3ZWX
Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003953 | molecular_function | NAD+ nucleosidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0007338 | biological_process | single fertilization |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
A | 0030890 | biological_process | positive regulation of B cell proliferation |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
B | 0003953 | molecular_function | NAD+ nucleosidase activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0007338 | biological_process | single fertilization |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
B | 0030890 | biological_process | positive regulation of B cell proliferation |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
C | 0003953 | molecular_function | NAD+ nucleosidase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0007338 | biological_process | single fertilization |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
C | 0030890 | biological_process | positive regulation of B cell proliferation |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
D | 0003953 | molecular_function | NAD+ nucleosidase activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0007338 | biological_process | single fertilization |
D | 0016020 | cellular_component | membrane |
D | 0016740 | molecular_function | transferase activity |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
D | 0030890 | biological_process | positive regulation of B cell proliferation |
D | 0031410 | cellular_component | cytoplasmic vesicle |
D | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
E | 0003953 | molecular_function | NAD+ nucleosidase activity |
E | 0005886 | cellular_component | plasma membrane |
E | 0007338 | biological_process | single fertilization |
E | 0016020 | cellular_component | membrane |
E | 0016740 | molecular_function | transferase activity |
E | 0016787 | molecular_function | hydrolase activity |
E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
E | 0030890 | biological_process | positive regulation of B cell proliferation |
E | 0031410 | cellular_component | cytoplasmic vesicle |
E | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
F | 0003953 | molecular_function | NAD+ nucleosidase activity |
F | 0005886 | cellular_component | plasma membrane |
F | 0007338 | biological_process | single fertilization |
F | 0016020 | cellular_component | membrane |
F | 0016740 | molecular_function | transferase activity |
F | 0016787 | molecular_function | hydrolase activity |
F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
F | 0030890 | biological_process | positive regulation of B cell proliferation |
F | 0031410 | cellular_component | cytoplasmic vesicle |
F | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
G | 0003953 | molecular_function | NAD+ nucleosidase activity |
G | 0005886 | cellular_component | plasma membrane |
G | 0007338 | biological_process | single fertilization |
G | 0016020 | cellular_component | membrane |
G | 0016740 | molecular_function | transferase activity |
G | 0016787 | molecular_function | hydrolase activity |
G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
G | 0030890 | biological_process | positive regulation of B cell proliferation |
G | 0031410 | cellular_component | cytoplasmic vesicle |
G | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
H | 0003953 | molecular_function | NAD+ nucleosidase activity |
H | 0005886 | cellular_component | plasma membrane |
H | 0007338 | biological_process | single fertilization |
H | 0016020 | cellular_component | membrane |
H | 0016740 | molecular_function | transferase activity |
H | 0016787 | molecular_function | hydrolase activity |
H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
H | 0030890 | biological_process | positive regulation of B cell proliferation |
H | 0031410 | cellular_component | cytoplasmic vesicle |
H | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AV1 A 1682 |
Chain | Residue |
A | PHE76 |
A | PHE174 |
A | PHE175 |
A | GLU179 |
A | HOH2047 |
A | TRP77 |
A | SER78 |
A | GLY79 |
A | TYR81 |
A | ASN107 |
A | SER108 |
A | SER144 |
A | SER173 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AV1 B 1682 |
Chain | Residue |
B | TRP77 |
B | SER78 |
B | GLY79 |
B | LEU97 |
B | ASN107 |
B | SER108 |
B | SER144 |
B | SER173 |
B | PHE174 |
B | PHE175 |
B | GLU179 |
B | HOH2047 |
B | HOH2048 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AV1 C 1682 |
Chain | Residue |
C | PHE76 |
C | TRP77 |
C | SER78 |
C | GLY79 |
C | LEU97 |
C | GLU98 |
C | ASN107 |
C | SER108 |
C | PHE174 |
C | PHE175 |
C | GLU179 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AV1 D 1682 |
Chain | Residue |
D | PHE76 |
D | TRP77 |
D | SER78 |
D | GLY79 |
D | TYR81 |
D | ASN107 |
D | SER108 |
D | SER144 |
D | ARG170 |
D | SER173 |
D | PHE174 |
D | PHE175 |
D | GLU179 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AV1 E 1682 |
Chain | Residue |
E | PHE76 |
E | TRP77 |
E | SER78 |
E | GLY79 |
E | LEU97 |
E | ASN107 |
E | SER108 |
E | SER144 |
E | ARG170 |
E | SER173 |
E | PHE174 |
E | PHE175 |
E | GLU179 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AV1 F 1682 |
Chain | Residue |
F | PHE76 |
F | TRP77 |
F | SER78 |
F | GLY79 |
F | TYR81 |
F | ASN107 |
F | SER144 |
F | ARG170 |
F | PHE174 |
F | PHE175 |
F | GLU179 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AV1 G 1682 |
Chain | Residue |
G | PHE76 |
G | TRP77 |
G | SER78 |
G | GLY79 |
G | TYR81 |
G | ASN107 |
G | SER144 |
G | ARG170 |
G | SER173 |
G | PHE174 |
G | PHE175 |
G | GLU179 |
G | HOH2038 |
site_id | AC8 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE AV1 H 1682 |
Chain | Residue |
H | PHE175 |
H | GLU179 |
F | LYS252 |
H | PHE76 |
H | TRP77 |
H | SER78 |
H | GLY79 |
H | TYR81 |
H | LEU97 |
H | ASN107 |
H | SER144 |
H | ARG170 |
H | SER173 |
H | PHE174 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 1251 |
Chain | Residue |
A | ASN242 |
A | PRO243 |
A | ASN244 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 1253 |
Chain | Residue |
C | ASN242 |
C | PRO243 |
C | ASN244 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL F 1253 |
Chain | Residue |
F | ASN242 |
F | PRO243 |
F | ASN244 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 1252 |
Chain | Residue |
G | ASN242 |
G | PRO243 |
G | ASN244 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
A | GLU98 | electrostatic stabiliser |
A | PHE174 | hydrophobic interaction |
A | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
B | GLU98 | electrostatic stabiliser |
B | PHE174 | hydrophobic interaction |
B | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
C | GLU98 | electrostatic stabiliser |
C | PHE174 | hydrophobic interaction |
C | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
D | GLU98 | electrostatic stabiliser |
D | PHE174 | hydrophobic interaction |
D | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA5 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
E | GLU98 | electrostatic stabiliser |
E | PHE174 | hydrophobic interaction |
E | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA6 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
F | GLU98 | electrostatic stabiliser |
F | PHE174 | hydrophobic interaction |
F | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA7 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
G | GLU98 | electrostatic stabiliser |
G | PHE174 | hydrophobic interaction |
G | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA8 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
H | GLU98 | electrostatic stabiliser |
H | PHE174 | hydrophobic interaction |
H | GLU179 | covalent catalysis, covalently attached, nucleophile |