Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3WYK

Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 1001
ChainResidue
AASP554
AGLU582
AHOH1144
AHOH1149
AHOH1169
AHOH1170
AHOH1171

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 1002
ChainResidue
AASP554
AASP664
AHOH1149
AHOH1168
AHIS519
AHIS553

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 3KG A 1003
ChainResidue
ATYR514
AHIS515
AMET703
AGLN716
APHE719
AHOH1103

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 1001
ChainResidue
BASP554
BHOH1112
BHOH1113
BHOH1163
BHOH1164
BHOH1166

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 1002
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BHOH1162
BHOH1163

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 3KG B 1003
ChainResidue
ALEU696
AGLY697
AILE698
AHOH1107
BTYR514
BGLN716
BPHE719
BHOH1116

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AASN562
ASER606
AGLN640
AMET659
BASN562
BSER606
BGLN640
BMET659

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon