3WYG

Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006913	biological_process	nucleocytoplasmic transport
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000776	cellular_component	kinetochore
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005816	cellular_component	spindle pole body
C	0006406	biological_process	mRNA export from nucleus
C	0006409	biological_process	tRNA export from nucleus
C	0006611	biological_process	protein export from nucleus
C	0006886	biological_process	intracellular protein transport
C	0015031	biological_process	protein transport
C	0017070	molecular_function	U6 snRNA binding
C	0030619	molecular_function	U1 snRNA binding
C	0030620	molecular_function	U2 snRNA binding
C	0030621	molecular_function	U4 snRNA binding
C	0030623	molecular_function	U5 snRNA binding
C	0031267	molecular_function	small GTPase binding
C	0034501	biological_process	protein localization to kinetochore
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051168	biological_process	nuclear export
C	0051170	biological_process	import into nucleus
C	0061608	molecular_function	nuclear import signal receptor activity
C	0071528	biological_process	tRNA re-export from nucleus
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0004860	molecular_function	protein kinase inhibitor activity
D	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006469	biological_process	negative regulation of protein kinase activity
D	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
D	0034236	molecular_function	protein kinase A catalytic subunit binding
D	0042308	biological_process	negative regulation of protein import into nucleus
D	0141162	biological_process	negative regulation of cAMP/PKA signal transduction
D	2000480	biological_process	negative regulation of cAMP-dependent protein kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GTP A 201

Chain	Residue
A	GLY21
A	LYS39
A	LYS40
A	TYR41
A	ALA43
A	THR44
A	GLY70
A	ASN124
A	LYS125
A	ASP127
A	VAL128
A	GLY22
A	SER152
A	ALA153
A	LYS154
A	MG202
A	HOH301
A	HOH303
A	HOH342
A	HOH366
A	HOH421
A	THR23
A	GLY24
A	LYS25
A	THR26
A	THR27
A	PHE37
A	GLU38

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	THR26
A	THR44
A	GTP201
A	HOH303
A	HOH421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62825

Chain	Residue	Details
A	SER152
A	ASP20
A	GLY70
A	ASN124

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377

Chain	Residue	Details
A	SER2

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