3ZPI

PikC D50N mutant in P21 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0017000	biological_process	antibiotic biosynthetic process
A	0020037	molecular_function	heme binding
A	0033068	biological_process	macrolide biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0055114	biological_process	obsolete oxidation-reduction process
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0017000	biological_process	antibiotic biosynthetic process
B	0020037	molecular_function	heme binding
B	0033068	biological_process	macrolide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0055114	biological_process	obsolete oxidation-reduction process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT B 1408

Chain	Residue
B	ASP222
B	HOH2294
B	HOH2296

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TLA A 1419

Chain	Residue
A	HOH2468
B	ARG60
B	ARG69
B	ASP303
B	HOH2083
A	PRO30
A	ARG34
A	EDO1415
A	HOH2464
A	HOH2465
A	HOH2466

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM B 1407

Chain	Residue
B	LYS72
B	MET92
B	LEU93
B	HIS100
B	ARG104
B	PHE111
B	ALA243
B	GLY244
B	THR247
B	THR248
B	LEU251
B	PRO289
B	ALA293
B	THR294
B	ARG296
B	ALA346
B	PHE347
B	GLY348
B	HIS352
B	CYS354
B	ILE355
B	GLY356
B	ALA360
B	HOH2312
B	HOH2385

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 1409

Chain	Residue
B	GLY343
B	HIS344
B	ARG361
B	EDO1410

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 1410

Chain	Residue
B	ARG62
B	GLY343
B	HIS344
B	EDO1409

---

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM A 1407

Chain	Residue
A	LYS72
A	MET92
A	LEU93
A	HIS100
A	ARG104
A	PHE111
A	ALA243
A	GLY244
A	THR247
A	THR248
A	LEU251
A	PRO289
A	ALA293
A	THR294
A	ARG296
A	ALA346
A	PHE347
A	GLY348
A	HIS352
A	CYS354
A	ILE355
A	GLY356
A	ALA360
A	HOH2365
A	HOH2434

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 1408

Chain	Residue
A	ARG104
A	ILE351
A	HOH2469
A	HOH2470

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 1409

Chain	Residue
A	ASP167

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1410

Chain	Residue
A	GLU223
A	EDO1411
A	HOH2343

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1411

Chain	Residue
A	GLU223
A	ASP224
A	EDO1410

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 1412

Chain	Residue
A	ARG270
A	MET273

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 1413

Chain	Residue
A	PRO330
A	ASP336
A	ARG339
A	HOH2420

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT B 1411

Chain	Residue
B	GLY350

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT B 1412

Chain	Residue
B	ASP209
B	HOH2280
B	HOH2282
B	HOH2405

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1414

Chain	Residue
A	ARG122
A	VAL156
A	GLU159
A	HOH2472

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1415

Chain	Residue
A	PHE24
A	ASP27
A	PRO30
A	TLA1419
A	HOH2040
A	HOH2473
A	ASP23

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 1416

Chain	Residue
A	MET145
A	ARG172
A	ASP176

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 1417

Chain	Residue
A	TYR29
A	ARG324
A	HIS333
A	HOH2046
A	HOH2395
A	HOH2474
B	ASP303
B	GLY306
B	VAL308

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 1418

Chain	Residue
A	GLU291
A	TYR390
A	PRO391
A	ASN392
A	ILE395
A	HOH2033
A	HOH2401

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHFCIG

Chain	Residue	Details
A	PHE347-GLY356

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16825192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19124459","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"16825192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19124459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19833867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24627965","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2C6H","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2C7X","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2CA0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2CD8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2VZ7","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2VZM","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2WHW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"2WI9","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3ZK5","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4B7D","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4B7S","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4BF4","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

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