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3ZSZ

Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0015074biological_processDNA integration
B0003676molecular_functionnucleic acid binding
B0015074biological_processDNA integration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1210
ChainResidue
ATHR66
AHIS67
ALYS111
ALYS136
ALYS159
AHOH2036

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1211
ChainResidue
AHOH2038
ALYS71
AHIS171
ALEU172

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1212
ChainResidue
AGLY94
ASER123
ATHR124
ATHR125
AHOH2015
AHOH2031

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT A 1213
ChainResidue
ATYR99
ALYS103
AHOH2018
AHOH2051
BGLU87
BACT1213
BHOH2037

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 1214
ChainResidue
AGLU85
AGLU87
APHE100
ALYS103
ALEU104

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OM2 A 1215
ChainResidue
AASP167
AGLN168
AALA169
AGLU170
AHIS171
ALYS173
ATHR174
AMET178
BGLN95
BTYR99

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 1210
ChainResidue
BTHR66
BHIS67
BLYS111
BLYS136
BLYS159
BHOH2028

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1211
ChainResidue
BLYS71
BHIS171
BLEU172
BHOH2036

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1212
ChainResidue
BGLY94
BSER123
BTHR124
BTHR125
BHOH2013
BHOH2023
BHOH2044

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT B 1213
ChainResidue
AGLU87
AACT1213
AHOH2006
AHOH2008
AHOH2041
BTYR99
BLYS103

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 1214
ChainResidue
AALA105
AGLY106
AARG107
BASN184
BHIS185

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT B 1215
ChainResidue
AARG107
BGLU85
BGLU87
BPHE100
BLYS103
BLEU104

site_idBC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE OM2 B 1216
ChainResidue
AGLN95
ATYR99
BASP167
BGLN168
BALA169
BGLU170
BHIS171
BLYS173
BTHR174
BHOH2045

site_idBC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1217
ChainResidue
BMET178

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AASP64
AASP116
BASP64
BASP116

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04585
ChainResidueDetails
AGLU152
BGLU152

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PDB entries from 2024-07-10

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