Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WXL

Crystal structure of trypanosoma brucei gambiense glycerol kinase complex with adp, mg2+, and glycerol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004370	molecular_function	glycerol kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005975	biological_process	carbohydrate metabolic process
A	0006071	biological_process	glycerol metabolic process
A	0006072	biological_process	glycerol-3-phosphate metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019563	biological_process	glycerol catabolic process
A	0046167	biological_process	glycerol-3-phosphate biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004370	molecular_function	glycerol kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005975	biological_process	carbohydrate metabolic process
B	0006071	biological_process	glycerol metabolic process
B	0006072	biological_process	glycerol-3-phosphate metabolic process
B	0006641	biological_process	triglyceride metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019563	biological_process	glycerol catabolic process
B	0046167	biological_process	glycerol-3-phosphate biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004370	molecular_function	glycerol kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005975	biological_process	carbohydrate metabolic process
C	0006071	biological_process	glycerol metabolic process
C	0006072	biological_process	glycerol-3-phosphate metabolic process
C	0006641	biological_process	triglyceride metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019563	biological_process	glycerol catabolic process
C	0046167	biological_process	glycerol-3-phosphate biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004370	molecular_function	glycerol kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005975	biological_process	carbohydrate metabolic process
D	0006071	biological_process	glycerol metabolic process
D	0006072	biological_process	glycerol-3-phosphate metabolic process
D	0006641	biological_process	triglyceride metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019563	biological_process	glycerol catabolic process
D	0046167	biological_process	glycerol-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 601

Chain	Residue
A	ARG84
A	GLU85
A	TRP104
A	ASP254
A	HOH783

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 602

Chain	Residue
A	GLN255
A	THR273
A	GLY275
A	THR276
A	PHE279
A	HOH758
A	HOH763
A	HOH769
A	HOH941
A	GLY10
A	THR11
A	THR12
A	SER13

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 601

Chain	Residue
B	ARG84
B	GLU85
B	TRP104
B	ASP254
B	GLN255
B	HOH879

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP B 602

Chain	Residue
B	ARG22
B	ARG24
B	ARG477
B	GLU478
B	ADP603
B	MG604
B	HOH826
B	HOH839
B	HOH847
B	HOH932
B	HOH973

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP B 603

Chain	Residue
B	MET1
B	TYR3
B	ASP20
B	ARG22
B	ARG24
B	ADP602
B	MG604
B	HOH723
B	HOH812
B	HOH876
B	HOH884

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 604

Chain	Residue
B	ADP602
B	ADP603
B	HOH876
B	HOH884

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 601

Chain	Residue
C	ARG84
C	GLU85
C	TRP104
C	TYR139
C	ARG192
C	PHE279
C	GLU314

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 602

Chain	Residue
B	ARG199
C	LYS505
C	ARG506

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 603

Chain	Residue
C	PRO25
C	VAL26
C	SER27
C	LYS68

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 601

Chain	Residue
D	ARG84
D	GLU85
D	TRP104
D	ASP254
D	GLN255
D	HOH737
D	HOH792

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP D 602

Chain	Residue
D	MET1
D	TYR3
D	ASP20
D	ARG22
D	ARG24
D	ASP69
D	ADP603
D	MG604
D	HOH725
D	HOH728
D	HOH790
D	HOH820
D	HOH826
D	HOH865
D	HOH913

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP D 603

Chain	Residue
D	HOH902
D	ARG22
D	ARG24
D	ARG477
D	GLU478
D	ADP602
D	MG604
D	HOH728
D	HOH745
D	HOH781
D	HOH793
D	HOH801
D	HOH825
D	HOH867

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 604

Chain	Residue
D	ADP602
D	ADP603
D	HOH728
D	HOH745
D	HOH820
D	HOH865

Functional Information from PROSITE/UniProt

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GtIVGMtlkttra.HVIRAALQ

Chain	Residue	Details
A	GLY373-GLN393

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)