3ZG6
The novel de-long chain fatty acid function of human sirt6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1295 |
| Chain | Residue |
| A | CYS139 |
| A | CYS142 |
| A | CYS164 |
| A | CYS175 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE APR A 1296 |
| Chain | Residue |
| A | PHE62 |
| A | ARG63 |
| A | TRP69 |
| A | GLN111 |
| A | HIS131 |
| A | GLY212 |
| A | THR213 |
| A | SER214 |
| A | ILE217 |
| A | ASN238 |
| A | LEU239 |
| A | GLN240 |
| A | GLY254 |
| A | TYR255 |
| A | VAL256 |
| A | GOL1299 |
| A | HOH2019 |
| A | HOH2033 |
| A | HOH2041 |
| A | HOH2061 |
| A | HOH2145 |
| A | HOH2146 |
| A | GLY50 |
| A | ALA51 |
| A | GLY52 |
| A | THR55 |
| A | ASP61 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1298 |
| Chain | Residue |
| A | GLU187 |
| A | HIS244 |
| A | ARG246 |
| A | HIS247 |
| F | TRP15 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1299 |
| Chain | Residue |
| A | GLU20 |
| A | THR55 |
| A | ASP61 |
| A | PRO65 |
| A | APR1296 |
| A | HOH2018 |
| A | HOH2019 |
| A | HOH2040 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| F | LYS4 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| F | GLN5 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| F | THR6 | |
| A | GLN240 | |
| A | VAL256 | |
| A | PHE62 | |
| A | ARG63 | |
| A | TRP69 | |
| A | GLN111 | |
| A | HIS131 | |
| A | GLY212 | |
| A | SER214 | |
| A | ASN238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| F | ARG8 | |
| A | CYS142 | |
| A | CYS164 | |
| A | CYS175 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| F | MYK9 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| F | SER10 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| F | THR11 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:32538779 |
| Chain | Residue | Details |
| A | LYS31 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR292 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24043303 |
| Chain | Residue | Details |
| A | LYS168 |
