3ZMS
LSD1-CoREST in complex with INSM1 peptide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0000118 | cellular_component | histone deacetylase complex |
B | 0003682 | molecular_function | chromatin binding |
B | 0003714 | molecular_function | transcription corepressor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005667 | cellular_component | transcription regulator complex |
B | 0006325 | biological_process | chromatin organization |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0010629 | biological_process | negative regulation of gene expression |
B | 0017053 | cellular_component | transcription repressor complex |
B | 0019899 | molecular_function | enzyme binding |
B | 0030218 | biological_process | erythrocyte differentiation |
B | 0045654 | biological_process | positive regulation of megakaryocyte differentiation |
B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
B | 1990391 | cellular_component | DNA repair complex |
C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
C | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
C | 0001227 | molecular_function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
C | 0001933 | biological_process | negative regulation of protein phosphorylation |
C | 0003309 | biological_process | type B pancreatic cell differentiation |
C | 0003310 | biological_process | pancreatic A cell differentiation |
C | 0003323 | biological_process | type B pancreatic cell development |
C | 0003358 | biological_process | noradrenergic neuron development |
C | 0003677 | molecular_function | DNA binding |
C | 0003700 | molecular_function | DNA-binding transcription factor activity |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0007399 | biological_process | nervous system development |
C | 0008283 | biological_process | cell population proliferation |
C | 0008284 | biological_process | positive regulation of cell population proliferation |
C | 0008285 | biological_process | negative regulation of cell population proliferation |
C | 0010468 | biological_process | regulation of gene expression |
C | 0010564 | biological_process | regulation of cell cycle process |
C | 0016477 | biological_process | cell migration |
C | 0017053 | cellular_component | transcription repressor complex |
C | 0030154 | biological_process | cell differentiation |
C | 0030182 | biological_process | neuron differentiation |
C | 0030332 | molecular_function | cyclin binding |
C | 0030335 | biological_process | positive regulation of cell migration |
C | 0031018 | biological_process | endocrine pancreas development |
C | 0031490 | molecular_function | chromatin DNA binding |
C | 0035270 | biological_process | endocrine system development |
C | 0042421 | biological_process | norepinephrine biosynthetic process |
C | 0042826 | molecular_function | histone deacetylase binding |
C | 0043254 | biological_process | regulation of protein-containing complex assembly |
C | 0045597 | biological_process | positive regulation of cell differentiation |
C | 0046872 | molecular_function | metal ion binding |
C | 0051726 | biological_process | regulation of cell cycle |
C | 0060090 | molecular_function | molecular adaptor activity |
C | 0060290 | biological_process | transdifferentiation |
C | 0061104 | biological_process | adrenal chromaffin cell differentiation |
C | 0061549 | biological_process | sympathetic ganglion development |
C | 2000179 | biological_process | positive regulation of neural precursor cell proliferation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE FAD A 900 |
Chain | Residue |
A | GLY285 |
A | GLY315 |
A | ARG316 |
A | LEU329 |
A | GLY330 |
A | ALA331 |
A | MET332 |
A | VAL333 |
A | THR588 |
A | VAL590 |
A | THR624 |
A | GLY287 |
A | LEU625 |
A | PRO626 |
A | VAL637 |
A | LEU659 |
A | TRP756 |
A | SER760 |
A | TYR761 |
A | GLY800 |
A | GLU801 |
A | ALA809 |
A | VAL288 |
A | THR810 |
A | VAL811 |
A | ALA814 |
C | PHE4 |
A | SER289 |
A | LEU307 |
A | GLU308 |
A | ALA309 |
A | ARG310 |
A | GLY314 |
Functional Information from PROSITE/UniProt
site_id | PS00028 |
Number of Residues | 21 |
Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpe..CakvFscpanlasHrrw..H |
Chain | Residue | Details |
C | CYS296-HIS316 | |
C | CYS368-HIS389 | |
C | CYS442-HIS463 | |
C | CYS470-HIS491 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | ZN_FING: C2H2-type 1; atypical => ECO:0000255|PROSITE-ProRule:PRU00042 |
Chain | Residue | Details |
C | PHE266-CYS286 | |
A | GLU308 | |
A | ARG310 | |
A | ARG316 | |
A | MET332 | |
A | GLU801 | |
A | THR810 |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042 |
Chain | Residue | Details |
C | TYR294-HIS316 |
site_id | SWS_FT_FI3 |
Number of Residues | 22 |
Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042 |
Chain | Residue | Details |
C | TYR366-HIS388 |
site_id | SWS_FT_FI4 |
Number of Residues | 23 |
Details | ZN_FING: C2H2-type 4 => ECO:0000255|PROSITE-ProRule:PRU00042 |
Chain | Residue | Details |
C | HIS440-HIS463 | |
B | LYS297 | |
B | GLU466 |
site_id | SWS_FT_FI5 |
Number of Residues | 23 |
Details | ZN_FING: C2H2-type 5 => ECO:0000255|PROSITE-ProRule:PRU00042 |
Chain | Residue | Details |
C | PHE468-HIS491 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | TYR115 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER117 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER146 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27292636 |
Chain | Residue | Details |
A | LYS432 | |
A | LYS433 | |
A | LYS436 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER611 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER849 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS442 | |
A | LYS469 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020 |
Chain | Residue | Details |
A | LYS503 |