3ZJC
Crystal structure of GMPPNP-bound human GIMAP7 L100Q variant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046039 | biological_process | GTP metabolic process |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046039 | biological_process | GTP metabolic process |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005811 | cellular_component | lipid droplet |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046039 | biological_process | GTP metabolic process |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005811 | cellular_component | lipid droplet |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046039 | biological_process | GTP metabolic process |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005783 | cellular_component | endoplasmic reticulum |
| E | 0005794 | cellular_component | Golgi apparatus |
| E | 0005811 | cellular_component | lipid droplet |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0046039 | biological_process | GTP metabolic process |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005525 | molecular_function | GTP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005794 | cellular_component | Golgi apparatus |
| F | 0005811 | cellular_component | lipid droplet |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0046039 | biological_process | GTP metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1294 |
| Chain | Residue |
| B | SER22 |
| B | THR44 |
| B | GNP1295 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1296 |
| Chain | Residue |
| A | SER22 |
| A | THR44 |
| A | ASP63 |
| A | GNP1297 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1294 |
| Chain | Residue |
| C | GNP1295 |
| C | SER22 |
| C | THR44 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 1300 |
| Chain | Residue |
| D | SER22 |
| D | THR44 |
| D | GNP1301 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG F 1292 |
| Chain | Residue |
| F | SER22 |
| F | THR44 |
| F | GNP1293 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG E 1298 |
| Chain | Residue |
| E | SER22 |
| E | THR44 |
| E | GNP1299 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GNP A 1297 |
| Chain | Residue |
| A | THR17 |
| A | GLY18 |
| A | SER19 |
| A | GLY20 |
| A | LYS21 |
| A | SER22 |
| A | ALA23 |
| A | SER36 |
| A | ARG37 |
| A | ILE38 |
| A | VAL43 |
| A | THR44 |
| A | ARG133 |
| A | GLU135 |
| A | PHE167 |
| A | SER168 |
| A | ASN169 |
| A | MG1296 |
| B | ARG103 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GNP B 1295 |
| Chain | Residue |
| B | GLY18 |
| B | SER19 |
| B | GLY20 |
| B | LYS21 |
| B | SER22 |
| B | ALA23 |
| B | SER36 |
| B | ARG37 |
| B | ILE38 |
| B | ALA42 |
| B | VAL43 |
| B | THR44 |
| B | ARG133 |
| B | GLU135 |
| B | PHE167 |
| B | SER168 |
| B | ASN169 |
| B | MG1294 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GNP E 1299 |
| Chain | Residue |
| E | THR17 |
| E | GLY18 |
| E | SER19 |
| E | GLY20 |
| E | LYS21 |
| E | SER22 |
| E | ALA23 |
| E | SER36 |
| E | ARG37 |
| E | ILE38 |
| E | VAL43 |
| E | THR44 |
| E | THR132 |
| E | ARG133 |
| E | GLU135 |
| E | PHE167 |
| E | ASN169 |
| E | MG1298 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GNP D 1301 |
| Chain | Residue |
| D | THR17 |
| D | GLY18 |
| D | SER19 |
| D | GLY20 |
| D | LYS21 |
| D | SER22 |
| D | ALA23 |
| D | SER36 |
| D | ARG37 |
| D | ILE38 |
| D | VAL43 |
| D | THR44 |
| D | THR132 |
| D | ARG133 |
| D | GLU135 |
| D | PHE167 |
| D | ASN169 |
| D | MG1300 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GNP F 1293 |
| Chain | Residue |
| F | SER36 |
| F | ARG37 |
| F | ILE38 |
| F | ALA42 |
| F | VAL43 |
| F | THR44 |
| F | ARG133 |
| F | GLU135 |
| F | PHE167 |
| F | SER168 |
| F | ASN169 |
| F | MG1292 |
| F | THR17 |
| F | GLY18 |
| F | SER19 |
| F | GLY20 |
| F | LYS21 |
| F | SER22 |
| F | ALA23 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GNP C 1295 |
| Chain | Residue |
| C | THR17 |
| C | GLY18 |
| C | SER19 |
| C | GLY20 |
| C | LYS21 |
| C | SER22 |
| C | ALA23 |
| C | SER36 |
| C | ARG37 |
| C | ILE38 |
| C | VAL43 |
| C | THR44 |
| C | GLY66 |
| C | ARG133 |
| C | GLU135 |
| C | PHE167 |
| C | SER168 |
| C | ASN169 |
| C | MG1294 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3ZJC |
| Chain | Residue | Details |
| A | THR17 | |
| C | ARG37 | |
| C | ARG133 | |
| C | ASN169 | |
| D | THR17 | |
| D | ARG37 | |
| D | ARG133 | |
| D | ASN169 | |
| E | THR17 | |
| E | ARG37 | |
| E | ARG133 | |
| A | ARG37 | |
| E | ASN169 | |
| F | THR17 | |
| F | ARG37 | |
| F | ARG133 | |
| F | ASN169 | |
| A | ARG133 | |
| A | ASN169 | |
| B | THR17 | |
| B | ARG37 | |
| B | ARG133 | |
| B | ASN169 | |
| C | THR17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | ARG103 | |
| B | ARG103 | |
| C | ARG103 | |
| D | ARG103 | |
| E | ARG103 | |
| F | ARG103 |
