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3WJA

The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004470molecular_functionmalic enzyme activity
A0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006090biological_processpyruvate metabolic process
A0006108biological_processmalate metabolic process
A0006734biological_processNADH metabolic process
A0006739biological_processNADP metabolic process
A0008948molecular_functionoxaloacetate decarboxylase activity
A0009055molecular_functionelectron transfer activity
A0009165biological_processnucleotide biosynthetic process
A0009725biological_processresponse to hormone
A0009743biological_processresponse to carbohydrate
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0030145molecular_functionmanganese ion binding
A0042802molecular_functionidentical protein binding
A0043531molecular_functionADP binding
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
A0051287molecular_functionNAD binding
A0051289biological_processprotein homotetramerization
A1902031biological_processregulation of NADP metabolic process
B0000287molecular_functionmagnesium ion binding
B0004470molecular_functionmalic enzyme activity
B0004473molecular_functionmalate dehydrogenase (decarboxylating) (NADP+) activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006090biological_processpyruvate metabolic process
B0006108biological_processmalate metabolic process
B0006734biological_processNADH metabolic process
B0006739biological_processNADP metabolic process
B0008948molecular_functionoxaloacetate decarboxylase activity
B0009055molecular_functionelectron transfer activity
B0009165biological_processnucleotide biosynthetic process
B0009725biological_processresponse to hormone
B0009743biological_processresponse to carbohydrate
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0030145molecular_functionmanganese ion binding
B0042802molecular_functionidentical protein binding
B0043531molecular_functionADP binding
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
B0051287molecular_functionNAD binding
B0051289biological_processprotein homotetramerization
B1902031biological_processregulation of NADP metabolic process
Functional Information from PROSITE/UniProt
site_idPS00331
Number of Residues17
DetailsMALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGLL
ChainResidueDetails
APHE276-LEU292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P23368
ChainResidueDetails
ATYR112
BTYR112

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P23368
ChainResidueDetails
ALYS183
BLYS183

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG165
AASP279
AGLY311
AASN418
BARG165
BASP279
BGLY311
BASN418

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P23368
ChainResidueDetails
AGLU255
AASP256
BGLU255
BASP256

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for activity => ECO:0000250
ChainResidueDetails
AASP279
BASP279

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AMET11
BMET11

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06801
ChainResidueDetails
ASER346
BSER346

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PDB entries from 2024-07-24

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