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3WYL

Crystal structure of the catalytic domain of PDE10A complexed with 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN A 1001
ChainResidue
AHIS519
AHIS553
AASP554
AASP664
AMG1002
AHOH1107
AHOH1116

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MG A 1002
ChainResidue
AZN1001
AHOH1102
AHOH1103
AHOH1106
AHOH1107
AHOH1108
AASP554
AGLU582

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 3KB A 1003
ChainResidue
ALEU625
ALEU665
ATYR683
APHE686
AGLN716
APHE719
AHOH1109

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN B 1001
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BMG1002
BHOH1104
BHOH1112

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 1002
ChainResidue
BASP554
BZN1001
BHOH1103
BHOH1105
BHOH1110
BHOH1111
BHOH1112

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 3KB B 1003
ChainResidue
ALEU696
AGLY697
BTYR514
BLEU625
BSER667
BTYR683
BGLN716
BPHE719

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AASN562
ASER606
AGLN640
AMET659
BASN562
BSER606
BGLN640
BMET659

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PDB entries from 2024-07-24

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