3ZWH
Ca2+-bound S100A4 C3S, C81S, C86S and F45W mutant complexed with myosin IIA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001837 | biological_process | epithelial to mesenchymal transition |
A | 0003723 | molecular_function | RNA binding |
A | 0003779 | molecular_function | actin binding |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0042056 | molecular_function | chemoattractant activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
A | 0046872 | molecular_function | metal ion binding |
A | 0046914 | molecular_function | transition metal ion binding |
A | 0048306 | molecular_function | calcium-dependent protein binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0050786 | molecular_function | RAGE receptor binding |
A | 0050918 | biological_process | positive chemotaxis |
A | 0062023 | cellular_component | collagen-containing extracellular matrix |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001837 | biological_process | epithelial to mesenchymal transition |
B | 0003723 | molecular_function | RNA binding |
B | 0003779 | molecular_function | actin binding |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0042056 | molecular_function | chemoattractant activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
B | 0046872 | molecular_function | metal ion binding |
B | 0046914 | molecular_function | transition metal ion binding |
B | 0048306 | molecular_function | calcium-dependent protein binding |
B | 0048471 | cellular_component | perinuclear region of cytoplasm |
B | 0050786 | molecular_function | RAGE receptor binding |
B | 0050918 | biological_process | positive chemotaxis |
B | 0062023 | cellular_component | collagen-containing extracellular matrix |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 501 |
Chain | Residue |
A | SER20 |
A | GLU23 |
A | ASP25 |
A | LYS28 |
A | GLU33 |
A | HOH2038 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 502 |
Chain | Residue |
A | GLU69 |
A | GLU74 |
A | HOH2087 |
A | ASP63 |
A | ASN65 |
A | ASP67 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 501 |
Chain | Residue |
B | SER20 |
B | GLU23 |
B | ASP25 |
B | LYS28 |
B | GLU33 |
B | HOH2022 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 502 |
Chain | Residue |
B | ASP63 |
B | ASN65 |
B | ASP67 |
B | GLU69 |
B | GLU74 |
B | HOH2028 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT A 1095 |
Chain | Residue |
A | LEU46 |
A | ACT1096 |
A | HOH2058 |
A | HOH2072 |
A | HOH2073 |
Q | ARG1912 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT A 1096 |
Chain | Residue |
A | LEU46 |
A | GLY47 |
A | ACT1095 |
A | HOH2100 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE AZI B 1100 |
Chain | Residue |
B | PRO4 |
B | HOH2002 |
B | HOH2012 |
B | HOH2069 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE AZI Q 2936 |
Chain | Residue |
Q | LYS1920 |
Q | LEU1921 |
Q | GLY1924 |
Q | ASP1925 |
Q | LEU1926 |
Q | VAL1929 |
Q | PRO1931 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q61879 |
Chain | Residue | Details |
Q | ARG1923 | |
A | GLU33 | |
B | LYS28 | |
B | GLU33 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
Chain | Residue | Details |
A | ASP63 | |
B | GLU74 | |
A | ASN65 | |
A | ASP67 | |
A | GLU69 | |
A | GLU74 | |
B | ASP63 | |
B | ASN65 | |
B | ASP67 | |
B | GLU69 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P35466 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS7 | |
A | LYS35 | |
B | LYS7 | |
B | LYS35 |