3WO4

Crystal structure of the IL-18 signaling ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
B	0004908	molecular_function	interleukin-1 receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	174
Details	Domain: {"description":"Ig-like C2-type 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	181
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	92
Details	Domain: {"description":"Ig-like C2-type 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25500532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WO3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25261253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WO3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WO4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25500532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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