Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WST

Crystal structure of C.elegans PRMT7 in complex with SAH(P31)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006479	biological_process	protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018216	biological_process	peptidyl-arginine methylation
A	0032259	biological_process	methylation
A	0042054	molecular_function	histone methyltransferase activity
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006479	biological_process	protein methylation
B	0008168	molecular_function	methyltransferase activity
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0018216	biological_process	peptidyl-arginine methylation
B	0032259	biological_process	methylation
B	0042054	molecular_function	histone methyltransferase activity
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006479	biological_process	protein methylation
C	0008168	molecular_function	methyltransferase activity
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0018216	biological_process	peptidyl-arginine methylation
C	0032259	biological_process	methylation
C	0042054	molecular_function	histone methyltransferase activity
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006479	biological_process	protein methylation
D	0008168	molecular_function	methyltransferase activity
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0016740	molecular_function	transferase activity
D	0018216	biological_process	peptidyl-arginine methylation
D	0032259	biological_process	methylation
D	0042054	molecular_function	histone methyltransferase activity
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006479	biological_process	protein methylation
E	0008168	molecular_function	methyltransferase activity
E	0016274	molecular_function	protein-arginine N-methyltransferase activity
E	0016740	molecular_function	transferase activity
E	0018216	biological_process	peptidyl-arginine methylation
E	0032259	biological_process	methylation
E	0042054	molecular_function	histone methyltransferase activity
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006479	biological_process	protein methylation
F	0008168	molecular_function	methyltransferase activity
F	0016274	molecular_function	protein-arginine N-methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0018216	biological_process	peptidyl-arginine methylation
F	0032259	biological_process	methylation
F	0042054	molecular_function	histone methyltransferase activity
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006479	biological_process	protein methylation
G	0008168	molecular_function	methyltransferase activity
G	0016274	molecular_function	protein-arginine N-methyltransferase activity
G	0016740	molecular_function	transferase activity
G	0018216	biological_process	peptidyl-arginine methylation
G	0032259	biological_process	methylation
G	0042054	molecular_function	histone methyltransferase activity
H	0006338	biological_process	chromatin remodeling
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006479	biological_process	protein methylation
H	0008168	molecular_function	methyltransferase activity
H	0016274	molecular_function	protein-arginine N-methyltransferase activity
H	0016740	molecular_function	transferase activity
H	0018216	biological_process	peptidyl-arginine methylation
H	0032259	biological_process	methylation
H	0042054	molecular_function	histone methyltransferase activity
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006479	biological_process	protein methylation
I	0008168	molecular_function	methyltransferase activity
I	0016274	molecular_function	protein-arginine N-methyltransferase activity
I	0016740	molecular_function	transferase activity
I	0018216	biological_process	peptidyl-arginine methylation
I	0032259	biological_process	methylation
I	0042054	molecular_function	histone methyltransferase activity
J	0006338	biological_process	chromatin remodeling
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006479	biological_process	protein methylation
J	0008168	molecular_function	methyltransferase activity
J	0016274	molecular_function	protein-arginine N-methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0018216	biological_process	peptidyl-arginine methylation
J	0032259	biological_process	methylation
J	0042054	molecular_function	histone methyltransferase activity
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006479	biological_process	protein methylation
K	0008168	molecular_function	methyltransferase activity
K	0016274	molecular_function	protein-arginine N-methyltransferase activity
K	0016740	molecular_function	transferase activity
K	0018216	biological_process	peptidyl-arginine methylation
K	0032259	biological_process	methylation
K	0042054	molecular_function	histone methyltransferase activity
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006479	biological_process	protein methylation
L	0008168	molecular_function	methyltransferase activity
L	0016274	molecular_function	protein-arginine N-methyltransferase activity
L	0016740	molecular_function	transferase activity
L	0018216	biological_process	peptidyl-arginine methylation
L	0032259	biological_process	methylation
L	0042054	molecular_function	histone methyltransferase activity
M	0006338	biological_process	chromatin remodeling
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006479	biological_process	protein methylation
M	0008168	molecular_function	methyltransferase activity
M	0016274	molecular_function	protein-arginine N-methyltransferase activity
M	0016740	molecular_function	transferase activity
M	0018216	biological_process	peptidyl-arginine methylation
M	0032259	biological_process	methylation
M	0042054	molecular_function	histone methyltransferase activity
N	0006338	biological_process	chromatin remodeling
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006479	biological_process	protein methylation
N	0008168	molecular_function	methyltransferase activity
N	0016274	molecular_function	protein-arginine N-methyltransferase activity
N	0016740	molecular_function	transferase activity
N	0018216	biological_process	peptidyl-arginine methylation
N	0032259	biological_process	methylation
N	0042054	molecular_function	histone methyltransferase activity
O	0006338	biological_process	chromatin remodeling
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006479	biological_process	protein methylation
O	0008168	molecular_function	methyltransferase activity
O	0016274	molecular_function	protein-arginine N-methyltransferase activity
O	0016740	molecular_function	transferase activity
O	0018216	biological_process	peptidyl-arginine methylation
O	0032259	biological_process	methylation
O	0042054	molecular_function	histone methyltransferase activity
P	0006338	biological_process	chromatin remodeling
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006479	biological_process	protein methylation
P	0008168	molecular_function	methyltransferase activity
P	0016274	molecular_function	protein-arginine N-methyltransferase activity
P	0016740	molecular_function	transferase activity
P	0018216	biological_process	peptidyl-arginine methylation
P	0032259	biological_process	methylation
P	0042054	molecular_function	histone methyltransferase activity
Q	0006338	biological_process	chromatin remodeling
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006479	biological_process	protein methylation
Q	0008168	molecular_function	methyltransferase activity
Q	0016274	molecular_function	protein-arginine N-methyltransferase activity
Q	0016740	molecular_function	transferase activity
Q	0018216	biological_process	peptidyl-arginine methylation
Q	0032259	biological_process	methylation
Q	0042054	molecular_function	histone methyltransferase activity
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006479	biological_process	protein methylation
R	0008168	molecular_function	methyltransferase activity
R	0016274	molecular_function	protein-arginine N-methyltransferase activity
R	0016740	molecular_function	transferase activity
R	0018216	biological_process	peptidyl-arginine methylation
R	0032259	biological_process	methylation
R	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH A 701

Chain	Residue
A	MET36
A	SER123
A	GLU140
A	THR154
A	HOH809
A	ARG42
A	ILE71
A	GLY72
A	THR73
A	LEU78
A	GLU94
A	VAL95
A	ARG122

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 702

Chain	Residue
A	SER354
A	ARG355
A	GLN356
A	HOH887

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH D 701

Chain	Residue
D	MET36
D	ARG42
D	GLY72
D	THR73
D	LEU78
D	GLU94
D	VAL95
D	GLU121
D	ARG122
D	SER123
D	GLU140
D	THR154
D	HOH816

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 D 702

Chain	Residue
D	SER354
D	ARG355
D	GLN356

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH B 701

Chain	Residue
B	MET36
B	ARG42
B	ILE71
B	GLY72
B	THR73
B	LEU78
B	GLU94
B	VAL95
B	ARG122
B	SER123
B	GLU140
B	THR154

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 B 702

Chain	Residue
B	SER354
B	ARG355
B	GLN356

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH C 701

Chain	Residue
C	MET36
C	ARG42
C	ILE71
C	GLY72
C	THR73
C	LEU78
C	GLU94
C	VAL95
C	GLU121
C	ARG122
C	SER123
C	GLU140
C	THR154

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 C 702

Chain	Residue
C	ARG355
C	GLN356

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH F 701

Chain	Residue
F	MET36
F	ARG42
F	GLY72
F	THR73
F	GLY74
F	LEU78
F	GLU94
F	VAL95
F	ARG122
F	SER123
F	GLU140
F	THR154

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 F 702

Chain	Residue
F	SER354
F	ARG355
F	GLN356

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH E 701

Chain	Residue
E	PHE33
E	MET36
E	ARG42
E	ILE71
E	GLY72
E	THR73
E	THR75
E	GLU94
E	VAL95
E	ARG122
E	SER123
E	GLU140
E	VAL141
E	THR154

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 702

Chain	Residue
E	SER354
E	ARG355
E	GLN356
E	HOH839

site_id	BC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH G 701

Chain	Residue
G	GLY72
G	THR73
G	GLY74
G	LEU78
G	GLU94
G	VAL95
G	ARG122
G	SER123
G	THR124
G	GLU140
G	THR154
G	MET36
G	ARG42
G	ILE71

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 G 702

Chain	Residue
G	SER354
G	ARG355
G	GLN356
G	LYS608

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH H 701

Chain	Residue
H	MET36
H	ARG42
H	ILE71
H	GLY72
H	THR73
H	LEU78
H	GLU94
H	VAL95
H	GLU121
H	ARG122
H	SER123
H	GLU140
H	VAL141
H	THR154
H	HOH834

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 H 702

Chain	Residue
H	SER354
H	ARG355
H	GLN356

site_id	BC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH I 701

Chain	Residue
I	MET36
I	ARG42
I	ILE71
I	GLY72
I	THR73
I	LEU78
I	GLU94
I	VAL95
I	ARG122
I	SER123
I	GLU140
I	THR154

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 I 702

Chain	Residue
I	SER354
I	ARG355
I	GLN356

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH M 701

Chain	Residue
M	ARG42
M	GLY72
M	THR73
M	GLY74
M	THR75
M	LEU78
M	GLU94
M	VAL95
M	GLU121
M	ARG122
M	SER123
M	GLU140
M	THR154

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 M 702

Chain	Residue
M	SER354
M	ARG355
M	GLN356

site_id	CC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH N 701

Chain	Residue
N	MET36
N	ARG42
N	ILE71
N	GLY72
N	THR73
N	GLY74
N	LEU78
N	LEU93
N	GLU94
N	VAL95
N	ARG122
N	SER123
N	GLU140
N	THR154

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 N 702

Chain	Residue
N	SER354
N	ARG355
N	GLN356

site_id	CC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SAH O 701

Chain	Residue
O	MET36
O	ARG42
O	GLY72
O	THR73
O	GLU94
O	VAL95
O	ARG122
O	SER123
O	GLU140
O	VAL141
O	THR154

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 O 702

Chain	Residue
O	SER354
O	ARG355
O	GLN356
O	LYS608

site_id	CC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH P 701

Chain	Residue
P	MET36
P	ARG42
P	GLY72
P	THR73
P	GLY74
P	GLU94
P	VAL95
P	GLU121
P	ARG122
P	SER123
P	GLU140
P	THR154

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 P 702

Chain	Residue
P	SER354
P	ARG355
P	GLN356
P	HOH805

site_id	CC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH Q 701

Chain	Residue
Q	PHE33
Q	MET36
Q	ARG42
Q	ILE71
Q	GLY72
Q	THR73
Q	LEU78
Q	GLU94
Q	VAL95
Q	ARG122
Q	SER123
Q	GLU140
Q	VAL141
Q	THR154

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 Q 702

Chain	Residue
Q	SER354
Q	ARG355
Q	GLN356

site_id	DC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH R 701

Chain	Residue
R	MET36
R	ARG42
R	GLY72
R	THR73
R	GLY74
R	LEU78
R	GLU94
R	VAL95
R	GLU121
R	ARG122
R	SER123
R	THR154

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 R 702

Chain	Residue
R	SER354
R	ARG355
R	GLN356

site_id	DC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SAH J 701

Chain	Residue
J	ARG42
J	GLY72
J	THR73
J	LEU78
J	GLU94
J	VAL95
J	ARG122
J	SER123
J	GLU140
J	VAL141
J	THR154

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 J 702

Chain	Residue
J	SER354
J	ARG355
J	GLN356

site_id	DC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAH K 701

Chain	Residue
K	PHE33
K	ARG42
K	ILE71
K	GLY72
K	THR73
K	GLY74
K	GLU94
K	VAL95
K	GLU121
K	ARG122
K	SER123
K	GLU140
K	VAL141
K	THR154

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 K 702

Chain	Residue
K	SER354
K	ARG355
K	GLN356

site_id	DC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH L 701

Chain	Residue
L	MET36
L	ARG42
L	ILE71
L	GLY72
L	THR73
L	LEU78
L	GLU94
L	VAL95
L	ARG122
L	SER123
L	GLU140
L	VAL141
L	THR154
L	HOH866
L	HOH867

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 L 702

Chain	Residue
L	SER354
L	ARG355
L	GLN356
L	HOH873

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	960
Details	Domain: {"description":"SAM-dependent MTase PRMT-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)