3WST
Crystal structure of C.elegans PRMT7 in complex with SAH(P31)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006479 | biological_process | protein methylation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0006479 | biological_process | protein methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0006479 | biological_process | protein methylation |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0006479 | biological_process | protein methylation |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
| E | 0006479 | biological_process | protein methylation |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| E | 0018216 | biological_process | peptidyl-arginine methylation |
| F | 0006479 | biological_process | protein methylation |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| F | 0018216 | biological_process | peptidyl-arginine methylation |
| G | 0006479 | biological_process | protein methylation |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| G | 0018216 | biological_process | peptidyl-arginine methylation |
| H | 0006479 | biological_process | protein methylation |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| H | 0018216 | biological_process | peptidyl-arginine methylation |
| I | 0006479 | biological_process | protein methylation |
| I | 0008168 | molecular_function | methyltransferase activity |
| I | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| I | 0018216 | biological_process | peptidyl-arginine methylation |
| J | 0006479 | biological_process | protein methylation |
| J | 0008168 | molecular_function | methyltransferase activity |
| J | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| J | 0018216 | biological_process | peptidyl-arginine methylation |
| K | 0006479 | biological_process | protein methylation |
| K | 0008168 | molecular_function | methyltransferase activity |
| K | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| K | 0018216 | biological_process | peptidyl-arginine methylation |
| L | 0006479 | biological_process | protein methylation |
| L | 0008168 | molecular_function | methyltransferase activity |
| L | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| L | 0018216 | biological_process | peptidyl-arginine methylation |
| M | 0006479 | biological_process | protein methylation |
| M | 0008168 | molecular_function | methyltransferase activity |
| M | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| M | 0018216 | biological_process | peptidyl-arginine methylation |
| N | 0006479 | biological_process | protein methylation |
| N | 0008168 | molecular_function | methyltransferase activity |
| N | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| N | 0018216 | biological_process | peptidyl-arginine methylation |
| O | 0006479 | biological_process | protein methylation |
| O | 0008168 | molecular_function | methyltransferase activity |
| O | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| O | 0018216 | biological_process | peptidyl-arginine methylation |
| P | 0006479 | biological_process | protein methylation |
| P | 0008168 | molecular_function | methyltransferase activity |
| P | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| P | 0018216 | biological_process | peptidyl-arginine methylation |
| Q | 0006479 | biological_process | protein methylation |
| Q | 0008168 | molecular_function | methyltransferase activity |
| Q | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| Q | 0018216 | biological_process | peptidyl-arginine methylation |
| R | 0006479 | biological_process | protein methylation |
| R | 0008168 | molecular_function | methyltransferase activity |
| R | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| R | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH A 701 |
| Chain | Residue |
| A | MET36 |
| A | SER123 |
| A | GLU140 |
| A | THR154 |
| A | HOH809 |
| A | ARG42 |
| A | ILE71 |
| A | GLY72 |
| A | THR73 |
| A | LEU78 |
| A | GLU94 |
| A | VAL95 |
| A | ARG122 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 702 |
| Chain | Residue |
| A | SER354 |
| A | ARG355 |
| A | GLN356 |
| A | HOH887 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH D 701 |
| Chain | Residue |
| D | MET36 |
| D | ARG42 |
| D | GLY72 |
| D | THR73 |
| D | LEU78 |
| D | GLU94 |
| D | VAL95 |
| D | GLU121 |
| D | ARG122 |
| D | SER123 |
| D | GLU140 |
| D | THR154 |
| D | HOH816 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 702 |
| Chain | Residue |
| D | SER354 |
| D | ARG355 |
| D | GLN356 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SAH B 701 |
| Chain | Residue |
| B | MET36 |
| B | ARG42 |
| B | ILE71 |
| B | GLY72 |
| B | THR73 |
| B | LEU78 |
| B | GLU94 |
| B | VAL95 |
| B | ARG122 |
| B | SER123 |
| B | GLU140 |
| B | THR154 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 702 |
| Chain | Residue |
| B | SER354 |
| B | ARG355 |
| B | GLN356 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH C 701 |
| Chain | Residue |
| C | MET36 |
| C | ARG42 |
| C | ILE71 |
| C | GLY72 |
| C | THR73 |
| C | LEU78 |
| C | GLU94 |
| C | VAL95 |
| C | GLU121 |
| C | ARG122 |
| C | SER123 |
| C | GLU140 |
| C | THR154 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 C 702 |
| Chain | Residue |
| C | ARG355 |
| C | GLN356 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SAH F 701 |
| Chain | Residue |
| F | MET36 |
| F | ARG42 |
| F | GLY72 |
| F | THR73 |
| F | GLY74 |
| F | LEU78 |
| F | GLU94 |
| F | VAL95 |
| F | ARG122 |
| F | SER123 |
| F | GLU140 |
| F | THR154 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 F 702 |
| Chain | Residue |
| F | SER354 |
| F | ARG355 |
| F | GLN356 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH E 701 |
| Chain | Residue |
| E | PHE33 |
| E | MET36 |
| E | ARG42 |
| E | ILE71 |
| E | GLY72 |
| E | THR73 |
| E | THR75 |
| E | GLU94 |
| E | VAL95 |
| E | ARG122 |
| E | SER123 |
| E | GLU140 |
| E | VAL141 |
| E | THR154 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 E 702 |
| Chain | Residue |
| E | SER354 |
| E | ARG355 |
| E | GLN356 |
| E | HOH839 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH G 701 |
| Chain | Residue |
| G | GLY72 |
| G | THR73 |
| G | GLY74 |
| G | LEU78 |
| G | GLU94 |
| G | VAL95 |
| G | ARG122 |
| G | SER123 |
| G | THR124 |
| G | GLU140 |
| G | THR154 |
| G | MET36 |
| G | ARG42 |
| G | ILE71 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 G 702 |
| Chain | Residue |
| G | SER354 |
| G | ARG355 |
| G | GLN356 |
| G | LYS608 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH H 701 |
| Chain | Residue |
| H | MET36 |
| H | ARG42 |
| H | ILE71 |
| H | GLY72 |
| H | THR73 |
| H | LEU78 |
| H | GLU94 |
| H | VAL95 |
| H | GLU121 |
| H | ARG122 |
| H | SER123 |
| H | GLU140 |
| H | VAL141 |
| H | THR154 |
| H | HOH834 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 H 702 |
| Chain | Residue |
| H | SER354 |
| H | ARG355 |
| H | GLN356 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SAH I 701 |
| Chain | Residue |
| I | MET36 |
| I | ARG42 |
| I | ILE71 |
| I | GLY72 |
| I | THR73 |
| I | LEU78 |
| I | GLU94 |
| I | VAL95 |
| I | ARG122 |
| I | SER123 |
| I | GLU140 |
| I | THR154 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 I 702 |
| Chain | Residue |
| I | SER354 |
| I | ARG355 |
| I | GLN356 |
| site_id | CC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH M 701 |
| Chain | Residue |
| M | ARG42 |
| M | GLY72 |
| M | THR73 |
| M | GLY74 |
| M | THR75 |
| M | LEU78 |
| M | GLU94 |
| M | VAL95 |
| M | GLU121 |
| M | ARG122 |
| M | SER123 |
| M | GLU140 |
| M | THR154 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 M 702 |
| Chain | Residue |
| M | SER354 |
| M | ARG355 |
| M | GLN356 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH N 701 |
| Chain | Residue |
| N | MET36 |
| N | ARG42 |
| N | ILE71 |
| N | GLY72 |
| N | THR73 |
| N | GLY74 |
| N | LEU78 |
| N | LEU93 |
| N | GLU94 |
| N | VAL95 |
| N | ARG122 |
| N | SER123 |
| N | GLU140 |
| N | THR154 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 N 702 |
| Chain | Residue |
| N | SER354 |
| N | ARG355 |
| N | GLN356 |
| site_id | CC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SAH O 701 |
| Chain | Residue |
| O | MET36 |
| O | ARG42 |
| O | GLY72 |
| O | THR73 |
| O | GLU94 |
| O | VAL95 |
| O | ARG122 |
| O | SER123 |
| O | GLU140 |
| O | VAL141 |
| O | THR154 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 O 702 |
| Chain | Residue |
| O | SER354 |
| O | ARG355 |
| O | GLN356 |
| O | LYS608 |
| site_id | CC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SAH P 701 |
| Chain | Residue |
| P | MET36 |
| P | ARG42 |
| P | GLY72 |
| P | THR73 |
| P | GLY74 |
| P | GLU94 |
| P | VAL95 |
| P | GLU121 |
| P | ARG122 |
| P | SER123 |
| P | GLU140 |
| P | THR154 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 P 702 |
| Chain | Residue |
| P | SER354 |
| P | ARG355 |
| P | GLN356 |
| P | HOH805 |
| site_id | CC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH Q 701 |
| Chain | Residue |
| Q | PHE33 |
| Q | MET36 |
| Q | ARG42 |
| Q | ILE71 |
| Q | GLY72 |
| Q | THR73 |
| Q | LEU78 |
| Q | GLU94 |
| Q | VAL95 |
| Q | ARG122 |
| Q | SER123 |
| Q | GLU140 |
| Q | VAL141 |
| Q | THR154 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 Q 702 |
| Chain | Residue |
| Q | SER354 |
| Q | ARG355 |
| Q | GLN356 |
| site_id | DC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SAH R 701 |
| Chain | Residue |
| R | MET36 |
| R | ARG42 |
| R | GLY72 |
| R | THR73 |
| R | GLY74 |
| R | LEU78 |
| R | GLU94 |
| R | VAL95 |
| R | GLU121 |
| R | ARG122 |
| R | SER123 |
| R | THR154 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 R 702 |
| Chain | Residue |
| R | SER354 |
| R | ARG355 |
| R | GLN356 |
| site_id | DC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SAH J 701 |
| Chain | Residue |
| J | ARG42 |
| J | GLY72 |
| J | THR73 |
| J | LEU78 |
| J | GLU94 |
| J | VAL95 |
| J | ARG122 |
| J | SER123 |
| J | GLU140 |
| J | VAL141 |
| J | THR154 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 J 702 |
| Chain | Residue |
| J | SER354 |
| J | ARG355 |
| J | GLN356 |
| site_id | DC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH K 701 |
| Chain | Residue |
| K | PHE33 |
| K | ARG42 |
| K | ILE71 |
| K | GLY72 |
| K | THR73 |
| K | GLY74 |
| K | GLU94 |
| K | VAL95 |
| K | GLU121 |
| K | ARG122 |
| K | SER123 |
| K | GLU140 |
| K | VAL141 |
| K | THR154 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 K 702 |
| Chain | Residue |
| K | SER354 |
| K | ARG355 |
| K | GLN356 |
| site_id | DC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH L 701 |
| Chain | Residue |
| L | MET36 |
| L | ARG42 |
| L | ILE71 |
| L | GLY72 |
| L | THR73 |
| L | LEU78 |
| L | GLU94 |
| L | VAL95 |
| L | ARG122 |
| L | SER123 |
| L | GLU140 |
| L | VAL141 |
| L | THR154 |
| L | HOH866 |
| L | HOH867 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 L 702 |
| Chain | Residue |
| L | SER354 |
| L | ARG355 |
| L | GLN356 |
| L | HOH873 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 960 |
| Details | Domain: {"description":"SAM-dependent MTase PRMT-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
