3WBW
Crystal structure of Gox0644 in complex with NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0050580 | molecular_function | 2,5-didehydrogluconate reductase activity |
| A | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0050580 | molecular_function | 2,5-didehydrogluconate reductase activity |
| B | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | TRP30 |
| A | ARG192 |
| A | HOH511 |
| A | HOH514 |
| A | HOH577 |
| B | HIS20 |
| B | THR21 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP A 302 |
| Chain | Residue |
| A | HIS112 |
| A | SER143 |
| A | ASN144 |
| A | GLN165 |
| A | TRP191 |
| A | ARG192 |
| A | PRO193 |
| A | LEU194 |
| A | GLY195 |
| A | LYS196 |
| A | LEU200 |
| A | ALA217 |
| A | PRO233 |
| A | LYS234 |
| A | SER235 |
| A | VAL236 |
| A | ASN237 |
| A | ARG240 |
| A | GLU243 |
| A | ASN244 |
| A | HOH567 |
| A | GLY28 |
| A | VAL29 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| A | HIS20 |
| A | THR21 |
| B | TRP30 |
| B | ARG192 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP B 302 |
| Chain | Residue |
| B | GLY28 |
| B | TRP30 |
| B | TYR58 |
| B | HIS112 |
| B | TRP113 |
| B | SER143 |
| B | ASN144 |
| B | GLN165 |
| B | TRP191 |
| B | ARG192 |
| B | PRO193 |
| B | LEU194 |
| B | GLY195 |
| B | LYS196 |
| B | LEU200 |
| B | ALA217 |
| B | LYS234 |
| B | SER235 |
| B | VAL236 |
| B | ARG240 |
| B | GLU243 |
| B | ASN244 |
| B | HOH445 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LvelkksgrVKSIGVSNF |
| Chain | Residue | Details |
| A | LEU128-PHE145 |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVNpkRLaENlDV |
| Chain | Residue | Details |
| A | ILE232-VAL247 |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRSVDTArlyknEegVG |
| Chain | Residue | Details |
| A | GLY48-GLY65 |
