Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ZIA

The structure of F1-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016887	molecular_function	ATP hydrolysis activity
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042645	cellular_component	mitochondrial nucleoid
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016887	molecular_function	ATP hydrolysis activity
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042645	cellular_component	mitochondrial nucleoid
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016887	molecular_function	ATP hydrolysis activity
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042645	cellular_component	mitochondrial nucleoid
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016887	molecular_function	ATP hydrolysis activity
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0032780	biological_process	negative regulation of ATP-dependent activity
J	0042030	molecular_function	ATPase inhibitor activity
K	0000166	molecular_function	nucleotide binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0006754	biological_process	ATP biosynthetic process
K	0006811	biological_process	monoatomic ion transport
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016887	molecular_function	ATP hydrolysis activity
K	0032559	molecular_function	adenyl ribonucleotide binding
K	0042645	cellular_component	mitochondrial nucleoid
K	0043531	molecular_function	ADP binding
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0046034	biological_process	ATP metabolic process
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016887	molecular_function	ATP hydrolysis activity
L	0032559	molecular_function	adenyl ribonucleotide binding
L	0042645	cellular_component	mitochondrial nucleoid
L	0043531	molecular_function	ADP binding
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0046034	biological_process	ATP metabolic process
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000166	molecular_function	nucleotide binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005829	cellular_component	cytosol
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016887	molecular_function	ATP hydrolysis activity
M	0032559	molecular_function	adenyl ribonucleotide binding
M	0042645	cellular_component	mitochondrial nucleoid
M	0043531	molecular_function	ADP binding
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0046034	biological_process	ATP metabolic process
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000166	molecular_function	nucleotide binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0006754	biological_process	ATP biosynthetic process
N	0006811	biological_process	monoatomic ion transport
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016887	molecular_function	ATP hydrolysis activity
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0046034	biological_process	ATP metabolic process
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0006754	biological_process	ATP biosynthetic process
O	0006811	biological_process	monoatomic ion transport
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016887	molecular_function	ATP hydrolysis activity
O	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0046034	biological_process	ATP metabolic process
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0000166	molecular_function	nucleotide binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0006754	biological_process	ATP biosynthetic process
P	0006811	biological_process	monoatomic ion transport
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016887	molecular_function	ATP hydrolysis activity
P	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	0046034	biological_process	ATP metabolic process
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006754	biological_process	ATP biosynthetic process
S	0006811	biological_process	monoatomic ion transport
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016887	molecular_function	ATP hydrolysis activity
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0032780	biological_process	negative regulation of ATP-dependent activity
T	0042030	molecular_function	ATPase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG K 601

Chain	Residue
K	THR178
K	ATP600
K	HOH2013
K	HOH2014
K	HOH2015

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP C 600

Chain	Residue
C	THR178
C	ALA179
C	PHE359
C	ARG364
C	GLN432
C	GLN434
C	MG601
C	HOH2044
C	HOH2093
F	ARG356
C	GLN174
C	THR175
C	GLY176
C	LYS177

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP L 600

Chain	Residue
L	GLN174
L	THR175
L	GLY176
L	LYS177
L	THR178
L	ALA179
L	PHE359
L	ARG364
L	GLN432
L	GLN434
L	MG601
L	HOH2075
L	HOH2156
O	ASP359

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO L 604

Chain	Residue
L	ILE363
L	ILE367
L	THR427

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP O 600

Chain	Residue
O	GLY160
O	VAL161
O	GLY162
O	LYS163
O	THR164
O	VAL165
O	TYR345
O	PHE418
O	ALA421
O	PHE424
O	THR425
O	HOH2052

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO O 602

Chain	Residue
O	ARG231

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP P 600

Chain	Residue
L	ARG375
L	HOH2139
P	GLY160
P	VAL161
P	GLY162
P	LYS163
P	THR164
P	VAL165
P	TYR345
P	PHE418
P	PHE424
P	MG601
P	HOH2030
P	HOH2031
P	HOH2032
P	HOH2035

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG P 601

Chain	Residue
P	THR164
P	ADP600
P	HOH2032
P	HOH2033
P	HOH2034
P	HOH2035

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO P 603

Chain	Residue
P	LYS45
P	VAL47
P	MET64
P	ASP65

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP A 600

Chain	Residue
A	ARG173
A	GLN174
A	THR175
A	GLY176
A	LYS177
A	THR178
A	ALA179
A	PHE359
A	GLN432
A	GLN434
A	MG601
A	HOH2005
A	HOH2006
D	TYR368

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	THR178
A	ATP600
A	HOH2005
A	HOH2006
A	HOH2007

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP B 600

Chain	Residue
B	ALA179
B	PHE359
B	ARG364
B	GLN432
B	GLN434
B	MG601
B	HOH2046
B	HOH2089
B	HOH2090
E	ASP359
B	GLN174
B	THR175
B	GLY176
B	LYS177
B	THR178

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	THR178
B	ADP600
B	HOH2045
B	HOH2046
B	HOH2047
B	HOH2090

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 601

Chain	Residue
C	THR178
C	ADP600
C	HOH2044
C	HOH2045
C	HOH2046
C	HOH2093

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 603

Chain	Residue
C	TYR246
C	TYR280
C	ASP299
C	TYR302
C	LEU303
C	ARG306

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP D 600

Chain	Residue
C	ARG375
C	HOH2088
C	HOH2090
D	GLY158
D	GLY160
D	VAL161
D	GLY162
D	LYS163
D	THR164
D	VAL165
D	TYR345
D	ALA421
D	PHE424
D	MG601
D	HOH2021

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 601

Chain	Residue
C	HOH2090
D	THR164
D	ADP600
D	HOH2018
D	HOH2019
D	HOH2021

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP E 600

Chain	Residue
E	GLY160
E	VAL161
E	GLY162
E	LYS163
E	THR164
E	VAL165
E	TYR345
E	PHE418
E	ALA421
E	PHE424
E	THR425
E	HOH2008

site_id	CC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP F 600

Chain	Residue
B	ARG375
B	HOH2084
F	GLY160
F	VAL161
F	GLY162
F	LYS163
F	THR164
F	VAL165
F	TYR345
F	PHE418
F	PHE424
F	MG601
F	HOH2041
F	HOH2042
F	HOH2044
F	HOH2047

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 601

Chain	Residue
F	THR164
F	ADP600
F	HOH2043
F	HOH2044
F	HOH2045
F	HOH2047

site_id	CC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP K 600

Chain	Residue
K	ARG173
K	GLN174
K	THR175
K	GLY176
K	LYS177
K	THR178
K	ALA179
K	PHE359
K	GLN432
K	GLN434
K	MG601
K	HOH2011
K	HOH2012
K	HOH2013
K	HOH2015
N	TYR368

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG L 601

Chain	Residue
L	THR178
L	ADP600
L	HOH2075
L	HOH2076
L	HOH2077
L	HOH2156

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO L 602

Chain	Residue
L	ARG293
L	HOH2121
P	VAL279
P	HOH2053

site_id	CC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP M 600

Chain	Residue
M	GLN174
M	THR175
M	GLY176
M	LYS177
M	THR178
M	ALA179
M	PHE359
M	ARG364
M	GLN432
M	GLN434
M	MG601
M	HOH2031
M	HOH2076
P	ARG356

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG M 601

Chain	Residue
M	THR178
M	ADP600
M	HOH2031
M	HOH2032
M	HOH2033
M	HOH2076

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO M 602

Chain	Residue
M	TYR246
M	TYR280
M	ASP299
M	TYR302
M	LEU303
M	ARG306

site_id	CC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP N 600

Chain	Residue
M	ARG375
M	HOH2070
N	GLY158
N	GLY160
N	VAL161
N	GLY162
N	LYS163
N	THR164
N	VAL165
N	TYR345
N	ALA421
N	PHE424
N	MG601
N	HOH2019

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG N 601

Chain	Residue
M	HOH2070
N	THR164
N	ADP600
N	HOH2016
N	HOH2017
N	HOH2019

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSKS

Chain	Residue	Details
D	PRO346-SER355
A	PRO365-SER374

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITnElvDiitGAsS

Chain	Residue	Details
G	ILE263-SER276

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Required for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)