3WRX
Crystal structure of helicase complex 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| C | 0005524 | molecular_function | ATP binding |
| D | 0005524 | molecular_function | ATP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE AGS A 501 |
| Chain | Residue |
| A | THR16 |
| A | GLY124 |
| A | SER125 |
| A | GLY126 |
| A | GLY127 |
| A | HOH633 |
| A | HOH662 |
| A | HOH667 |
| A | HOH804 |
| A | HOH805 |
| C | ASP1097 |
| A | ASP18 |
| C | ARG1100 |
| C | VAL1101 |
| A | THR19 |
| A | LYS20 |
| A | SER54 |
| A | THR55 |
| A | SER56 |
| A | ARG92 |
| A | ALA95 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | MET85 |
| A | GLY86 |
| C | ASN978 |
| C | TYR981 |
| C | GLY983 |
| C | HOH1477 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 503 |
| Chain | Residue |
| A | THR271 |
| A | ASP275 |
| A | MET308 |
| A | ASN310 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 504 |
| Chain | Residue |
| A | LEU397 |
| A | ASN400 |
| A | CYS403 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 505 |
| Chain | Residue |
| A | SER76 |
| A | HIS78 |
| A | THR79 |
| A | HOH686 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CS A 506 |
| Chain | Residue |
| A | SER37 |
| A | PHE38 |
| A | SER39 |
| A | ASN40 |
| B | SER37 |
| B | PHE38 |
| B | SER39 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 507 |
| Chain | Residue |
| A | ASN36 |
| A | SER37 |
| A | SER39 |
| A | LYS41 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AGS B 501 |
| Chain | Residue |
| B | THR16 |
| B | ASP18 |
| B | THR19 |
| B | LYS20 |
| B | SER54 |
| B | THR55 |
| B | SER56 |
| B | ARG92 |
| B | GLY124 |
| B | SER125 |
| B | GLY126 |
| B | GLY127 |
| B | HOH619 |
| B | HOH624 |
| B | HOH638 |
| B | HOH730 |
| D | ASP1097 |
| D | ARG1100 |
| D | VAL1101 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B 502 |
| Chain | Residue |
| B | THR271 |
| B | ASP275 |
| B | MET308 |
| B | ASN310 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B 503 |
| Chain | Residue |
| B | LEU397 |
| B | GLU398 |
| B | ASN400 |
| B | CYS403 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS B 504 |
| Chain | Residue |
| B | SER76 |
| B | HIS78 |
| B | THR79 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS B 505 |
| Chain | Residue |
| B | ASN36 |
| B | SER37 |
| B | SER39 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS B 506 |
| Chain | Residue |
| B | MET85 |
| B | GLY86 |
| D | ASN978 |
| D | TYR981 |
| D | GLY983 |
| site_id | BC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE AGS C 1201 |
| Chain | Residue |
| C | ARG1076 |
| C | MG1202 |
| C | HOH1359 |
| C | HOH1376 |
| C | HOH1416 |
| C | HOH1426 |
| C | HOH1438 |
| C | HOH1478 |
| C | HOH1488 |
| D | PHE783 |
| D | HOH1344 |
| C | PRO835 |
| C | GLY836 |
| C | CYS837 |
| C | GLY838 |
| C | LYS839 |
| C | THR840 |
| C | LYS841 |
| C | ARG868 |
| C | LEU967 |
| C | ARG968 |
| C | GLY1044 |
| C | THR1046 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1202 |
| Chain | Residue |
| C | THR840 |
| C | AGS1201 |
| C | HOH1376 |
| C | HOH1416 |
| C | HOH1426 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS C 1203 |
| Chain | Residue |
| C | LEU1013 |
| C | GLY1015 |
| C | HOH1367 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS C 1204 |
| Chain | Residue |
| C | GLU677 |
| C | HIS680 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS C 1205 |
| Chain | Residue |
| C | SER685 |
| C | ILE688 |
| site_id | CC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AGS D 1201 |
| Chain | Residue |
| D | PRO835 |
| D | GLY836 |
| D | CYS837 |
| D | GLY838 |
| D | LYS839 |
| D | THR840 |
| D | LYS841 |
| D | ARG868 |
| D | GLU907 |
| D | LEU967 |
| D | ARG968 |
| D | GLY1044 |
| D | THR1046 |
| D | ARG1076 |
| D | MG1202 |
| D | HOH1323 |
| D | HOH1360 |
| D | HOH1362 |
| D | HOH1387 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 1202 |
| Chain | Residue |
| D | THR840 |
| D | AGS1201 |
| D | HOH1323 |
| D | HOH1360 |
| D | HOH1362 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS D 1203 |
| Chain | Residue |
| D | GLU799 |
| D | VAL802 |
| D | SER804 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS D 1204 |
| Chain | Residue |
| D | SER685 |
| D | ILE688 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS D 1205 |
| Chain | Residue |
| D | SER825 |
| D | ALA826 |
| D | ASP958 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS D 1206 |
| Chain | Residue |
| D | LEU844 |
| D | VAL847 |
| D | CS1207 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS D 1207 |
| Chain | Residue |
| D | ARG846 |
| D | VAL847 |
| D | CS1206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 220 |
| Details | Region: {"description":"N-terminal inhibitory domain NC","evidences":[{"source":"PubMed","id":"25092327","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25092327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WRY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 324 |
| Details | Domain: {"description":"(+)RNA virus helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 510 |
| Details | Region: {"description":"Helicase"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25092327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WRY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
