Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WBG

Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid transporter activity
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0008092	molecular_function	cytoskeletal protein binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008289	molecular_function	lipid binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0015909	biological_process	long-chain fatty acid transport
A	0016528	cellular_component	sarcoplasm
A	0019433	biological_process	triglyceride catabolic process
A	0032365	biological_process	intracellular lipid transport
A	0032868	biological_process	response to insulin
A	0036041	molecular_function	long-chain fatty acid binding
A	0042632	biological_process	cholesterol homeostasis
A	0046320	biological_process	regulation of fatty acid oxidation
A	0050543	molecular_function	icosatetraenoic acid binding
A	0055091	biological_process	phospholipid homeostasis
A	0070062	cellular_component	extracellular exosome
A	0070538	molecular_function	oleic acid binding
A	0070542	biological_process	response to fatty acid
A	0071073	biological_process	positive regulation of phospholipid biosynthetic process
A	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
B	0005319	molecular_function	lipid transporter activity
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0008092	molecular_function	cytoskeletal protein binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0008289	molecular_function	lipid binding
B	0009410	biological_process	response to xenobiotic stimulus
B	0015909	biological_process	long-chain fatty acid transport
B	0016528	cellular_component	sarcoplasm
B	0019433	biological_process	triglyceride catabolic process
B	0032365	biological_process	intracellular lipid transport
B	0032868	biological_process	response to insulin
B	0036041	molecular_function	long-chain fatty acid binding
B	0042632	biological_process	cholesterol homeostasis
B	0046320	biological_process	regulation of fatty acid oxidation
B	0050543	molecular_function	icosatetraenoic acid binding
B	0055091	biological_process	phospholipid homeostasis
B	0070062	cellular_component	extracellular exosome
B	0070538	molecular_function	oleic acid binding
B	0070542	biological_process	response to fatty acid
B	0071073	biological_process	positive regulation of phospholipid biosynthetic process
B	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
C	0005319	molecular_function	lipid transporter activity
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006631	biological_process	fatty acid metabolic process
C	0008092	molecular_function	cytoskeletal protein binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008289	molecular_function	lipid binding
C	0009410	biological_process	response to xenobiotic stimulus
C	0015909	biological_process	long-chain fatty acid transport
C	0016528	cellular_component	sarcoplasm
C	0019433	biological_process	triglyceride catabolic process
C	0032365	biological_process	intracellular lipid transport
C	0032868	biological_process	response to insulin
C	0036041	molecular_function	long-chain fatty acid binding
C	0042632	biological_process	cholesterol homeostasis
C	0046320	biological_process	regulation of fatty acid oxidation
C	0050543	molecular_function	icosatetraenoic acid binding
C	0055091	biological_process	phospholipid homeostasis
C	0070062	cellular_component	extracellular exosome
C	0070538	molecular_function	oleic acid binding
C	0070542	biological_process	response to fatty acid
C	0071073	biological_process	positive regulation of phospholipid biosynthetic process
C	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
D	0005319	molecular_function	lipid transporter activity
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006631	biological_process	fatty acid metabolic process
D	0008092	molecular_function	cytoskeletal protein binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0008289	molecular_function	lipid binding
D	0009410	biological_process	response to xenobiotic stimulus
D	0015909	biological_process	long-chain fatty acid transport
D	0016528	cellular_component	sarcoplasm
D	0019433	biological_process	triglyceride catabolic process
D	0032365	biological_process	intracellular lipid transport
D	0032868	biological_process	response to insulin
D	0036041	molecular_function	long-chain fatty acid binding
D	0042632	biological_process	cholesterol homeostasis
D	0046320	biological_process	regulation of fatty acid oxidation
D	0050543	molecular_function	icosatetraenoic acid binding
D	0055091	biological_process	phospholipid homeostasis
D	0070062	cellular_component	extracellular exosome
D	0070538	molecular_function	oleic acid binding
D	0070542	biological_process	response to fatty acid
D	0071073	biological_process	positive regulation of phospholipid biosynthetic process
D	0140214	biological_process	positive regulation of long-chain fatty acid import into cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2AN A 201

Chain	Residue
A	TYR19
A	LEU23
A	ALA33
A	THR36
A	SER55
A	ASP76
A	HOH334
A	HOH336

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 2AN B 201

Chain	Residue
B	ALA33
B	SER55
B	ASP76
B	ARG78
B	HOH344
B	LEU23

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 2AN C 201

Chain	Residue
C	SER55
C	LYS58
C	ALA75
C	ARG126

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 2AN D 201

Chain	Residue
D	SER55
D	ARG126
D	HOH334

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWkLvdSkNFDdYMKSL

Chain	Residue	Details
A	GLY6-LEU23

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7922029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HMT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)