3ZHH

X-ray structure of the full-length beta-lactamase from M.tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1292

Chain	Residue
A	SER70
A	SER130
A	THR235
A	THR237
A	HOH2027
B	GLN110
B	GLN111

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1293

Chain	Residue
A	ARG213
A	ASP124
A	ARG128

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1294

Chain	Residue
A	ASN170
A	ARG171
A	ASP239
A	TYR270
B	SER99
B	GLN114

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1295

Chain	Residue
A	THR149
A	ARG153
A	THR158
A	VAL159
A	SER160
A	ARG161

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1296

Chain	Residue
A	ASP202
A	LYS203

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1292

Chain	Residue
B	SER70
B	SER130
B	THR216
B	THR235
B	GLY236
B	THR237
B	HOH2008

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1293

Chain	Residue
B	ASP124
B	ARG128
B	ARG213

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1294

Chain	Residue
B	ARG275
B	GLU276
B	ALA277

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 1295

Chain	Residue
B	THR54

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1292

Chain	Residue
C	SER70
C	SER130
C	THR235
C	GLY236
C	THR237
C	HOH2022

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1293

Chain	Residue
C	ASP124
C	ARG128
C	ARG213

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1294

Chain	Residue
C	PRO167
C	ASN170
C	ARG171
C	ASP239
C	TYR270

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1292

Chain	Residue
D	SER70
D	SER130
D	THR235
D	GLY236
D	THR237
D	HOH2008

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1293

Chain	Residue
D	ASP124
D	ARG128
D	ARG213

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 1294

Chain	Residue
D	GLU64

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1295

Chain	Residue
A	ARG40
A	GLU281
D	SER251
D	PRO252
D	THR253
D	HOH2022

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1296

Chain	Residue
D	ALA212
D	ASN214
D	ARG222
D	VAL231
D	ASP233

---

Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL

Chain	Residue	Details
A	PHE66-LEU81

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19251630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Increases nucleophilicity of active site Ser","evidences":[{"source":"PubMed","id":"20353175","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"20961112","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site","evidences":[{"source":"PubMed","id":"24023821","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---