3WXL
Crystal structure of trypanosoma brucei gambiense glycerol kinase complex with adp, mg2+, and glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004370 | molecular_function | glycerol kinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006071 | biological_process | glycerol metabolic process |
| A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| A | 0006641 | biological_process | triglyceride metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
| B | 0004370 | molecular_function | glycerol kinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006071 | biological_process | glycerol metabolic process |
| B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| B | 0006641 | biological_process | triglyceride metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
| C | 0004370 | molecular_function | glycerol kinase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006071 | biological_process | glycerol metabolic process |
| C | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| C | 0006641 | biological_process | triglyceride metabolic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| C | 0019563 | biological_process | glycerol catabolic process |
| C | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
| D | 0004370 | molecular_function | glycerol kinase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006071 | biological_process | glycerol metabolic process |
| D | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| D | 0006641 | biological_process | triglyceride metabolic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| D | 0019563 | biological_process | glycerol catabolic process |
| D | 0046167 | biological_process | glycerol-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | ARG84 |
| A | GLU85 |
| A | TRP104 |
| A | ASP254 |
| A | HOH783 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP A 602 |
| Chain | Residue |
| A | GLN255 |
| A | THR273 |
| A | GLY275 |
| A | THR276 |
| A | PHE279 |
| A | HOH758 |
| A | HOH763 |
| A | HOH769 |
| A | HOH941 |
| A | GLY10 |
| A | THR11 |
| A | THR12 |
| A | SER13 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 601 |
| Chain | Residue |
| B | ARG84 |
| B | GLU85 |
| B | TRP104 |
| B | ASP254 |
| B | GLN255 |
| B | HOH879 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP B 602 |
| Chain | Residue |
| B | ARG22 |
| B | ARG24 |
| B | ARG477 |
| B | GLU478 |
| B | ADP603 |
| B | MG604 |
| B | HOH826 |
| B | HOH839 |
| B | HOH847 |
| B | HOH932 |
| B | HOH973 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP B 603 |
| Chain | Residue |
| B | MET1 |
| B | TYR3 |
| B | ASP20 |
| B | ARG22 |
| B | ARG24 |
| B | ADP602 |
| B | MG604 |
| B | HOH723 |
| B | HOH812 |
| B | HOH876 |
| B | HOH884 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 604 |
| Chain | Residue |
| B | ADP602 |
| B | ADP603 |
| B | HOH876 |
| B | HOH884 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 601 |
| Chain | Residue |
| C | ARG84 |
| C | GLU85 |
| C | TRP104 |
| C | TYR139 |
| C | ARG192 |
| C | PHE279 |
| C | GLU314 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 602 |
| Chain | Residue |
| B | ARG199 |
| C | LYS505 |
| C | ARG506 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 603 |
| Chain | Residue |
| C | PRO25 |
| C | VAL26 |
| C | SER27 |
| C | LYS68 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 601 |
| Chain | Residue |
| D | ARG84 |
| D | GLU85 |
| D | TRP104 |
| D | ASP254 |
| D | GLN255 |
| D | HOH737 |
| D | HOH792 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP D 602 |
| Chain | Residue |
| D | MET1 |
| D | TYR3 |
| D | ASP20 |
| D | ARG22 |
| D | ARG24 |
| D | ASP69 |
| D | ADP603 |
| D | MG604 |
| D | HOH725 |
| D | HOH728 |
| D | HOH790 |
| D | HOH820 |
| D | HOH826 |
| D | HOH865 |
| D | HOH913 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP D 603 |
| Chain | Residue |
| D | HOH902 |
| D | ARG22 |
| D | ARG24 |
| D | ARG477 |
| D | GLU478 |
| D | ADP602 |
| D | MG604 |
| D | HOH728 |
| D | HOH745 |
| D | HOH781 |
| D | HOH793 |
| D | HOH801 |
| D | HOH825 |
| D | HOH867 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 604 |
| Chain | Residue |
| D | ADP602 |
| D | ADP603 |
| D | HOH728 |
| D | HOH745 |
| D | HOH820 |
| D | HOH865 |
Functional Information from PROSITE/UniProt
| site_id | PS00445 |
| Number of Residues | 21 |
| Details | FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GtIVGMtlkttra.HVIRAALQ |
| Chain | Residue | Details |
| A | GLY373-GLN393 |
