Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ZMS

LSD1-CoREST in complex with INSM1 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016491	molecular_function	oxidoreductase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0000118	cellular_component	histone deacetylase complex
B	0003682	molecular_function	chromatin binding
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005667	cellular_component	transcription regulator complex
B	0006325	biological_process	chromatin organization
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0010629	biological_process	negative regulation of gene expression
B	0017053	cellular_component	transcription repressor complex
B	0019899	molecular_function	enzyme binding
B	0030218	biological_process	erythrocyte differentiation
B	0045654	biological_process	positive regulation of megakaryocyte differentiation
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	1990391	cellular_component	DNA repair complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0003309	biological_process	type B pancreatic cell differentiation
C	0003310	biological_process	pancreatic A cell differentiation
C	0003323	biological_process	type B pancreatic cell development
C	0003358	biological_process	noradrenergic neuron development
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0007049	biological_process	cell cycle
C	0007399	biological_process	nervous system development
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0010468	biological_process	regulation of gene expression
C	0010564	biological_process	regulation of cell cycle process
C	0016477	biological_process	cell migration
C	0017053	cellular_component	transcription repressor complex
C	0030154	biological_process	cell differentiation
C	0030182	biological_process	neuron differentiation
C	0030332	molecular_function	cyclin binding
C	0030335	biological_process	positive regulation of cell migration
C	0031018	biological_process	endocrine pancreas development
C	0031490	molecular_function	chromatin DNA binding
C	0035270	biological_process	endocrine system development
C	0042421	biological_process	norepinephrine biosynthetic process
C	0042826	molecular_function	histone deacetylase binding
C	0043254	biological_process	regulation of protein-containing complex assembly
C	0045597	biological_process	positive regulation of cell differentiation
C	0046872	molecular_function	metal ion binding
C	0051726	biological_process	regulation of cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0060290	biological_process	transdifferentiation
C	0061104	biological_process	adrenal chromaffin cell differentiation
C	0061549	biological_process	sympathetic ganglion development
C	2000179	biological_process	positive regulation of neural precursor cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD A 900

Chain	Residue
A	GLY285
A	GLY315
A	ARG316
A	LEU329
A	GLY330
A	ALA331
A	MET332
A	VAL333
A	THR588
A	VAL590
A	THR624
A	GLY287
A	LEU625
A	PRO626
A	VAL637
A	LEU659
A	TRP756
A	SER760
A	TYR761
A	GLY800
A	GLU801
A	ALA809
A	VAL288
A	THR810
A	VAL811
A	ALA814
C	PHE4
A	SER289
A	LEU307
A	GLU308
A	ALA309
A	ARG310
A	GLY314

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpe..CakvFscpanlasHrrw..H

Chain	Residue	Details
C	CYS296-HIS316
C	CYS368-HIS389
C	CYS442-HIS463
C	CYS470-HIS491

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ZN_FING: C2H2-type 1; atypical => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE266-CYS286
A	GLU308
A	ARG310
A	ARG316
A	MET332
A	GLU801
A	THR810

site_id	SWS_FT_FI2
Number of Residues	22
Details	ZN_FING: C2H2-type 2 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	TYR294-HIS316

site_id	SWS_FT_FI3
Number of Residues	22
Details	ZN_FING: C2H2-type 3 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	TYR366-HIS388

site_id	SWS_FT_FI4
Number of Residues	23
Details	ZN_FING: C2H2-type 4 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	HIS440-HIS463
B	LYS297
B	GLU466

site_id	SWS_FT_FI5
Number of Residues	23
Details	ZN_FING: C2H2-type 5 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE468-HIS491

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	TYR115

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER117

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18220336, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER146

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER611

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER849

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS442
A	LYS469

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:25018020

Chain	Residue	Details
A	LYS503

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)