Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004013 | molecular_function | adenosylhomocysteinase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0033353 | biological_process | S-adenosylmethionine cycle |
A | 0071269 | biological_process | L-homocysteine biosynthetic process |
B | 0004013 | molecular_function | adenosylhomocysteinase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0033353 | biological_process | S-adenosylmethionine cycle |
B | 0071269 | biological_process | L-homocysteine biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAI A 501 |
Chain | Residue |
A | THR142 |
A | GLU227 |
A | VAL228 |
A | ASP229 |
A | LYS232 |
A | ALA259 |
A | SER260 |
A | GLY261 |
A | ASN262 |
A | ALA283 |
A | GLY284 |
A | THR143 |
A | HIS285 |
A | LEU328 |
A | ASN330 |
A | HIS337 |
A | NO3507 |
A | NO3508 |
A | HOH650 |
A | HOH653 |
A | HOH773 |
A | HOH842 |
A | ASP174 |
B | GLN397 |
A | THR179 |
A | GLY204 |
A | GLY206 |
A | TRP207 |
A | CYS208 |
A | THR226 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 502 |
Chain | Residue |
A | GLN72 |
A | GLN72 |
A | ASP74 |
A | ASP74 |
A | GLU77 |
A | GLU77 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 503 |
Chain | Residue |
A | ASP384 |
A | HOH682 |
A | HOH683 |
A | HOH684 |
A | HOH686 |
B | GLU132 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO3 A 504 |
Chain | Residue |
A | ILE52 |
A | SER55 |
A | LYS56 |
A | HOH605 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 A 505 |
Chain | Residue |
A | SER70 |
A | THR71 |
A | ASP73 |
A | ALA76 |
A | ARG80 |
A | ARG90 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NO3 A 506 |
Chain | Residue |
A | SER66 |
A | ASN67 |
A | ARG89 |
A | HIS92 |
A | ARG327 |
A | HOH647 |
A | HOH648 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 507 |
Chain | Residue |
A | THR141 |
A | HIS285 |
A | LEU328 |
A | NAI501 |
A | NO3508 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 A 508 |
Chain | Residue |
A | THR141 |
A | THR142 |
A | ASN165 |
A | PHE173 |
A | NAI501 |
A | NO3507 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 A 509 |
Chain | Residue |
A | ARG377 |
A | ARG380 |
A | HOH694 |
A | HOH695 |
B | LEU131 |
B | ARG158 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 510 |
Chain | Residue |
A | GLU376 |
A | ARG380 |
A | HOH689 |
A | HOH690 |
B | GLU128 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 511 |
Chain | Residue |
A | ARG398 |
B | GLU126 |
B | ARG127 |
B | GLU128 |
B | GLU129 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NO3 A 512 |
Chain | Residue |
A | LYS21 |
A | ASP384 |
A | SER385 |
A | HOH752 |
A | HOH785 |
A | HOH786 |
B | ARG361 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE NO3 A 513 |
Chain | Residue |
A | HOH762 |
A | HOH919 |
A | HIS42 |
A | GLU44 |
A | LYS46 |
A | LEU331 |
A | ASP335 |
A | GLY336 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 514 |
Chain | Residue |
A | ASN199 |
A | ILE252 |
A | LYS275 |
A | HOH797 |
A | HOH798 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 A 515 |
Chain | Residue |
A | PHE35 |
A | LYS135 |
A | HIS360 |
A | ARG361 |
A | NO3521 |
A | HOH868 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 516 |
Chain | Residue |
A | GLU358 |
A | ASN359 |
A | HIS360 |
A | ARG361 |
A | LYS362 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NO3 A 517 |
Chain | Residue |
A | SER403 |
A | TRP404 |
A | GLN405 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 518 |
Chain | Residue |
A | ILE9 |
A | ILE52 |
A | LYS56 |
A | LYS82 |
A | HOH631 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NO3 A 519 |
Chain | Residue |
A | ASN10 |
A | ARG14 |
B | HOH631 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 A 520 |
Chain | Residue |
A | GLU24 |
A | SER27 |
A | ARG28 |
A | HOH863 |
B | LYS362 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO3 A 521 |
Chain | Residue |
A | HIS360 |
A | ARG361 |
A | NO3515 |
A | HOH886 |
site_id | CC4 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAI B 501 |
Chain | Residue |
A | GLN397 |
B | THR141 |
B | THR142 |
B | THR143 |
B | ASP174 |
B | THR179 |
B | GLY204 |
B | GLY206 |
B | TRP207 |
B | CYS208 |
B | THR226 |
B | GLU227 |
B | VAL228 |
B | ASP229 |
B | LYS232 |
B | ALA259 |
B | SER260 |
B | GLY261 |
B | ASN262 |
B | ALA283 |
B | GLY284 |
B | HIS285 |
B | LEU328 |
B | ASN330 |
B | HIS337 |
B | NO3509 |
B | NO3510 |
B | HOH610 |
B | HOH651 |
B | HOH653 |
B | HOH713 |
B | HOH714 |
B | HOH716 |
B | HOH806 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B 502 |
Chain | Residue |
B | PRO160 |
B | HIS360 |
B | MET363 |
B | NO3523 |
B | HOH842 |
B | HOH844 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 503 |
Chain | Residue |
B | PRO291 |
B | VAL292 |
B | ARG293 |
B | VAL294 |
B | HOH643 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO3 B 504 |
Chain | Residue |
B | ASN199 |
B | ILE252 |
B | LYS275 |
B | HOH677 |
site_id | CC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 505 |
Chain | Residue |
B | PHE35 |
B | LYS135 |
B | LEU357 |
B | HIS360 |
B | ARG361 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 B 506 |
Chain | Residue |
B | GLU358 |
B | ASN359 |
B | HIS360 |
B | ARG361 |
B | LYS362 |
B | HOH911 |
site_id | DC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 507 |
Chain | Residue |
B | PHE351 |
B | ILE374 |
B | ARG377 |
B | HOH700 |
B | HOH863 |
site_id | DC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NO3 B 508 |
Chain | Residue |
B | TYR368 |
B | MET369 |
site_id | DC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NO3 B 509 |
Chain | Residue |
B | ASP115 |
B | THR141 |
B | HIS285 |
B | LEU328 |
B | NAI501 |
B | NO3510 |
site_id | DC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE NO3 B 510 |
Chain | Residue |
B | GLU140 |
B | THR141 |
B | THR142 |
B | ASN165 |
B | PHE173 |
B | NAI501 |
B | NO3509 |
B | HOH612 |
B | HOH806 |
site_id | DC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE NO3 B 511 |
Chain | Residue |
A | LYS8 |
A | TRP11 |
A | VAL12 |
A | ALA45 |
A | LYS46 |
A | VAL339 |
A | HOH717 |
B | ASN192 |
B | ARG306 |
B | HOH845 |
site_id | DC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NO3 B 512 |
Chain | Residue |
B | SER55 |
B | ALA59 |
B | LYS60 |
B | VAL61 |
B | GLY83 |
B | ILE84 |
B | HOH937 |
site_id | DC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NO3 B 513 |
Chain | Residue |
B | ASN3 |
B | GLY5 |
B | GLU6 |
B | ASP74 |
B | GLU77 |
B | ALA78 |
B | HOH840 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 514 |
Chain | Residue |
B | PRO17 |
B | LYS382 |
B | SER385 |
B | LEU386 |
B | HOH852 |
site_id | DC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 515 |
Chain | Residue |
B | ILE9 |
B | TYR49 |
B | ILE52 |
B | LYS56 |
B | LYS82 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 516 |
Chain | Residue |
A | PHE303 |
A | PHE321 |
B | ARG14 |
B | HOH745 |
B | HOH857 |
site_id | EC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 517 |
Chain | Residue |
A | LYS103 |
B | GLN72 |
B | ASP73 |
B | ARG90 |
B | HOH729 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NO3 B 518 |
Chain | Residue |
B | MET102 |
B | GLU126 |
B | ARG127 |
B | HOH734 |
site_id | EC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 519 |
Chain | Residue |
B | HIS285 |
B | PHE286 |
B | ASN287 |
B | HOH618 |
B | HOH726 |
site_id | EC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 520 |
Chain | Residue |
B | GLY34 |
B | PHE35 |
B | THR36 |
B | HOH658 |
B | HOH738 |
site_id | EC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE NO3 B 521 |
Chain | Residue |
A | LYS389 |
A | GLU392 |
B | ASP106 |
B | GLU107 |
B | ARG108 |
B | HOH655 |
B | HOH656 |
B | HOH791 |
B | HOH919 |
site_id | EC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 522 |
Chain | Residue |
B | ARG189 |
B | ASN190 |
B | ASN308 |
B | ALA333 |
B | GLY334 |
site_id | EC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE NO3 B 523 |
Chain | Residue |
A | HOH694 |
B | LEU134 |
B | LYS135 |
B | ARG158 |
B | VAL159 |
B | PRO160 |
B | HIS360 |
B | NA502 |
B | HOH843 |
B | HOH844 |
site_id | EC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NO3 B 524 |
Chain | Residue |
B | LEU69 |
B | SER70 |
B | ARG90 |
B | ARG327 |
B | ALA332 |
Functional Information from PROSITE/UniProt
site_id | PS00738 |
Number of Residues | 15 |
Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. GSNpLSTQDdVAEAL |
Chain | Residue | Details |
A | GLY65-LEU79 | |
site_id | PS00739 |
Number of Residues | 17 |
Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKnvvVaGYGwCGRGi.A |
Chain | Residue | Details |
A | GLY197-ALA213 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP115 | |
A | ALA283 | |
A | ASN330 | |
B | ASP115 | |
B | GLU140 | |
B | THR141 | |
B | LYS170 | |
B | ASP174 | |
B | ASN175 | |
B | GLY204 | |
B | GLU227 | |
A | GLU140 | |
B | ASN262 | |
B | ALA283 | |
B | ASN330 | |
A | THR141 | |
A | LYS170 | |
A | ASP174 | |
A | ASN175 | |
A | GLY204 | |
A | GLU227 | |
A | ASN262 | |