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3WCY

Murine Ifnar1 in complex with interferon-beta

Functional Information from GO Data
ChainGOidnamespacecontents
I0002250biological_processadaptive immune response
I0002281biological_processmacrophage activation involved in immune response
I0002286biological_processT cell activation involved in immune response
I0002323biological_processnatural killer cell activation involved in immune response
I0002638biological_processnegative regulation of immunoglobulin production
I0005125molecular_functioncytokine activity
I0005126molecular_functioncytokine receptor binding
I0005132molecular_functiontype I interferon receptor binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0006952biological_processdefense response
I0006959biological_processhumoral immune response
I0008285biological_processnegative regulation of cell population proliferation
I0010508biological_processpositive regulation of autophagy
I0019221biological_processcytokine-mediated signaling pathway
I0030183biological_processB cell differentiation
I0032689biological_processnegative regulation of type II interferon production
I0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
I0042100biological_processB cell proliferation
I0042742biological_processdefense response to bacterium
I0043330biological_processresponse to exogenous dsRNA
I0045671biological_processnegative regulation of osteoclast differentiation
I0051607biological_processdefense response to virus
I0060337biological_processtype I interferon-mediated signaling pathway
I0060354biological_processnegative regulation of cell adhesion molecule production
I0070050biological_processneuron cellular homeostasis
I0071359biological_processcellular response to dsRNA
I0071549biological_processcellular response to dexamethasone stimulus
I0071636biological_processpositive regulation of transforming growth factor beta production
I0071676biological_processnegative regulation of mononuclear cell migration
I0098586biological_processcellular response to virus
I0140123biological_processnegative regulation of Lewy body formation
I0150079biological_processnegative regulation of neuroinflammatory response
I1904465biological_processnegative regulation of matrix metallopeptidase secretion
I1905604biological_processnegative regulation of blood-brain barrier permeability
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YYwRVqrYLklmkynsYAW
ChainResidueDetails
ITYR120-TRP138

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P70499
ChainResidueDetails
ITYR3

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3360010
ChainResidueDetails
IASN29
IASN69
IASN76
AASN188
AASN288
AASN344
AASN383
AASN387

221051

PDB entries from 2024-06-12

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