3ZOK
Structure of 3-Dehydroquinate Synthase from Actinidia chinensis in complex with NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| B | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| C | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| D | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1378 |
| Chain | Residue |
| A | LYS156 |
| A | ASN166 |
| A | ASN258 |
| A | HIS265 |
| A | LYS337 |
| A | PO41379 |
| A | GLY1384 |
| B | ARG134 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1379 |
| Chain | Residue |
| A | HIS261 |
| A | HIS265 |
| A | HIS278 |
| A | PO41378 |
| A | NAD1381 |
| A | GLY1384 |
| A | ASN166 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1380 |
| Chain | Residue |
| A | ASN258 |
| A | LEU259 |
| A | GLY260 |
| A | HIS261 |
| A | THR262 |
| A | PHE263 |
| A | ALA289 |
| A | LYS338 |
| A | LEU346 |
| A | ILE347 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 1381 |
| Chain | Residue |
| A | ASN54 |
| A | THR56 |
| A | VAL57 |
| A | TYR61 |
| A | ASP85 |
| A | GLU87 |
| A | LYS90 |
| A | GLY118 |
| A | GLY119 |
| A | VAL120 |
| A | ASP123 |
| A | THR143 |
| A | THR144 |
| A | MET146 |
| A | ASP150 |
| A | SER151 |
| A | LYS156 |
| A | LYS165 |
| A | THR183 |
| A | THR186 |
| A | LEU187 |
| A | GLU191 |
| A | LYS240 |
| A | HIS278 |
| A | PO41379 |
| A | GLY1384 |
| A | HOH2006 |
| A | HOH2015 |
| A | HOH2027 |
| A | HOH2033 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 1382 |
| Chain | Residue |
| A | ASN71 |
| A | ALA334 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 1383 |
| Chain | Residue |
| A | LEU163 |
| A | MET328 |
| A | SER331 |
| B | ILE103 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1378 |
| Chain | Residue |
| A | ARG134 |
| B | LYS156 |
| B | ASN166 |
| B | ASN258 |
| B | HIS265 |
| B | LYS337 |
| B | PO41379 |
| B | GLY1385 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1379 |
| Chain | Residue |
| B | ASN166 |
| B | HIS261 |
| B | HIS265 |
| B | HIS278 |
| B | PO41378 |
| B | NAD1382 |
| B | GLY1385 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1380 |
| Chain | Residue |
| B | ASN258 |
| B | GLY260 |
| B | HIS261 |
| B | THR262 |
| B | PHE263 |
| B | ALA289 |
| B | LYS338 |
| B | LEU346 |
| B | ILE347 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1381 |
| Chain | Residue |
| B | LYS97 |
| B | 2PE1383 |
| D | LYS97 |
| site_id | BC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 1382 |
| Chain | Residue |
| B | THR143 |
| B | THR144 |
| B | MET146 |
| B | ASP150 |
| B | SER151 |
| B | LYS156 |
| B | LYS165 |
| B | ASN166 |
| B | THR183 |
| B | THR186 |
| B | LEU187 |
| B | GLU191 |
| B | LYS240 |
| B | HIS278 |
| B | PO41379 |
| B | GLY1385 |
| B | HOH2006 |
| B | HOH2016 |
| B | HOH2024 |
| B | ASN54 |
| B | THR56 |
| B | VAL57 |
| B | TYR61 |
| B | ASP85 |
| B | GLU87 |
| B | LYS90 |
| B | GLY118 |
| B | GLY119 |
| B | VAL120 |
| B | ASP123 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2PE B 1383 |
| Chain | Residue |
| B | PRO84 |
| B | ASP93 |
| B | LYS97 |
| B | PO41381 |
| B | HOH2038 |
| D | ILE82 |
| D | PRO84 |
| D | TYR89 |
| D | ASP93 |
| D | LYS97 |
| D | ASP100 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 1384 |
| Chain | Residue |
| A | ARG106 |
| B | LYS330 |
| B | ALA334 |
| B | GLY342 |
| B | HOH2040 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GLY B 1385 |
| Chain | Residue |
| B | LYS156 |
| B | LYS240 |
| B | ARG254 |
| B | LEU257 |
| B | PO41378 |
| B | PO41379 |
| B | NAD1382 |
| B | HOH2021 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1378 |
| Chain | Residue |
| C | ASN166 |
| C | HIS261 |
| C | HIS265 |
| C | HIS278 |
| C | PO41379 |
| C | NAD1381 |
| C | GLY1383 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1379 |
| Chain | Residue |
| C | LYS156 |
| C | ASN166 |
| C | ASN258 |
| C | HIS265 |
| C | LYS337 |
| C | PO41378 |
| D | ARG134 |
| site_id | BC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1380 |
| Chain | Residue |
| C | ASN258 |
| C | LEU259 |
| C | GLY260 |
| C | HIS261 |
| C | THR262 |
| C | PHE263 |
| C | ALA289 |
| C | LYS338 |
| C | LEU346 |
| C | ILE347 |
| site_id | BC9 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD C 1381 |
| Chain | Residue |
| C | ASN54 |
| C | THR56 |
| C | VAL57 |
| C | TYR61 |
| C | ASP85 |
| C | GLU87 |
| C | LYS90 |
| C | GLY118 |
| C | GLY119 |
| C | VAL120 |
| C | ASP123 |
| C | THR143 |
| C | THR144 |
| C | MET146 |
| C | ASP150 |
| C | SER151 |
| C | LYS156 |
| C | LYS165 |
| C | ASN166 |
| C | THR183 |
| C | THR186 |
| C | LEU187 |
| C | GLU191 |
| C | LYS240 |
| C | HIS278 |
| C | PO41378 |
| C | GLY1383 |
| C | HOH2006 |
| C | HOH2008 |
| C | HOH2034 |
| C | HOH2045 |
| C | HOH2053 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 C 1382 |
| Chain | Residue |
| C | LYS330 |
| C | ALA334 |
| C | GLY342 |
| D | ARG48 |
| D | SER105 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GLY C 1383 |
| Chain | Residue |
| C | LYS156 |
| C | LYS240 |
| C | ARG254 |
| C | PO41378 |
| C | NAD1381 |
| C | HOH2030 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1378 |
| Chain | Residue |
| D | ASN166 |
| D | HIS261 |
| D | HIS265 |
| D | HIS278 |
| D | PO41379 |
| D | NAD1382 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1379 |
| Chain | Residue |
| C | ARG134 |
| D | LYS156 |
| D | ASN166 |
| D | ASN258 |
| D | HIS265 |
| D | LYS337 |
| D | PO41378 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1380 |
| Chain | Residue |
| D | ASN258 |
| D | GLY260 |
| D | HIS261 |
| D | THR262 |
| D | PHE263 |
| D | ALA289 |
| D | LYS338 |
| D | LEU346 |
| D | ILE347 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1381 |
| Chain | Residue |
| D | TYR231 |
| D | LYS234 |
| D | ARG235 |
| D | GLU238 |
| site_id | CC7 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD D 1382 |
| Chain | Residue |
| D | ASN54 |
| D | THR56 |
| D | VAL57 |
| D | TYR61 |
| D | ASP85 |
| D | GLU87 |
| D | LYS90 |
| D | GLY118 |
| D | GLY119 |
| D | VAL120 |
| D | ASP123 |
| D | THR143 |
| D | THR144 |
| D | MET146 |
| D | ASP150 |
| D | SER151 |
| D | LYS156 |
| D | LYS165 |
| D | THR183 |
| D | THR186 |
| D | LEU187 |
| D | GLU191 |
| D | LYS240 |
| D | HIS278 |
| D | PO41378 |
| D | HOH2008 |
| D | HOH2015 |
| D | HOH2028 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 1383 |
| Chain | Residue |
| A | LYS97 |
| D | THR269 |
| D | GLY270 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG D 1384 |
| Chain | Residue |
| C | LEU163 |
| C | SER331 |
| D | ILE103 |
| D | GLU104 |
| D | ARG106 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG D 1385 |
| Chain | Residue |
| C | ARG106 |
| C | HOH2012 |
| D | LYS330 |
| D | ALA334 |
| D | VAL339 |
| D | GLY342 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GLY D 1386 |
| Chain | Residue |
| D | ASN185 |
| D | THR186 |
| D | LEU187 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GLY A 1384 |
| Chain | Residue |
| A | ASP150 |
| A | LYS156 |
| A | LYS240 |
| A | ARG254 |
| A | PO41378 |
| A | PO41379 |
| A | NAD1381 |
| A | HOH2025 |
| A | HOH2028 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GLY D 1386 |
| Chain | Residue |
| D | ASN185 |
| D | THR186 |
| D | LEU187 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GLY D 1387 |
| Chain | Residue |
| D | LYS350 |
| D | ASP361 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23916589, ECO:0007744|PDB:3ZOK |
| Chain | Residue | Details |
| A | ASN54 | |
| B | ASP85 | |
| B | LYS90 | |
| B | GLY118 | |
| B | THR143 | |
| B | LYS165 | |
| B | THR183 | |
| B | LYS240 | |
| C | ASN54 | |
| C | ASP85 | |
| C | LYS90 | |
| A | ASP85 | |
| C | GLY118 | |
| C | THR143 | |
| C | LYS165 | |
| C | THR183 | |
| C | LYS240 | |
| D | ASN54 | |
| D | ASP85 | |
| D | LYS90 | |
| D | GLY118 | |
| D | THR143 | |
| A | LYS90 | |
| D | LYS165 | |
| D | THR183 | |
| D | LYS240 | |
| A | GLY118 | |
| A | THR143 | |
| A | LYS165 | |
| A | THR183 | |
| A | LYS240 | |
| B | ASN54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23916589 |
| Chain | Residue | Details |
| A | LYS156 | |
| B | LYS156 | |
| C | LYS156 | |
| D | LYS156 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU198 | |
| D | GLU198 | |
| D | HIS261 | |
| D | HIS278 | |
| A | HIS261 | |
| A | HIS278 | |
| B | GLU198 | |
| B | HIS261 | |
| B | HIS278 | |
| C | GLU198 | |
| C | HIS261 | |
| C | HIS278 |
