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3WCY

Murine Ifnar1 in complex with interferon-beta

Functional Information from GO Data
ChainGOidnamespacecontents
I0002250biological_processadaptive immune response
I0002281biological_processmacrophage activation involved in immune response
I0002286biological_processT cell activation involved in immune response
I0002312biological_processB cell activation involved in immune response
I0002323biological_processnatural killer cell activation involved in immune response
I0002638biological_processnegative regulation of immunoglobulin production
I0002683biological_processnegative regulation of immune system process
I0005125molecular_functioncytokine activity
I0005126molecular_functioncytokine receptor binding
I0005132molecular_functiontype I interferon receptor binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0006357biological_processregulation of transcription by RNA polymerase II
I0006952biological_processdefense response
I0006955biological_processimmune response
I0006959biological_processhumoral immune response
I0007165biological_processsignal transduction
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008285biological_processnegative regulation of cell population proliferation
I0008811molecular_functionchloramphenicol O-acetyltransferase activity
I0009893biological_processpositive regulation of metabolic process
I0010508biological_processpositive regulation of autophagy
I0019221biological_processcytokine-mediated signaling pathway
I0032689biological_processnegative regulation of type II interferon production
I0035458biological_processcellular response to interferon-beta
I0042100biological_processB cell proliferation
I0042742biological_processdefense response to bacterium
I0043330biological_processresponse to exogenous dsRNA
I0045071biological_processnegative regulation of viral genome replication
I0045087biological_processinnate immune response
I0045321biological_processleukocyte activation
I0045581biological_processnegative regulation of T cell differentiation
I0045671biological_processnegative regulation of osteoclast differentiation
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0051241biological_processnegative regulation of multicellular organismal process
I0051607biological_processdefense response to virus
I0060337biological_processtype I interferon-mediated signaling pathway
I0060354biological_processnegative regulation of cell adhesion molecule production
I0070050biological_processneuron cellular homeostasis
I0071359biological_processcellular response to dsRNA
I0071549biological_processcellular response to dexamethasone stimulus
I0071636biological_processpositive regulation of transforming growth factor beta production
I0071676biological_processnegative regulation of mononuclear cell migration
I0097696biological_processcell surface receptor signaling pathway via STAT
I0098586biological_processcellular response to virus
I0140123biological_processnegative regulation of Lewy body formation
I0140374biological_processantiviral innate immune response
I0150079biological_processnegative regulation of neuroinflammatory response
I1900182biological_processpositive regulation of protein localization to nucleus
I1904465biological_processnegative regulation of matrix metallopeptidase secretion
I1905604biological_processnegative regulation of blood-brain barrier permeability
I2000552biological_processnegative regulation of T-helper 2 cell cytokine production
I2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YYwRVqrYLklmkynsYAW
ChainResidueDetails
ITYR120-TRP138

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues99
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P70499","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3360010","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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