3ZJC

Crystal structure of GMPPNP-bound human GIMAP7 L100Q variant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005811	cellular_component	lipid droplet
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046039	biological_process	GTP metabolic process
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005811	cellular_component	lipid droplet
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046039	biological_process	GTP metabolic process
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005811	cellular_component	lipid droplet
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046039	biological_process	GTP metabolic process
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005811	cellular_component	lipid droplet
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0046039	biological_process	GTP metabolic process
E	0000166	molecular_function	nucleotide binding
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005811	cellular_component	lipid droplet
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0046039	biological_process	GTP metabolic process
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005811	cellular_component	lipid droplet
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0046039	biological_process	GTP metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1294

Chain	Residue
B	SER22
B	THR44
B	GNP1295

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1296

Chain	Residue
A	SER22
A	THR44
A	ASP63
A	GNP1297

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 1294

Chain	Residue
C	GNP1295
C	SER22
C	THR44

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 1300

Chain	Residue
D	SER22
D	THR44
D	GNP1301

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 1292

Chain	Residue
F	SER22
F	THR44
F	GNP1293

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 1298

Chain	Residue
E	SER22
E	THR44
E	GNP1299

---

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP A 1297

Chain	Residue
A	THR17
A	GLY18
A	SER19
A	GLY20
A	LYS21
A	SER22
A	ALA23
A	SER36
A	ARG37
A	ILE38
A	VAL43
A	THR44
A	ARG133
A	GLU135
A	PHE167
A	SER168
A	ASN169
A	MG1296
B	ARG103

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP B 1295

Chain	Residue
B	GLY18
B	SER19
B	GLY20
B	LYS21
B	SER22
B	ALA23
B	SER36
B	ARG37
B	ILE38
B	ALA42
B	VAL43
B	THR44
B	ARG133
B	GLU135
B	PHE167
B	SER168
B	ASN169
B	MG1294

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP E 1299

Chain	Residue
E	THR17
E	GLY18
E	SER19
E	GLY20
E	LYS21
E	SER22
E	ALA23
E	SER36
E	ARG37
E	ILE38
E	VAL43
E	THR44
E	THR132
E	ARG133
E	GLU135
E	PHE167
E	ASN169
E	MG1298

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GNP D 1301

Chain	Residue
D	THR17
D	GLY18
D	SER19
D	GLY20
D	LYS21
D	SER22
D	ALA23
D	SER36
D	ARG37
D	ILE38
D	VAL43
D	THR44
D	THR132
D	ARG133
D	GLU135
D	PHE167
D	ASN169
D	MG1300

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP F 1293

Chain	Residue
F	SER36
F	ARG37
F	ILE38
F	ALA42
F	VAL43
F	THR44
F	ARG133
F	GLU135
F	PHE167
F	SER168
F	ASN169
F	MG1292
F	THR17
F	GLY18
F	SER19
F	GLY20
F	LYS21
F	SER22
F	ALA23

---

site_id	BC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP C 1295

Chain	Residue
C	THR17
C	GLY18
C	SER19
C	GLY20
C	LYS21
C	SER22
C	ALA23
C	SER36
C	ARG37
C	ILE38
C	VAL43
C	THR44
C	GLY66
C	ARG133
C	GLU135
C	PHE167
C	SER168
C	ASN169
C	MG1294

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01057","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PDB","id":"3ZJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Site: {"description":"Important for catalytic activity"}

Chain

Residue

Details

---