3ZLH

Structure of group A Streptococcal enolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000015	cellular_component	phosphopyruvate hydratase complex
A	0000287	molecular_function	magnesium ion binding
A	0004634	molecular_function	phosphopyruvate hydratase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006096	biological_process	glycolytic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009986	cellular_component	cell surface
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0000015	cellular_component	phosphopyruvate hydratase complex
B	0000287	molecular_function	magnesium ion binding
B	0004634	molecular_function	phosphopyruvate hydratase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006096	biological_process	glycolytic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009986	cellular_component	cell surface
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
C	0000015	cellular_component	phosphopyruvate hydratase complex
C	0000287	molecular_function	magnesium ion binding
C	0004634	molecular_function	phosphopyruvate hydratase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006096	biological_process	glycolytic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0009986	cellular_component	cell surface
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0000015	cellular_component	phosphopyruvate hydratase complex
D	0000287	molecular_function	magnesium ion binding
D	0004634	molecular_function	phosphopyruvate hydratase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006096	biological_process	glycolytic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009986	cellular_component	cell surface
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00164
Number of Residues	14
Details	ENOLASE Enolase signature. ILIKvNQIGTLTET

Chain	Residue	Details
A	ILE341-THR354

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00318

Chain	Residue	Details
A	GLU205
B	GLU205
C	GLU205
D	GLU205

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00318

Chain	Residue	Details
A	LYS344
B	LYS344
C	LYS344
D	LYS344

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site_id	SWS_FT_FI3
Number of Residues	28
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00318

Chain	Residue	Details
B	SER371
B	LYS395
C	HIS155
C	GLU164
C	ASP243
C	GLU292
C	ASP319
C	SER371
C	LYS395
D	HIS155
D	GLU164
D	ASP243
D	GLU292
D	ASP319
D	SER371
D	LYS395
A	HIS155
A	GLU164
A	ASP243
A	GLU292
A	ASP319
A	SER371
A	LYS395
B	HIS155
B	GLU164
B	ASP243
B	GLU292
B	ASP319

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: covalent; in inhibited form => ECO:0000255|HAMAP-Rule:MF_00318

Chain	Residue	Details
A	LYS344
B	LYS344
C	LYS344
D	LYS344

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site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Important for binding of plasminogen

Chain	Residue	Details
B	LYS434
B	LYS435
C	LYS428
C	LYS434
C	LYS435
D	LYS428
D	LYS434
D	LYS435
A	LYS428
A	LYS434
A	LYS435
B	LYS428

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