3WHC

Crystal structure of a transcriptional regulator FadR from Bacillus subtilis in complex with stearoyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0016042	biological_process	lipid catabolic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0016042	biological_process	lipid catabolic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0016042	biological_process	lipid catabolic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0016042	biological_process	lipid catabolic process
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005737	cellular_component	cytoplasm
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0016042	biological_process	lipid catabolic process
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005737	cellular_component	cytoplasm
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0016042	biological_process	lipid catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ST9 A 201

Chain	Residue
A	LEU57
A	LEU127
A	ARG150
A	ARG153
A	HOH307
B	GLU162
B	THR165
B	THR166
B	MET169
B	ASN170
B	LYS173
A	LYS61
B	TYR174
B	LEU179
A	HIS90
A	LEU93
A	THR104
A	ARG109
A	ARG116
A	ASN120
A	LYS124

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ST9 B 201

Chain	Residue
A	GLU162
A	THR165
A	THR166
A	MET169
A	ASN170
A	LYS173
A	TYR174
A	LEU179
A	HOH332
A	HOH333
B	LEU57
B	PHE65
B	HIS90
B	THR104
B	ARG109
B	ARG116
B	ASN120
B	LYS124
B	LEU127
B	ARG150
B	ARG153

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ST9 C 201

Chain	Residue
C	LYS61
C	HIS90
C	VAL103
C	THR104
C	ARG109
C	ARG116
C	ASN120
C	LYS124
C	LEU127
C	ARG150
C	LEU151
C	ARG153
C	GLN154
C	PHE157
D	GLU162
D	THR165
D	THR166
D	MET169
D	ASN170
D	TYR174
D	LEU179

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ST9 D 201

Chain	Residue
C	GLU162
C	THR165
C	THR166
C	MET169
C	ASN170
C	LYS173
C	TYR174
C	LEU179
D	PHE58
D	LYS61
D	PHE65
D	HIS90
D	THR104
D	ARG109
D	ARG116
D	ASN120
D	LYS124
D	LEU127
D	ARG150
D	LEU151
D	ARG153
D	GLN154
D	PHE157

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ST9 E 201

Chain	Residue
F	GLU162
F	THR165
F	THR166
F	MET169
F	ASN170
F	LYS173
F	TYR174
F	LEU179
A	LYS76
E	PHE58
E	LYS61
E	MET62
E	HIS90
E	LEU100
E	THR104
E	ARG109
E	ARG116
E	ASN120
E	LEU127
E	ARG150
E	ARG153

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ST9 F 201

Chain	Residue
A	LYS7
A	GLN10
A	GLY37
E	GLU162
E	THR165
E	THR166
E	MET169
E	ASN170
E	TYR174
F	LYS61
F	HIS90
F	LEU93
F	LEU100
F	THR104
F	LEU108
F	ARG109
F	ARG116
F	ASN120
F	LYS124
F	LEU127
F	ARG150
F	ARG153
F	GLN154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	GLN28-PHE47
B	GLN28-PHE47
C	GLN28-PHE47
D	GLN28-PHE47
E	GLN28-PHE47
F	GLN28-PHE47

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