Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ZL5

Crystal structure of Schistosoma mansoni Peroxiredoxin I C48S mutant with one decamer in the ASU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0033554	biological_process	cellular response to stress
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0033554	biological_process	cellular response to stress
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0033554	biological_process	cellular response to stress
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0033554	biological_process	cellular response to stress
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0033554	biological_process	cellular response to stress
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0033554	biological_process	cellular response to stress
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0033554	biological_process	cellular response to stress
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0033554	biological_process	cellular response to stress
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0098869	biological_process	cellular oxidant detoxification
I	0004601	molecular_function	peroxidase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0033554	biological_process	cellular response to stress
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0098869	biological_process	cellular oxidant detoxification
J	0004601	molecular_function	peroxidase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0033554	biological_process	cellular response to stress
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1165

Chain	Residue
A	THR45
A	PHE46
A	VAL47
A	SER48
A	ARG124

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1165

Chain	Residue
C	THR45
C	SER48
C	ARG124

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 1164

Chain	Residue
H	PHE46
H	VAL47
H	SER48
H	ARG124
H	THR45

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 J 1165

Chain	Residue
J	PRO41
J	THR45
J	PHE46
J	VAL47
J	SER48
J	ARG124
J	LYS143
J	SO41166

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 J 1166

Chain	Residue
A	TYR78
J	ASN121
J	SO41165

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 I 1164

Chain	Residue
I	THR45
I	PHE46
I	VAL47
I	SER48
I	ARG124
I	HOH2005
I	HOH2019

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 1165

Chain	Residue
I	ASP87
I	ARG88
I	LYS89
I	SO41166

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 1164

Chain	Residue
E	THR45
E	PHE46
E	VAL47
E	SER48
E	ARG124
E	HOH2009

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1165

Chain	Residue
D	THR45
D	PHE46
D	VAL47
D	SER48
D	ARG124
D	HOH2011

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 1164

Chain	Residue
F	THR45
F	PHE46
F	VAL47
F	SER48
F	ARG124
F	PEG1166

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 1164

Chain	Residue
G	THR45
G	PHE46
G	VAL47
G	SER48
G	ARG124

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 1166

Chain	Residue
E	TYR78
I	LYS89
I	SO41165
I	HOH2024

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG F 1165

Chain	Residue
E	GLU151
E	LEU155
F	THR139
F	ARG147
F	SER148
F	GLU151
F	THR152
F	LEU155

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG I 1167

Chain	Residue
H	TYR78
I	ASP119
I	ASN121
I	LYS143

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG H 1165

Chain	Residue
H	VAL2
H	LEU3
H	LEU4
H	ARG7
H	PRO8

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG F 1166

Chain	Residue
F	PHE46
F	SO41164

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)