3znn

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003884	molecular_function	D-amino-acid oxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006562	biological_process	proline catabolic process
A	0007586	biological_process	digestion
A	0016491	molecular_function	oxidoreductase activity
A	0019478	biological_process	D-amino acid catabolic process
A	0036088	biological_process	D-serine catabolic process
A	0042416	biological_process	dopamine biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0045202	cellular_component	synapse
A	0046416	biological_process	D-amino acid metabolic process
A	0048786	cellular_component	presynaptic active zone
A	0055130	biological_process	D-alanine catabolic process
A	0070178	biological_process	D-serine metabolic process
A	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
A	0071949	molecular_function	FAD binding
B	0003884	molecular_function	D-amino-acid oxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006562	biological_process	proline catabolic process
B	0007586	biological_process	digestion
B	0016491	molecular_function	oxidoreductase activity
B	0019478	biological_process	D-amino acid catabolic process
B	0036088	biological_process	D-serine catabolic process
B	0042416	biological_process	dopamine biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0045202	cellular_component	synapse
B	0046416	biological_process	D-amino acid metabolic process
B	0048786	cellular_component	presynaptic active zone
B	0055130	biological_process	D-alanine catabolic process
B	0070178	biological_process	D-serine metabolic process
B	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
B	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD A 350

Chain	Residue
A	GLY7
A	THR44
A	THR45
A	ALA48
A	ALA49
A	GLY50
A	LEU51
A	ARG162
A	LYS163
A	VAL164
A	CYS181
A	ALA8
A	THR182
A	GLY183
A	TRP185
A	ILE202
A	TYR228
A	ARG283
A	HIS311
A	GLY312
A	GLY313
A	TYR314
A	GLY9
A	GLY315
A	LEU316
A	THR317
A	4WL360
A	GOL1343
A	HOH2011
A	HOH2016
A	HOH2048
A	HOH2094
A	VAL10
A	ILE11
A	ALA36
A	ASP37
A	ARG38
A	THR43

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 4WL A 360

Chain	Residue
A	LEU51
A	TYR224
A	TYR228
A	ILE230
A	ARG283
A	GLY313
A	FAD350
A	GOL1345

site_id	AC3
Number of Residues	36
Details	BINDING SITE FOR RESIDUE FAD B 350

Chain	Residue
B	GLY7
B	ALA8
B	GLY9
B	VAL10
B	ILE11
B	ALA36
B	ASP37
B	ARG38
B	THR43
B	THR44
B	THR45
B	ALA48
B	ALA49
B	GLY50
B	LEU51
B	ARG162
B	VAL164
B	CYS181
B	THR182
B	GLY183
B	TRP185
B	ILE202
B	TYR228
B	ARG283
B	GLY312
B	GLY313
B	TYR314
B	GLY315
B	LEU316
B	THR317
B	4WL360
B	HOH2029
B	HOH2058
B	HOH2060
B	HOH2062
B	HOH2078

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 4WL B 360

Chain	Residue
B	LEU51
B	GLN53
B	TYR224
B	TYR228
B	ILE230
B	ARG283
B	GLY313
B	FAD350

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1341

Chain	Residue
A	LYS158
A	PHE159
A	PHE160

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1341

Chain	Residue
B	PRO193
B	LEU194
B	GLN196
B	PRO287
B	HOH2145

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1342

Chain	Residue
A	HIS99
A	GLU100
A	ILE102
A	HIS217
A	PRO219
A	HOH2073
A	PHE98

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1342

Chain	Residue
A	PRO300
B	GLY187
B	ARG191
B	ASP192
B	PRO193
B	LEU339

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1343

Chain	Residue
A	ASP37
A	ARG38
A	LYS163
A	TRP185
A	FAD350
A	GOL1346
A	HOH2085

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1344

Chain	Residue
A	THR45
A	ASP46
A	ALA48
A	ALA49
A	GLU140
A	GLY141
A	LYS142
A	LYS204

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1345

Chain	Residue
A	GLN53
A	PRO54
A	LEU56
A	HIS217
A	4WL360
A	HOH2068
A	HOH2123

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1346

Chain	Residue
A	TRP185
A	TRP247
A	GLU249
A	PHE282
A	GOL1343

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1343

Chain	Residue
B	HIS99
B	ASP127
B	TYR128
B	GLY129
B	HOH2031
B	HOH2081

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1344

Chain	Residue
A	HIS80
B	ASP123
B	MET124
B	PRO126

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1347

Chain	Residue
A	GLU294
A	GLN295

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pg.TQtVTLGGI

Chain	Residue	Details
A	PRO231-ILE241

site_id	PS00677
Number of Residues	19
Details	DAO D-amino acid oxidases signature. VIHNYGhGGyGltihwGcA

Chain	Residue	Details
A	VAL305-ALA323

Functional Information from SwissProt/UniProt

Chain	Residue	Details
A	ALA8
A	ILE11
B	ALA8
B	ILE11

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17303072, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82

Chain	Residue	Details
A	GLY9
B	GLY9

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNQ

Chain	Residue	Details
A	VAL10
B	VAL10

Chain	Residue	Details
A	ASP37
B	ASP37

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJ9, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:6KBP, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

Chain	Residue	Details
A	ARG38
B	VAL164
B	GLY312
B	THR317
A	THR45
A	LEU51
A	VAL164
A	GLY312
A	THR317
B	ARG38
B	THR45
B	LEU51

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:18455394, ECO:0007744\|PDB:3CUK

Chain	Residue	Details
A	THR43
B	THR43

Chain	Residue	Details
A	THR44
B	THR44

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00371

Chain	Residue	Details
A	ALA49
A	LYS163
B	ALA49
B	LYS163

Chain	Residue	Details
A	GLY50
B	GLY50

site_id	SWS_FT_FI10
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17303072, ECO:0007744\|PDB:2E82

Chain	Residue	Details
A	GLN53
B	GLN53

site_id	SWS_FT_FI11
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:3ZNQ

Chain	Residue	Details
A	THR182
B	THR182

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:17303072, ECO:0007744\|PDB:2E4A

Chain	Residue	Details
A	TYR224
B	TYR224

site_id	SWS_FT_FI13
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:17088322, ECO:0000305\|PubMed:17303072, ECO:0000305\|PubMed:18455394, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:3CUK

Chain	Residue	Details
A	TYR228
B	TYR228

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNO

Chain	Residue	Details
A	ARG283
B	ARG283

site_id	SWS_FT_FI15
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFD

Chain	Residue	Details
A	GLY313
B	GLY313

Chain	Residue	Details
A	GLY315
B	GLY315

Chain	Residue	Details
A	LEU316
B	LEU316

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJ9, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:6KBP, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJ9, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:6KBP, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0000269\|PubMed:38035964, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:5ZJ9, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:6KBP, ECO:0007744\|PDB:7U9S, ECO:0007744\|PDB:7U9U, ECO:0007744\|PDB:8HY5

site_id	SWS_FT_FI17
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072, ECO:0000269\|PubMed:18455394, ECO:0000269\|PubMed:19438227, ECO:0000269\|PubMed:23566269, ECO:0000269\|PubMed:23631755, ECO:0000269\|PubMed:25001371, ECO:0000269\|PubMed:30265959, ECO:0000269\|PubMed:32730563, ECO:0000269\|PubMed:35482677, ECO:0007744\|PDB:2DU8, ECO:0007744\|PDB:2E48, ECO:0007744\|PDB:2E49, ECO:0007744\|PDB:2E4A, ECO:0007744\|PDB:2E82, ECO:0007744\|PDB:3CUK, ECO:0007744\|PDB:3G3E, ECO:0007744\|PDB:3W4I, ECO:0007744\|PDB:3W4J, ECO:0007744\|PDB:3W4K, ECO:0007744\|PDB:3ZNN, ECO:0007744\|PDB:3ZNO, ECO:0007744\|PDB:3ZNP, ECO:0007744\|PDB:3ZNQ, ECO:0007744\|PDB:4QFC, ECO:0007744\|PDB:4QFD, ECO:0007744\|PDB:5ZJ9, ECO:0007744\|PDB:5ZJA, ECO:0007744\|PDB:6KBP, ECO:0007744\|PDB:7U9U

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN