3ZZM
Crystal structure of Mycobacterium tuberculosis PurH with a novel bound nucleotide CFAIR, at 2.2 A resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003937 | molecular_function | IMP cyclohydrolase activity |
| A | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003937 | molecular_function | IMP cyclohydrolase activity |
| B | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1524 |
| Chain | Residue |
| A | TYR225 |
| A | ASN259 |
| A | HOH2091 |
| A | HOH2162 |
| B | ARG519 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1525 |
| Chain | Residue |
| A | HIS520 |
| A | ALA522 |
| A | CYS421 |
| A | ARG422 |
| A | VAL424 |
| A | ASP470 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 1524 |
| Chain | Residue |
| B | CYS421 |
| B | ARG422 |
| B | VAL424 |
| B | ASP470 |
| B | HIS520 |
| B | ALA522 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1525 |
| Chain | Residue |
| A | ILE132 |
| A | PRO135 |
| A | ALA136 |
| A | ARG139 |
| B | ILE132 |
| B | PRO135 |
| B | ALA136 |
| B | ARG139 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE JLN A 1526 |
| Chain | Residue |
| A | SER16 |
| A | VAL17 |
| A | TYR18 |
| A | LYS20 |
| A | THR40 |
| A | GLY41 |
| A | SER42 |
| A | THR43 |
| A | GLY69 |
| A | ARG70 |
| A | VAL71 |
| A | LYS72 |
| A | THR73 |
| A | LEU74 |
| A | ASN109 |
| A | TYR111 |
| A | ASP131 |
| A | ILE132 |
| A | GLY133 |
| A | GLY134 |
| A | MET137 |
| A | HOH2017 |
