3WT1

Crystal structure of the b'-a' domain of thermophilic fungal protein disulfide isomerase (reduced form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003756	molecular_function	protein disulfide isomerase activity
B	0003756	molecular_function	protein disulfide isomerase activity
C	0003756	molecular_function	protein disulfide isomerase activity
D	0003756	molecular_function	protein disulfide isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 501

Chain	Residue
A	TYR218
A	HIS270
C	SER385
C	GLU386

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 501

Chain	Residue
B	TYR218
D	SER385
D	GLU386
D	ALA449

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 501

Chain	Residue
C	TYR218
A	GLU386

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL D 501

Chain	Residue
B	SER385
D	TYR218

---

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LIeFYapWCGHCKaLapkY

Chain	Residue	Details
A	LEU357-TYR375

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Domain: {"description":"Thioredoxin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Lowers pKa of C-terminal Cys of second active site","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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