3ZNO

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003884	molecular_function	D-amino-acid oxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006562	biological_process	L-proline catabolic process
A	0007586	biological_process	digestion
A	0008718	molecular_function	D-amino-acid dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0019478	biological_process	D-amino acid catabolic process
A	0036088	biological_process	D-serine catabolic process
A	0042416	biological_process	dopamine biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0043799	molecular_function	glycine oxidase activity
A	0046416	biological_process	D-amino acid metabolic process
A	0048786	cellular_component	presynaptic active zone
A	0051873	biological_process	killing by host of symbiont cells
A	0055130	biological_process	D-alanine catabolic process
A	0070178	biological_process	D-serine metabolic process
A	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
A	0071949	molecular_function	FAD binding
A	0170035	biological_process	L-amino acid catabolic process
A	0170040	biological_process	proteinogenic amino acid catabolic process
B	0003884	molecular_function	D-amino-acid oxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006562	biological_process	L-proline catabolic process
B	0007586	biological_process	digestion
B	0008718	molecular_function	D-amino-acid dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0019478	biological_process	D-amino acid catabolic process
B	0036088	biological_process	D-serine catabolic process
B	0042416	biological_process	dopamine biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0043799	molecular_function	glycine oxidase activity
B	0046416	biological_process	D-amino acid metabolic process
B	0048786	cellular_component	presynaptic active zone
B	0051873	biological_process	killing by host of symbiont cells
B	0055130	biological_process	D-alanine catabolic process
B	0070178	biological_process	D-serine metabolic process
B	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
B	0071949	molecular_function	FAD binding
B	0170035	biological_process	L-amino acid catabolic process
B	0170040	biological_process	proteinogenic amino acid catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	41
Details	BINDING SITE FOR RESIDUE FAD A 350

Chain	Residue
A	ILE6
A	THR43
A	THR44
A	THR45
A	VAL47
A	ALA48
A	ALA49
A	GLY50
A	LEU51
A	ARG162
A	LYS163
A	GLY7
A	VAL164
A	CYS181
A	THR182
A	GLY183
A	TRP185
A	ILE202
A	TYR228
A	GLY281
A	ARG283
A	HIS311
A	ALA8
A	GLY312
A	GLY313
A	TYR314
A	GLY315
A	LEU316
A	THR317
A	SE5360
A	HOH537
A	HOH579
A	HOH581
A	GLY9
A	HOH582
A	HOH601
A	VAL10
A	ILE11
A	ALA36
A	ASP37
A	ARG38

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SE5 A 360

Chain	Residue
A	LEU56
A	LEU215
A	ILE223
A	TYR224
A	TYR228
A	ILE230
A	ARG283
A	GLY313
A	FAD350

---

site_id	AC3
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD B 350

Chain	Residue
B	ILE6
B	GLY7
B	ALA8
B	GLY9
B	VAL10
B	ILE11
B	ALA36
B	ASP37
B	ARG38
B	THR44
B	THR45
B	ALA48
B	GLY50
B	LEU51
B	ARG162
B	VAL164
B	CYS181
B	THR182
B	GLY183
B	TRP185
B	ILE202
B	TYR228
B	ARG283
B	GLY312
B	GLY313
B	TYR314
B	GLY315
B	LEU316
B	THR317
B	SE5360
B	HOH526
B	HOH591

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SE5 B 360

Chain	Residue
B	HIS217
B	ILE223
B	TYR224
B	TYR228
B	ARG283
B	GLY313
B	FAD350

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1341

Chain	Residue
A	HIS212
A	GLU267
A	HOH567
B	HIS80
B	LEU91

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pg.TQtVTLGGI

Chain	Residue	Details
A	PRO231-ILE241

---

site_id	PS00677
Number of Residues	19
Details	DAO D-amino acid oxidases signature. VIHNYGhGGyGltihwGcA

Chain	Residue	Details
A	VAL305-ALA323

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Region: {"description":"Required for protein stability","evidences":[{"source":"PubMed","id":"33484270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"Active site lid that may open upon substrate/product migration in and out of the active site and close to increase the hydrophobicity of the active site, to make the hydride transfer reaction more efficient","evidences":[{"source":"UniProtKB","id":"P00371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38035964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17088322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17303072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18455394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19438227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23566269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23631755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25001371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30265959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32730563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DU8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7U9U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---