3WLV
Thermostable urate oxidase from Bacillus sp. TB-90
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004846 | molecular_function | urate oxidase activity |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0004846 | molecular_function | urate oxidase activity |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| C | 0004846 | molecular_function | urate oxidase activity |
| C | 0006144 | biological_process | purine nucleobase metabolic process |
| D | 0004846 | molecular_function | urate oxidase activity |
| D | 0006144 | biological_process | purine nucleobase metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AZA A 401 |
| Chain | Residue |
| A | PHE184 |
| A | HOH638 |
| B | TYR11 |
| B | ALA72 |
| B | THR73 |
| A | LEU195 |
| A | ARG201 |
| A | SER248 |
| A | ILE249 |
| A | GLN250 |
| A | ASN276 |
| A | CL403 |
| A | HOH522 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | ARG298 |
| C | ARG298 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 403 |
| Chain | Residue |
| A | ASN276 |
| A | GLY302 |
| A | GLN304 |
| A | AZA401 |
| B | THR73 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AZA B 401 |
| Chain | Residue |
| A | ALA72 |
| A | THR73 |
| B | PHE184 |
| B | ARG201 |
| B | SER248 |
| B | ILE249 |
| B | GLN250 |
| B | ASN276 |
| B | CL404 |
| B | HOH510 |
| B | HOH762 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | ARG298 |
| D | ARG298 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 403 |
| Chain | Residue |
| B | ILE32 |
| B | SER35 |
| B | SER38 |
| B | HOH538 |
| C | ARG133 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| Chain | Residue |
| A | THR73 |
| B | ASN276 |
| B | GLY302 |
| B | GLN304 |
| B | AZA401 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AZA C 401 |
| Chain | Residue |
| C | PHE184 |
| C | ARG201 |
| C | SER248 |
| C | ILE249 |
| C | GLN250 |
| C | ASN276 |
| C | CL403 |
| C | HOH631 |
| D | ALA72 |
| D | THR73 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 402 |
| Chain | Residue |
| B | ARG133 |
| C | ILE32 |
| C | SER35 |
| C | SER38 |
| C | HOH527 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 403 |
| Chain | Residue |
| C | ASN276 |
| C | GLY302 |
| C | GLN304 |
| C | AZA401 |
| D | THR73 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AZA D 401 |
| Chain | Residue |
| C | ALA72 |
| C | THR73 |
| D | PHE184 |
| D | LEU195 |
| D | ARG201 |
| D | SER248 |
| D | ILE249 |
| D | GLN250 |
| D | ASN276 |
| D | CL402 |
| D | HOH565 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 402 |
| Chain | Residue |
| C | THR73 |
| D | ASN276 |
| D | GLY302 |
| D | GLN304 |
| D | AZA401 |
Functional Information from PROSITE/UniProt
| site_id | PS00366 |
| Number of Residues | 28 |
| Details | URICASE Uricase signature. LqLIKVSgNsFvgFirdeYttLpedsnR |
| Chain | Residue | Details |
| A | LEU174-ARG201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Charge relay system; for urate oxidase activity","evidences":[{"source":"UniProtKB","id":"D0VWQ1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of urate oxidase from Bacillus sp.","authoringGroup":["Mycobacterium tuberculosis structural genomics consortium (TB)"]}}]} |
| Chain | Residue | Details |
