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3ZPU

Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B 1200
ChainResidue
BTRP106
BHOH2096

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1100
ChainResidue
ATHR74
AASN88
AHOH2046
BARG141

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1201
ChainResidue
BHOH2111
BGLY173
BTHR174
BASN188

site_idAC4
Number of Residues24
DetailsBINDING SITE FOR RESIDUE M8B B 1202
ChainResidue
AARG8
AASP25
AGLY27
AALA28
AASP29
AASP30
AILE47
AGLY48
AGLY49
AILE50
APRO81
AHOH2071
AHOH2098
BARG108
BLEU123
BASP125
BGLY127
BALA128
BASP129
BGLY148
BGLY149
BILE150
BTHR182
BHOH2086

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
ChainResidueDetails
AALA22-LEU33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029
ChainResidueDetails
AASP25
BASP125

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069
ChainResidueDetails
APHE99
BPHE199

223532

PDB entries from 2024-08-07

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