3X2E
A thermophilic hydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004013 | molecular_function | adenosylhomocysteinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0071269 | biological_process | L-homocysteine biosynthetic process |
| B | 0004013 | molecular_function | adenosylhomocysteinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033353 | biological_process | S-adenosylmethionine cycle |
| B | 0071269 | biological_process | L-homocysteine biosynthetic process |
| C | 0004013 | molecular_function | adenosylhomocysteinase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0033353 | biological_process | S-adenosylmethionine cycle |
| C | 0071269 | biological_process | L-homocysteine biosynthetic process |
| D | 0004013 | molecular_function | adenosylhomocysteinase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0033353 | biological_process | S-adenosylmethionine cycle |
| D | 0071269 | biological_process | L-homocysteine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAI A 500 |
| Chain | Residue |
| A | ASP174 |
| A | ASP229 |
| A | LYS232 |
| A | ALA259 |
| A | SER260 |
| A | GLY261 |
| A | ASN262 |
| A | ALA283 |
| A | GLY284 |
| A | HIS285 |
| A | ASN330 |
| A | ASN175 |
| A | HIS337 |
| B | GLN397 |
| A | THR179 |
| A | GLY204 |
| A | GLY206 |
| A | TRP207 |
| A | CYS208 |
| A | THR226 |
| A | GLU227 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAI B 500 |
| Chain | Residue |
| A | GLN397 |
| B | ASP174 |
| B | ASN175 |
| B | THR179 |
| B | GLY204 |
| B | GLY206 |
| B | TRP207 |
| B | CYS208 |
| B | THR226 |
| B | GLU227 |
| B | ASP229 |
| B | LYS232 |
| B | ALA259 |
| B | SER260 |
| B | GLY261 |
| B | ASN262 |
| B | ALA283 |
| B | GLY284 |
| B | HIS285 |
| B | LEU328 |
| B | ASN330 |
| B | HIS337 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAI C 500 |
| Chain | Residue |
| C | ASP174 |
| C | ASN175 |
| C | GLY204 |
| C | GLY206 |
| C | TRP207 |
| C | CYS208 |
| C | THR226 |
| C | GLU227 |
| C | VAL228 |
| C | ASP229 |
| C | LYS232 |
| C | ALA259 |
| C | SER260 |
| C | GLY261 |
| C | ASN262 |
| C | ALA283 |
| C | GLY284 |
| C | HIS285 |
| C | LEU328 |
| C | ASN330 |
| C | HIS337 |
| D | GLN397 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAI D 500 |
| Chain | Residue |
| C | GLN397 |
| D | ASP174 |
| D | ASN175 |
| D | GLY204 |
| D | GLY206 |
| D | TRP207 |
| D | CYS208 |
| D | THR226 |
| D | GLU227 |
| D | VAL228 |
| D | ASP229 |
| D | LYS232 |
| D | ALA259 |
| D | SER260 |
| D | GLY261 |
| D | ASN262 |
| D | ALA283 |
| D | GLY284 |
| D | HIS285 |
| D | LEU328 |
| D | ASN330 |
| D | HIS337 |
Functional Information from PROSITE/UniProt
| site_id | PS00738 |
| Number of Residues | 15 |
| Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. GSNpLSTQDdVAEAL |
| Chain | Residue | Details |
| A | GLY65-LEU79 |
| site_id | PS00739 |
| Number of Residues | 17 |
| Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKnvvVaGYGwCGRGi.A |
| Chain | Residue | Details |
| A | GLY197-ALA213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00563","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
