3ZJC
Crystal structure of GMPPNP-bound human GIMAP7 L100Q variant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003924 | molecular_function | GTPase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0005811 | cellular_component | lipid droplet |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046039 | biological_process | GTP metabolic process |
B | 0003924 | molecular_function | GTPase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005794 | cellular_component | Golgi apparatus |
B | 0005811 | cellular_component | lipid droplet |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0046039 | biological_process | GTP metabolic process |
C | 0003924 | molecular_function | GTPase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005525 | molecular_function | GTP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005794 | cellular_component | Golgi apparatus |
C | 0005811 | cellular_component | lipid droplet |
C | 0042802 | molecular_function | identical protein binding |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0046039 | biological_process | GTP metabolic process |
D | 0003924 | molecular_function | GTPase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005525 | molecular_function | GTP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005794 | cellular_component | Golgi apparatus |
D | 0005811 | cellular_component | lipid droplet |
D | 0042802 | molecular_function | identical protein binding |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0046039 | biological_process | GTP metabolic process |
E | 0003924 | molecular_function | GTPase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005525 | molecular_function | GTP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005783 | cellular_component | endoplasmic reticulum |
E | 0005794 | cellular_component | Golgi apparatus |
E | 0005811 | cellular_component | lipid droplet |
E | 0042802 | molecular_function | identical protein binding |
E | 0042803 | molecular_function | protein homodimerization activity |
E | 0046039 | biological_process | GTP metabolic process |
F | 0003924 | molecular_function | GTPase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005525 | molecular_function | GTP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005783 | cellular_component | endoplasmic reticulum |
F | 0005794 | cellular_component | Golgi apparatus |
F | 0005811 | cellular_component | lipid droplet |
F | 0042802 | molecular_function | identical protein binding |
F | 0042803 | molecular_function | protein homodimerization activity |
F | 0046039 | biological_process | GTP metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 1294 |
Chain | Residue |
B | SER22 |
B | THR44 |
B | GNP1295 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1296 |
Chain | Residue |
A | SER22 |
A | THR44 |
A | ASP63 |
A | GNP1297 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG C 1294 |
Chain | Residue |
C | GNP1295 |
C | SER22 |
C | THR44 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG D 1300 |
Chain | Residue |
D | SER22 |
D | THR44 |
D | GNP1301 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG F 1292 |
Chain | Residue |
F | SER22 |
F | THR44 |
F | GNP1293 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG E 1298 |
Chain | Residue |
E | SER22 |
E | THR44 |
E | GNP1299 |
site_id | AC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GNP A 1297 |
Chain | Residue |
A | THR17 |
A | GLY18 |
A | SER19 |
A | GLY20 |
A | LYS21 |
A | SER22 |
A | ALA23 |
A | SER36 |
A | ARG37 |
A | ILE38 |
A | VAL43 |
A | THR44 |
A | ARG133 |
A | GLU135 |
A | PHE167 |
A | SER168 |
A | ASN169 |
A | MG1296 |
B | ARG103 |
site_id | AC8 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GNP B 1295 |
Chain | Residue |
B | GLY18 |
B | SER19 |
B | GLY20 |
B | LYS21 |
B | SER22 |
B | ALA23 |
B | SER36 |
B | ARG37 |
B | ILE38 |
B | ALA42 |
B | VAL43 |
B | THR44 |
B | ARG133 |
B | GLU135 |
B | PHE167 |
B | SER168 |
B | ASN169 |
B | MG1294 |
site_id | AC9 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GNP E 1299 |
Chain | Residue |
E | THR17 |
E | GLY18 |
E | SER19 |
E | GLY20 |
E | LYS21 |
E | SER22 |
E | ALA23 |
E | SER36 |
E | ARG37 |
E | ILE38 |
E | VAL43 |
E | THR44 |
E | THR132 |
E | ARG133 |
E | GLU135 |
E | PHE167 |
E | ASN169 |
E | MG1298 |
site_id | BC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE GNP D 1301 |
Chain | Residue |
D | THR17 |
D | GLY18 |
D | SER19 |
D | GLY20 |
D | LYS21 |
D | SER22 |
D | ALA23 |
D | SER36 |
D | ARG37 |
D | ILE38 |
D | VAL43 |
D | THR44 |
D | THR132 |
D | ARG133 |
D | GLU135 |
D | PHE167 |
D | ASN169 |
D | MG1300 |
site_id | BC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GNP F 1293 |
Chain | Residue |
F | SER36 |
F | ARG37 |
F | ILE38 |
F | ALA42 |
F | VAL43 |
F | THR44 |
F | ARG133 |
F | GLU135 |
F | PHE167 |
F | SER168 |
F | ASN169 |
F | MG1292 |
F | THR17 |
F | GLY18 |
F | SER19 |
F | GLY20 |
F | LYS21 |
F | SER22 |
F | ALA23 |
site_id | BC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE GNP C 1295 |
Chain | Residue |
C | THR17 |
C | GLY18 |
C | SER19 |
C | GLY20 |
C | LYS21 |
C | SER22 |
C | ALA23 |
C | SER36 |
C | ARG37 |
C | ILE38 |
C | VAL43 |
C | THR44 |
C | GLY66 |
C | ARG133 |
C | GLU135 |
C | PHE167 |
C | SER168 |
C | ASN169 |
C | MG1294 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0007744|PDB:3ZJC |
Chain | Residue | Details |
A | THR17 | |
C | ARG37 | |
C | ARG133 | |
C | ASN169 | |
D | THR17 | |
D | ARG37 | |
D | ARG133 | |
D | ASN169 | |
E | THR17 | |
E | ARG37 | |
E | ARG133 | |
A | ARG37 | |
E | ASN169 | |
F | THR17 | |
F | ARG37 | |
F | ARG133 | |
F | ASN169 | |
A | ARG133 | |
A | ASN169 | |
B | THR17 | |
B | ARG37 | |
B | ARG133 | |
B | ASN169 | |
C | THR17 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | SITE: Important for catalytic activity |
Chain | Residue | Details |
A | ARG103 | |
B | ARG103 | |
C | ARG103 | |
D | ARG103 | |
E | ARG103 | |
F | ARG103 |