3ZNX

Crystal structure of the OTU domain of OTULIN D336A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1346

Chain	Residue
A	SER163
A	GLU209
A	HOH2208
A	HOH2212

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1347

Chain	Residue
A	LYS94
A	VAL318

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1348

Chain	Residue
A	GLY270
A	GLN271
A	ARG274
A	HOH2161
A	HOH2327
A	TRP167
A	ASP268
A	PRO269

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1349

Chain	Residue
A	LEU235
A	ASN238
A	ARG239
A	GLU242
A	HOH2123
A	HOH2230
A	HOH2329

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1350

Chain	Residue
A	HIS276
A	GLN279
A	VAL280
A	GLY285
A	GLU287
A	GLU290
A	HOH2269

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	ASP126
A	HIS339

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:24726327, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	CYS129

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Linear diubiquitin binding => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSK, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	GLU314

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