3ZBV
Crystal Structure of murine Angiogenin-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001934 | biological_process | positive regulation of protein phosphorylation |
| A | 0003300 | biological_process | cardiac muscle hypertrophy |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0010467 | biological_process | gene expression |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0038166 | biological_process | angiotensin-activated signaling pathway |
| A | 0045087 | biological_process | innate immune response |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061049 | biological_process | cell growth involved in cardiac muscle cell development |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 0070293 | biological_process | renal absorption |
| A | 0070528 | biological_process | protein kinase C signaling |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1121 |
| Chain | Residue |
| A | ASP41 |
| A | HIS82 |
| A | HIS113 |
| A | HOH2126 |
| A | HOH2128 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1122 |
| Chain | Residue |
| A | ASP41 |
| A | ASP41 |
| A | VAL42 |
| A | VAL42 |
| A | PHE38 |
| A | PHE38 |
| A | LYS40 |
| A | LYS40 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1123 |
| Chain | Residue |
| A | ASN67 |
| A | GLY84 |
| A | ARG85 |
| A | SER86 |
| A | ARG92 |
| A | HOH2102 |
| A | HOH2105 |
| A | HOH2109 |
| A | HOH2111 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1124 |
| Chain | Residue |
| A | TYR14 |
| A | THR49 |
| A | LYS50 |
| A | ASN51 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdvNTF |
| Chain | Residue | Details |
| A | CYS39-PHE45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:23170778 |
| Chain | Residue | Details |
| A | HIS13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:23170778 |
| Chain | Residue | Details |
| A | HIS113 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS8 | |
| A | LYS40 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS82 | |
| A | HIS113 | |
| A | ASP41 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Critical for catalytic activity => ECO:0000305|PubMed:23170778 |
| Chain | Residue | Details |
| A | LYS40 |
