3WPH
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001817 | biological_process | regulation of cytokine production |
| A | 0002237 | biological_process | response to molecule of bacterial origin |
| A | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0016021 | cellular_component | integral component of membrane |
| A | 0034162 | biological_process | toll-like receptor 9 signaling pathway |
| A | 0045087 | biological_process | innate immune response |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 792 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU26-ASP818 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q2EEY0 |
| Chain | Residue | Details |
| A | LYS95 | |
| A | TYR132 | |
| A | TYR179 | |
| A | TYR208 | |
| A | TRP47 | |
| A | SER72 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q9NR96 |
| Chain | Residue | Details |
| A | CYS258 | |
| A | CYS265 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN64 | |
| A | ASN514 | |
| A | GLN568 | |
| A | ASN670 | |
| A | GLN695 | |
| A | ASN700 | |
| A | GLN752 | |
| A | ASN129 | |
| A | ASN147 | |
| A | GLN200 | |
| A | GLN242 | |
| A | ASN300 | |
| A | GLN309 | |
| A | ASN340 | |
| A | GLN495 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:25686612, ECO:0007744|PDB:3WPF |
| Chain | Residue | Details |
| A | ASN210 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:25686612, ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPH |
| Chain | Residue | Details |
| A | ASN332 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:25686612, ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPG, ECO:0007744|PDB:3WPH, ECO:0007744|PDB:3WPI |
| Chain | Residue | Details |
| A | ASN732 |
