3ZWP
Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1 angstrom
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003953 | molecular_function | NAD+ nucleosidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0007338 | biological_process | single fertilization |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
A | 0030890 | biological_process | positive regulation of B cell proliferation |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
B | 0003953 | molecular_function | NAD+ nucleosidase activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0007338 | biological_process | single fertilization |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
B | 0030890 | biological_process | positive regulation of B cell proliferation |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
C | 0003953 | molecular_function | NAD+ nucleosidase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0007338 | biological_process | single fertilization |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
C | 0030890 | biological_process | positive regulation of B cell proliferation |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
D | 0003953 | molecular_function | NAD+ nucleosidase activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0007338 | biological_process | single fertilization |
D | 0016020 | cellular_component | membrane |
D | 0016740 | molecular_function | transferase activity |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
D | 0030890 | biological_process | positive regulation of B cell proliferation |
D | 0031410 | cellular_component | cytoplasmic vesicle |
D | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
E | 0003953 | molecular_function | NAD+ nucleosidase activity |
E | 0005886 | cellular_component | plasma membrane |
E | 0007338 | biological_process | single fertilization |
E | 0016020 | cellular_component | membrane |
E | 0016740 | molecular_function | transferase activity |
E | 0016787 | molecular_function | hydrolase activity |
E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
E | 0030890 | biological_process | positive regulation of B cell proliferation |
E | 0031410 | cellular_component | cytoplasmic vesicle |
E | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
F | 0003953 | molecular_function | NAD+ nucleosidase activity |
F | 0005886 | cellular_component | plasma membrane |
F | 0007338 | biological_process | single fertilization |
F | 0016020 | cellular_component | membrane |
F | 0016740 | molecular_function | transferase activity |
F | 0016787 | molecular_function | hydrolase activity |
F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
F | 0030890 | biological_process | positive regulation of B cell proliferation |
F | 0031410 | cellular_component | cytoplasmic vesicle |
F | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
G | 0003953 | molecular_function | NAD+ nucleosidase activity |
G | 0005886 | cellular_component | plasma membrane |
G | 0007338 | biological_process | single fertilization |
G | 0016020 | cellular_component | membrane |
G | 0016740 | molecular_function | transferase activity |
G | 0016787 | molecular_function | hydrolase activity |
G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
G | 0030890 | biological_process | positive regulation of B cell proliferation |
G | 0031410 | cellular_component | cytoplasmic vesicle |
G | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
H | 0003953 | molecular_function | NAD+ nucleosidase activity |
H | 0005886 | cellular_component | plasma membrane |
H | 0007338 | biological_process | single fertilization |
H | 0016020 | cellular_component | membrane |
H | 0016740 | molecular_function | transferase activity |
H | 0016787 | molecular_function | hydrolase activity |
H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
H | 0030890 | biological_process | positive regulation of B cell proliferation |
H | 0031410 | cellular_component | cytoplasmic vesicle |
H | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE AVU A 301 |
Chain | Residue |
A | PHE76 |
A | SER173 |
A | PHE174 |
A | PHE175 |
A | GLU179 |
A | HOH2076 |
A | HOH2116 |
A | TRP77 |
A | SER78 |
A | GLY79 |
A | GLU98 |
A | ASN107 |
A | TRP140 |
A | SER144 |
A | ARG170 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AVU B 301 |
Chain | Residue |
B | PHE76 |
B | TRP77 |
B | SER78 |
B | GLY79 |
B | TYR81 |
B | LEU97 |
B | ASN107 |
B | SER144 |
B | ARG170 |
B | PHE174 |
B | PHE175 |
B | GLU179 |
B | HOH2115 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE AVU C 301 |
Chain | Residue |
C | PHE76 |
C | TRP77 |
C | SER78 |
C | GLY79 |
C | LEU97 |
C | GLU98 |
C | ASN107 |
C | TRP140 |
C | SER144 |
C | ARG170 |
C | SER173 |
C | PHE174 |
C | PHE175 |
C | GLU179 |
C | HOH2096 |
C | HOH2121 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE AVU D 301 |
Chain | Residue |
D | PHE76 |
D | TRP77 |
D | SER78 |
D | GLY79 |
D | TYR81 |
D | LEU97 |
D | GLU98 |
D | ASN107 |
D | TRP140 |
D | SER144 |
D | ARG170 |
D | SER173 |
D | PHE174 |
D | PHE175 |
D | GLU179 |
D | HOH2145 |
D | HOH2172 |
D | HOH2173 |
D | HOH2174 |
D | HOH2175 |
D | HOH2176 |
site_id | AC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE AVU E 301 |
Chain | Residue |
E | PHE76 |
E | TRP77 |
E | SER78 |
E | GLY79 |
E | TYR81 |
E | LEU97 |
E | ASN107 |
E | SER144 |
E | ARG170 |
E | SER173 |
E | PHE174 |
E | PHE175 |
E | GLU179 |
E | HOH2063 |
E | HOH2111 |
E | HOH2139 |
site_id | AC6 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE AVU F 301 |
Chain | Residue |
F | PHE76 |
F | TRP77 |
F | SER78 |
F | GLY79 |
F | LEU97 |
F | GLU98 |
F | ASN107 |
F | TRP140 |
F | SER144 |
F | ARG170 |
F | SER173 |
F | PHE174 |
F | PHE175 |
F | GLU179 |
F | HOH2040 |
F | HOH2053 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE AVU G 301 |
Chain | Residue |
G | SER78 |
G | GLY79 |
G | LEU97 |
G | GLU98 |
G | TRP140 |
G | SER144 |
G | ARG170 |
G | SER173 |
G | PHE174 |
G | PHE175 |
G | GLU179 |
G | HOH2067 |
G | HOH2112 |
G | PHE76 |
G | TRP77 |
site_id | AC8 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE AVU H 301 |
Chain | Residue |
H | PHE76 |
H | TRP77 |
H | SER78 |
H | GLY79 |
H | GLU98 |
H | ASN107 |
H | TRP140 |
H | SER144 |
H | ARG170 |
H | SER173 |
H | PHE174 |
H | PHE175 |
H | GLU179 |
H | HOH2033 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 1253 |
Chain | Residue |
C | ARG22 |
C | TYR23 |
C | THR90 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL D 1253 |
Chain | Residue |
D | ARG22 |
D | TYR23 |
D | ILE26 |
D | HOH2029 |
D | HOH2100 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL F 1253 |
Chain | Residue |
F | TYR81 |
F | HOH2028 |
G | ARG249 |
H | ALA251 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
A | GLU98 | electrostatic stabiliser |
A | PHE174 | hydrophobic interaction |
A | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
B | GLU98 | electrostatic stabiliser |
B | PHE174 | hydrophobic interaction |
B | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
C | GLU98 | electrostatic stabiliser |
C | PHE174 | hydrophobic interaction |
C | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
D | GLU98 | electrostatic stabiliser |
D | PHE174 | hydrophobic interaction |
D | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA5 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
E | GLU98 | electrostatic stabiliser |
E | PHE174 | hydrophobic interaction |
E | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA6 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
F | GLU98 | electrostatic stabiliser |
F | PHE174 | hydrophobic interaction |
F | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA7 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
G | GLU98 | electrostatic stabiliser |
G | PHE174 | hydrophobic interaction |
G | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA8 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
H | GLU98 | electrostatic stabiliser |
H | PHE174 | hydrophobic interaction |
H | GLU179 | covalent catalysis, covalently attached, nucleophile |