TYR32
G	LEU33
G	ALA34
G	TYR49
G	PHE50
G	HIS91
G	HOH588
H	TYR95

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