Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004013 | molecular_function | adenosylhomocysteinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0071269 | biological_process | L-homocysteine biosynthetic process |
| B | 0004013 | molecular_function | adenosylhomocysteinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033353 | biological_process | S-adenosylmethionine cycle |
| B | 0071269 | biological_process | L-homocysteine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAI A 501 |
| Chain | Residue |
| A | THR142 |
| A | GLU227 |
| A | VAL228 |
| A | ASP229 |
| A | LYS232 |
| A | ALA259 |
| A | SER260 |
| A | GLY261 |
| A | ASN262 |
| A | ALA283 |
| A | GLY284 |
| A | THR143 |
| A | HIS285 |
| A | LEU328 |
| A | ASN330 |
| A | HIS337 |
| A | NO3507 |
| A | NO3508 |
| A | HOH650 |
| A | HOH653 |
| A | HOH773 |
| A | HOH842 |
| A | ASP174 |
| B | GLN397 |
| A | THR179 |
| A | GLY204 |
| A | GLY206 |
| A | TRP207 |
| A | CYS208 |
| A | THR226 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | GLN72 |
| A | GLN72 |
| A | ASP74 |
| A | ASP74 |
| A | GLU77 |
| A | GLU77 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 503 |
| Chain | Residue |
| A | ASP384 |
| A | HOH682 |
| A | HOH683 |
| A | HOH684 |
| A | HOH686 |
| B | GLU132 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 A 504 |
| Chain | Residue |
| A | ILE52 |
| A | SER55 |
| A | LYS56 |
| A | HOH605 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 505 |
| Chain | Residue |
| A | SER70 |
| A | THR71 |
| A | ASP73 |
| A | ALA76 |
| A | ARG80 |
| A | ARG90 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 A 506 |
| Chain | Residue |
| A | SER66 |
| A | ASN67 |
| A | ARG89 |
| A | HIS92 |
| A | ARG327 |
| A | HOH647 |
| A | HOH648 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 507 |
| Chain | Residue |
| A | THR141 |
| A | HIS285 |
| A | LEU328 |
| A | NAI501 |
| A | NO3508 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 508 |
| Chain | Residue |
| A | THR141 |
| A | THR142 |
| A | ASN165 |
| A | PHE173 |
| A | NAI501 |
| A | NO3507 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 509 |
| Chain | Residue |
| A | ARG377 |
| A | ARG380 |
| A | HOH694 |
| A | HOH695 |
| B | LEU131 |
| B | ARG158 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 510 |
| Chain | Residue |
| A | GLU376 |
| A | ARG380 |
| A | HOH689 |
| A | HOH690 |
| B | GLU128 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 511 |
| Chain | Residue |
| A | ARG398 |
| B | GLU126 |
| B | ARG127 |
| B | GLU128 |
| B | GLU129 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 A 512 |
| Chain | Residue |
| A | LYS21 |
| A | ASP384 |
| A | SER385 |
| A | HOH752 |
| A | HOH785 |
| A | HOH786 |
| B | ARG361 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 A 513 |
| Chain | Residue |
| A | HOH762 |
| A | HOH919 |
| A | HIS42 |
| A | GLU44 |
| A | LYS46 |
| A | LEU331 |
| A | ASP335 |
| A | GLY336 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 514 |
| Chain | Residue |
| A | ASN199 |
| A | ILE252 |
| A | LYS275 |
| A | HOH797 |
| A | HOH798 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 515 |
| Chain | Residue |
| A | PHE35 |
| A | LYS135 |
| A | HIS360 |
| A | ARG361 |
| A | NO3521 |
| A | HOH868 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 516 |
| Chain | Residue |
| A | GLU358 |
| A | ASN359 |
| A | HIS360 |
| A | ARG361 |
| A | LYS362 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NO3 A 517 |
| Chain | Residue |
| A | SER403 |
| A | TRP404 |
| A | GLN405 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 518 |
| Chain | Residue |
| A | ILE9 |
| A | ILE52 |
| A | LYS56 |
| A | LYS82 |
| A | HOH631 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NO3 A 519 |
| Chain | Residue |
| A | ASN10 |
| A | ARG14 |
| B | HOH631 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 520 |
| Chain | Residue |
| A | GLU24 |
| A | SER27 |
| A | ARG28 |
| A | HOH863 |
| B | LYS362 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 A 521 |
| Chain | Residue |
| A | HIS360 |
| A | ARG361 |
| A | NO3515 |
| A | HOH886 |
| site_id | CC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAI B 501 |
| Chain | Residue |
| A | GLN397 |
| B | THR141 |
| B | THR142 |
| B | THR143 |
| B | ASP174 |
| B | THR179 |
| B | GLY204 |
| B | GLY206 |
| B | TRP207 |
| B | CYS208 |
| B | THR226 |
| B | GLU227 |
| B | VAL228 |
| B | ASP229 |
| B | LYS232 |
| B | ALA259 |
| B | SER260 |
| B | GLY261 |
| B | ASN262 |
| B | ALA283 |
| B | GLY284 |
| B | HIS285 |
| B | LEU328 |
| B | ASN330 |
| B | HIS337 |
| B | NO3509 |
| B | NO3510 |
| B | HOH610 |
| B | HOH651 |
| B | HOH653 |
| B | HOH713 |
| B | HOH714 |
| B | HOH716 |
| B | HOH806 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 502 |
| Chain | Residue |
| B | PRO160 |
| B | HIS360 |
| B | MET363 |
| B | NO3523 |
| B | HOH842 |
| B | HOH844 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 503 |
| Chain | Residue |
| B | PRO291 |
| B | VAL292 |
| B | ARG293 |
| B | VAL294 |
| B | HOH643 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 504 |
| Chain | Residue |
| B | ASN199 |
| B | ILE252 |
| B | LYS275 |
| B | HOH677 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 505 |
| Chain | Residue |
| B | PHE35 |
| B | LYS135 |
| B | LEU357 |
| B | HIS360 |
| B | ARG361 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 B 506 |
| Chain | Residue |
| B | GLU358 |
| B | ASN359 |
| B | HIS360 |
| B | ARG361 |
| B | LYS362 |
| B | HOH911 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 507 |
| Chain | Residue |
| B | PHE351 |
| B | ILE374 |
| B | ARG377 |
| B | HOH700 |
| B | HOH863 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NO3 B 508 |
| Chain | Residue |
| B | TYR368 |
| B | MET369 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 B 509 |
| Chain | Residue |
| B | ASP115 |
| B | THR141 |
| B | HIS285 |
| B | LEU328 |
| B | NAI501 |
| B | NO3510 |
| site_id | DC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NO3 B 510 |
| Chain | Residue |
| B | GLU140 |
| B | THR141 |
| B | THR142 |
| B | ASN165 |
| B | PHE173 |
| B | NAI501 |
| B | NO3509 |
| B | HOH612 |
| B | HOH806 |
| site_id | DC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NO3 B 511 |
| Chain | Residue |
| A | LYS8 |
| A | TRP11 |
| A | VAL12 |
| A | ALA45 |
| A | LYS46 |
| A | VAL339 |
| A | HOH717 |
| B | ASN192 |
| B | ARG306 |
| B | HOH845 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B 512 |
| Chain | Residue |
| B | SER55 |
| B | ALA59 |
| B | LYS60 |
| B | VAL61 |
| B | GLY83 |
| B | ILE84 |
| B | HOH937 |
| site_id | DC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B 513 |
| Chain | Residue |
| B | ASN3 |
| B | GLY5 |
| B | GLU6 |
| B | ASP74 |
| B | GLU77 |
| B | ALA78 |
| B | HOH840 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 514 |
| Chain | Residue |
| B | PRO17 |
| B | LYS382 |
| B | SER385 |
| B | LEU386 |
| B | HOH852 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 515 |
| Chain | Residue |
| B | ILE9 |
| B | TYR49 |
| B | ILE52 |
| B | LYS56 |
| B | LYS82 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 516 |
| Chain | Residue |
| A | PHE303 |
| A | PHE321 |
| B | ARG14 |
| B | HOH745 |
| B | HOH857 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 517 |
| Chain | Residue |
| A | LYS103 |
| B | GLN72 |
| B | ASP73 |
| B | ARG90 |
| B | HOH729 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 518 |
| Chain | Residue |
| B | MET102 |
| B | GLU126 |
| B | ARG127 |
| B | HOH734 |
| site_id | EC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 519 |
| Chain | Residue |
| B | HIS285 |
| B | PHE286 |
| B | ASN287 |
| B | HOH618 |
| B | HOH726 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 520 |
| Chain | Residue |
| B | GLY34 |
| B | PHE35 |
| B | THR36 |
| B | HOH658 |
| B | HOH738 |
| site_id | EC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NO3 B 521 |
| Chain | Residue |
| A | LYS389 |
| A | GLU392 |
| B | ASP106 |
| B | GLU107 |
| B | ARG108 |
| B | HOH655 |
| B | HOH656 |
| B | HOH791 |
| B | HOH919 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 522 |
| Chain | Residue |
| B | ARG189 |
| B | ASN190 |
| B | ASN308 |
| B | ALA333 |
| B | GLY334 |
| site_id | EC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NO3 B 523 |
| Chain | Residue |
| A | HOH694 |
| B | LEU134 |
| B | LYS135 |
| B | ARG158 |
| B | VAL159 |
| B | PRO160 |
| B | HIS360 |
| B | NA502 |
| B | HOH843 |
| B | HOH844 |
| site_id | EC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 B 524 |
| Chain | Residue |
| B | LEU69 |
| B | SER70 |
| B | ARG90 |
| B | ARG327 |
| B | ALA332 |
Functional Information from PROSITE/UniProt
| site_id | PS00738 |
| Number of Residues | 15 |
| Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. GSNpLSTQDdVAEAL |
| Chain | Residue | Details |
| A | GLY65-LEU79 | |
| site_id | PS00739 |
| Number of Residues | 17 |
| Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKnvvVaGYGwCGRGi.A |
| Chain | Residue | Details |
| A | GLY197-ALA213 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00563","evidenceCode":"ECO:0000255"}]} |
