Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
| B | 0003756 | molecular_function | protein disulfide isomerase activity |
| C | 0003756 | molecular_function | protein disulfide isomerase activity |
| D | 0003756 | molecular_function | protein disulfide isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | TYR218 |
| A | HIS270 |
| C | SER385 |
| C | GLU386 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 501 |
| Chain | Residue |
| B | TYR218 |
| D | SER385 |
| D | GLU386 |
| D | ALA449 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 501 |
| Chain | Residue |
| C | TYR218 |
| A | GLU386 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 501 |
| Chain | Residue |
| B | SER385 |
| D | TYR218 |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. LIeFYapWCGHCKaLapkY |
| Chain | Residue | Details |
| A | LEU357-TYR375 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS365 | |
| A | CYS368 | |
| B | CYS365 | |
| B | CYS368 | |
| C | CYS365 | |
| C | CYS368 | |
| D | CYS365 | |
| D | CYS368 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Contributes to redox potential value => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY366 | |
| A | HIS367 | |
| B | GLY366 | |
| B | HIS367 | |
| C | GLY366 | |
| C | HIS367 | |
| D | GLY366 | |
| D | HIS367 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Lowers pKa of C-terminal Cys of second active site => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG431 | |
| B | ARG431 | |
| C | ARG431 | |
| D | ARG431 | |
