Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009060 | biological_process | aerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016966 | molecular_function | nitric oxide reductase activity |
| B | 0019333 | biological_process | denitrification pathway |
| B | 0020037 | molecular_function | heme binding |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM B 801 |
| Chain | Residue |
| B | GLN30 |
| B | PHE136 |
| B | ALA345 |
| B | HIS349 |
| B | PHE352 |
| B | TYR353 |
| B | MET397 |
| B | ARG440 |
| B | GLU441 |
| B | PHE447 |
| B | HEM802 |
| B | ILE31 |
| B | CA805 |
| C | ALA72 |
| C | TYR73 |
| C | PHE74 |
| B | GLY34 |
| B | MET37 |
| B | TYR41 |
| B | ARG57 |
| B | HIS60 |
| B | LEU64 |
| B | GLU135 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE HEM B 802 |
| Chain | Residue |
| B | GLU135 |
| B | PHE136 |
| B | TRP203 |
| B | VAL210 |
| B | GLU211 |
| B | HIS258 |
| B | HIS259 |
| B | GLU280 |
| B | PHE284 |
| B | ALA322 |
| B | GLY326 |
| B | PHE327 |
| B | HIS329 |
| B | THR330 |
| B | ASN335 |
| B | HIS339 |
| B | GLY340 |
| B | THR344 |
| B | HIS347 |
| B | ALA351 |
| B | PHE352 |
| B | HEM801 |
| B | CL804 |
| B | CA805 |
| B | HOH924 |
| C | HOH302 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE B 803 |
| Chain | Residue |
| B | HIS207 |
| B | GLU211 |
| B | HIS258 |
| B | HIS259 |
| B | CL804 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 804 |
| Chain | Residue |
| B | GLU211 |
| B | HIS259 |
| B | HEM802 |
| B | FE803 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 805 |
| Chain | Residue |
| B | ARG57 |
| B | GLU135 |
| B | HEM801 |
| B | HEM802 |
| C | GLY71 |
| C | TYR73 |
| C | HOH302 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC C 201 |
| Chain | Residue |
| B | ASN54 |
| C | ASN59 |
| C | CYS61 |
| C | CYS64 |
| C | HIS65 |
| C | ALA75 |
| C | PRO76 |
| C | LEU78 |
| C | VAL81 |
| C | ARG84 |
| C | ARG85 |
| C | TRP98 |
| C | MET99 |
| C | ARG109 |
| C | ARG110 |
| C | MET112 |
| C | PRO113 |
| C | PHE115 |
| C | LEU125 |
| C | HOH310 |
| C | HOH312 |
| C | HOH321 |
| C | HOH322 |
| C | HOH324 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 57 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WWVVHLwVegvwelimgailafvlvkitgvdreviekwlyviiamalisgiigtgHH |
| Chain | Residue | Details |
| B | TRP203-HIS259 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Signal-anchor => ECO:0000255 |
| Chain | Residue | Details |
| C | ILE13-THR29 | |
| B | HIS349-PRO369 | |
| B | TRP391-GLN411 | |
| B | ALA434-TYR454 | |
| B | THR61-PRO81 | |
| B | TRP95-VAL115 | |
| B | ILE142-VAL162 | |
| B | ALA169-PHE189 | |
| B | VAL205-VAL225 | |
| B | VAL243-ILE263 | |
| B | LEU270-PHE290 | |
| B | ALA308-MET328 | |
| Chain | Residue | Details |
| C | CYS61 | |
| C | CYS64 | |
| B | MET350 | |
| Chain | Residue | Details |
| C | HIS65 | |
| B | HIS258 | |
| B | HIS259 | |
