3ZR4
STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA-ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009382 | cellular_component | imidazoleglycerol-phosphate synthase complex |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| D | 0004359 | molecular_function | glutaminase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009382 | cellular_component | imidazoleglycerol-phosphate synthase complex |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016829 | molecular_function | lyase activity |
| E | 0000105 | biological_process | L-histidine biosynthetic process |
| E | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000105 | biological_process | L-histidine biosynthetic process |
| F | 0000107 | molecular_function | imidazoleglycerol-phosphate synthase activity |
| F | 0004359 | molecular_function | glutaminase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009382 | cellular_component | imidazoleglycerol-phosphate synthase complex |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 1202 |
| Chain | Residue |
| A | GLU231 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1201 |
| Chain | Residue |
| B | PRO38 |
| B | ARG39 |
| B | ASN40 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLN B 1205 |
| Chain | Residue |
| B | GLU96 |
| B | VAL140 |
| B | HIS141 |
| B | THR142 |
| B | TYR143 |
| B | HOH2030 |
| B | HOH2036 |
| A | GLN123 |
| B | VAL51 |
| B | GLY52 |
| B | CYS84 |
| B | GLN88 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL B 1202 |
| Chain | Residue |
| B | LYS72 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 1254 |
| Chain | Residue |
| C | ASN148 |
| C | THR149 |
| C | GLY150 |
| C | HOH2035 |
| D | ASN26 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 1201 |
| Chain | Residue |
| D | LYS129 |
| D | ASP130 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GLN D 1205 |
| Chain | Residue |
| D | GLY52 |
| D | GLN88 |
| D | GLU96 |
| D | VAL140 |
| D | HIS141 |
| D | THR142 |
| D | TYR143 |
| D | HOH2029 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL E 1254 |
| Chain | Residue |
| E | ARG188 |
| E | LEU215 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 1255 |
| Chain | Residue |
| D | GLU36 |
| E | ARG188 |
| E | PHE189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 597 |
| Details | Domain: {"description":"Glutamine amidotransferase type-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Nucleophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Active site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 753 |
| Chain | Residue | Details |
| A | ASP11 | proton acceptor, proton donor |
| A | ASP130 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 753 |
| Chain | Residue | Details |
| C | ASP11 | proton acceptor, proton donor |
| C | ASP130 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 753 |
| Chain | Residue | Details |
| E | ASP11 | proton acceptor, proton donor |
| E | ASP130 | proton acceptor, proton donor |
