3ZWF
Crystal structure of Human tRNase Z, short form (ELAC1).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004549 | molecular_function | tRNA-specific ribonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008033 | biological_process | tRNA processing |
| A | 0016891 | molecular_function | RNA endonuclease activity, producing 5'-phosphomonoesters |
| A | 0042780 | biological_process | tRNA 3'-end processing |
| A | 0042781 | molecular_function | 3'-tRNA processing endoribonuclease activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0072344 | biological_process | rescue of stalled ribosome |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004549 | molecular_function | tRNA-specific ribonuclease activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008033 | biological_process | tRNA processing |
| B | 0016891 | molecular_function | RNA endonuclease activity, producing 5'-phosphomonoesters |
| B | 0042780 | biological_process | tRNA 3'-end processing |
| B | 0042781 | molecular_function | 3'-tRNA processing endoribonuclease activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0072344 | biological_process | rescue of stalled ribosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1362 |
| Chain | Residue |
| A | ASP101 |
| A | EDO1368 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1363 |
| Chain | Residue |
| A | ASP66 |
| A | HIS67 |
| A | ASP253 |
| A | HIS313 |
| A | ZN1364 |
| A | PO41365 |
| A | HOH2056 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1364 |
| Chain | Residue |
| A | HIS62 |
| A | HIS64 |
| A | HIS182 |
| A | ASP253 |
| A | ZN1363 |
| A | PO41365 |
| A | HOH2056 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 1362 |
| Chain | Residue |
| B | HIS62 |
| B | HIS64 |
| B | HIS182 |
| B | ASP253 |
| B | ZN1363 |
| B | PO41364 |
| B | HOH2043 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 1363 |
| Chain | Residue |
| B | ASP66 |
| B | HIS67 |
| B | ASP253 |
| B | HIS313 |
| B | ZN1362 |
| B | PO41364 |
| B | HOH2043 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1364 |
| Chain | Residue |
| B | ALA13 |
| B | HIS64 |
| B | ASP66 |
| B | HIS182 |
| B | ARG183 |
| B | ASP253 |
| B | HIS291 |
| B | HIS313 |
| B | ZN1362 |
| B | ZN1363 |
| B | HOH2009 |
| B | HOH2043 |
| B | HOH2113 |
| B | HOH2124 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1365 |
| Chain | Residue |
| A | ALA13 |
| A | HIS64 |
| A | ASP66 |
| A | HIS182 |
| A | ARG183 |
| A | ASP253 |
| A | HIS291 |
| A | HIS313 |
| A | ZN1363 |
| A | ZN1364 |
| A | HOH2014 |
| A | HOH2056 |
| A | HOH2135 |
| A | HOH2155 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1366 |
| Chain | Residue |
| A | THR6 |
| A | GLN49 |
| A | LEU50 |
| A | VAL356 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1365 |
| Chain | Residue |
| B | LEU45 |
| B | MET46 |
| B | SER48 |
| B | LEU50 |
| B | HOH2034 |
| B | HOH2037 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1367 |
| Chain | Residue |
| A | MET3 |
| A | ASP4 |
| A | ARG27 |
| A | GLY30 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 1366 |
| Chain | Residue |
| B | PRO125 |
| B | HOH2125 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1367 |
| Chain | Residue |
| B | THR6 |
| B | ARG27 |
| B | LEU50 |
| B | VAL356 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1368 |
| Chain | Residue |
| A | TYR118 |
| A | EDO1362 |
| A | HOH2075 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1368 |
| Chain | Residue |
| A | HIS111 |
| A | HOH2085 |
| A | HOH2086 |
| B | CYS130 |
| B | ARG183 |
| B | PRO185 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1369 |
| Chain | Residue |
| B | SER22 |
| B | ASP36 |
| B | HIS67 |
| B | LEU251 |
| B | GLY252 |
| B | ASP253 |
| B | HIS313 |
| B | HOH2017 |
| B | HOH2126 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1369 |
| Chain | Residue |
| A | HOH2156 |
| B | GLY40 |
| B | THR43 |
| A | GLY40 |
| A | THR43 |
| A | EDO1370 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1370 |
| Chain | Residue |
| A | GLY40 |
| A | THR43 |
| A | GLN44 |
| A | EDO1369 |
| A | HOH2018 |
| A | HOH2028 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P54548 |
| Chain | Residue | Details |
| A | ASP66 | |
| B | ASP66 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|Ref.8, ECO:0007744|PDB:3ZWF |
| Chain | Residue | Details |
| A | HIS62 | |
| B | ASP66 | |
| B | HIS67 | |
| B | HIS182 | |
| B | ASP253 | |
| B | HIS313 | |
| A | HIS64 | |
| A | ASP66 | |
| A | HIS67 | |
| A | HIS182 | |
| A | ASP253 | |
| A | HIS313 | |
| B | HIS62 | |
| B | HIS64 |
