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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3ZMS

LSD1-CoREST in complex with INSM1 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
A0016491molecular_functionoxidoreductase activity
A0050660molecular_functionflavin adenine dinucleotide binding
B0000118cellular_componenthistone deacetylase complex
B0003682molecular_functionchromatin binding
B0003714molecular_functiontranscription corepressor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0006325biological_processchromatin organization
B0006357biological_processregulation of transcription by RNA polymerase II
B0010629biological_processnegative regulation of gene expression
B0017053cellular_componenttranscription repressor complex
B0019899molecular_functionenzyme binding
B0030218biological_processerythrocyte differentiation
B0035097cellular_componenthistone methyltransferase complex
B0045654biological_processpositive regulation of megakaryocyte differentiation
B0045892biological_processnegative regulation of DNA-templated transcription
B1990391cellular_componentDNA repair complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
C0001933biological_processnegative regulation of protein phosphorylation
C0003309biological_processtype B pancreatic cell differentiation
C0003310biological_processpancreatic A cell differentiation
C0003358biological_processnoradrenergic neuron development
C0003677molecular_functionDNA binding
C0003700molecular_functionDNA-binding transcription factor activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0007399biological_processnervous system development
C0008270molecular_functionzinc ion binding
C0008285biological_processnegative regulation of cell population proliferation
C0010468biological_processregulation of gene expression
C0010564biological_processregulation of cell cycle process
C0017053cellular_componenttranscription repressor complex
C0030154biological_processcell differentiation
C0030182biological_processneuron differentiation
C0030332molecular_functioncyclin binding
C0031490molecular_functionchromatin DNA binding
C0042127biological_processregulation of cell population proliferation
C0042421biological_processnorepinephrine biosynthetic process
C0042826molecular_functionhistone deacetylase binding
C0043254biological_processregulation of protein-containing complex assembly
C0045597biological_processpositive regulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0051726biological_processregulation of cell cycle
C0060090molecular_functionmolecular adaptor activity
C0060290biological_processtransdifferentiation
C0061104biological_processadrenal chromaffin cell differentiation
C0061549biological_processsympathetic ganglion development
C2000179biological_processpositive regulation of neural precursor cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues33
DetailsBINDING SITE FOR RESIDUE FAD A 900
ChainResidue
AGLY285
AGLY315
AARG316
ALEU329
AGLY330
AALA331
AMET332
AVAL333
ATHR588
AVAL590
ATHR624
AGLY287
ALEU625
APRO626
AVAL637
ALEU659
ATRP756
ASER760
ATYR761
AGLY800
AGLU801
AALA809
AVAL288
ATHR810
AVAL811
AALA814
CPHE4
ASER289
ALEU307
AGLU308
AALA309
AARG310
AGLY314
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpe..CakvFscpanlasHrrw..H
ChainResidueDetails
CCYS296-HIS316
CCYS368-HIS389
CCYS442-HIS463
CCYS470-HIS491
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues99
DetailsDomain: {"description":"SWIRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00247","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues121
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16885027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16956976","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21300290","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23721412","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IW5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZN1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"27292636","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25018020","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues51
DetailsDomain: {"description":"SANT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00624","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues5
DetailsRegion: {"description":"Required and sufficient for interaction with KDM1A","evidences":[{"source":"PubMed","id":"23721412","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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