3W9T

pore-forming CEL-III

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001906	biological_process	cell killing
A	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
A	0005509	molecular_function	calcium ion binding
A	0005534	molecular_function	galactose binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005794	cellular_component	Golgi apparatus
A	0006493	biological_process	protein O-linked glycosylation
A	0019731	biological_process	antibacterial humoral response
A	0030246	molecular_function	carbohydrate binding
A	0030395	molecular_function	lactose binding
A	0031640	biological_process	killing of cells of another organism
A	0034120	biological_process	positive regulation of erythrocyte aggregation
A	0042742	biological_process	defense response to bacterium
A	0042806	molecular_function	fucose binding
A	0044179	biological_process	hemolysis in another organism
A	0046871	molecular_function	N-acetylgalactosamine binding
A	0046872	molecular_function	metal ion binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051260	biological_process	protein homooligomerization
A	0051673	biological_process	disruption of plasma membrane integrity in another organism
A	1903777	molecular_function	melibiose binding
B	0000287	molecular_function	magnesium ion binding
B	0001906	biological_process	cell killing
B	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
B	0005509	molecular_function	calcium ion binding
B	0005534	molecular_function	galactose binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0006493	biological_process	protein O-linked glycosylation
B	0019731	biological_process	antibacterial humoral response
B	0030246	molecular_function	carbohydrate binding
B	0030395	molecular_function	lactose binding
B	0031640	biological_process	killing of cells of another organism
B	0034120	biological_process	positive regulation of erythrocyte aggregation
B	0042742	biological_process	defense response to bacterium
B	0042806	molecular_function	fucose binding
B	0044179	biological_process	hemolysis in another organism
B	0046871	molecular_function	N-acetylgalactosamine binding
B	0046872	molecular_function	metal ion binding
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0051260	biological_process	protein homooligomerization
B	0051673	biological_process	disruption of plasma membrane integrity in another organism
B	1903777	molecular_function	melibiose binding
C	0000287	molecular_function	magnesium ion binding
C	0001906	biological_process	cell killing
C	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
C	0005509	molecular_function	calcium ion binding
C	0005534	molecular_function	galactose binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005794	cellular_component	Golgi apparatus
C	0006493	biological_process	protein O-linked glycosylation
C	0019731	biological_process	antibacterial humoral response
C	0030246	molecular_function	carbohydrate binding
C	0030395	molecular_function	lactose binding
C	0031640	biological_process	killing of cells of another organism
C	0034120	biological_process	positive regulation of erythrocyte aggregation
C	0042742	biological_process	defense response to bacterium
C	0042806	molecular_function	fucose binding
C	0044179	biological_process	hemolysis in another organism
C	0046871	molecular_function	N-acetylgalactosamine binding
C	0046872	molecular_function	metal ion binding
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051260	biological_process	protein homooligomerization
C	0051673	biological_process	disruption of plasma membrane integrity in another organism
C	1903777	molecular_function	melibiose binding
D	0000287	molecular_function	magnesium ion binding
D	0001906	biological_process	cell killing
D	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
D	0005509	molecular_function	calcium ion binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0006493	biological_process	protein O-linked glycosylation
D	0019731	biological_process	antibacterial humoral response
D	0030246	molecular_function	carbohydrate binding
D	0030395	molecular_function	lactose binding
D	0031640	biological_process	killing of cells of another organism
D	0034120	biological_process	positive regulation of erythrocyte aggregation
D	0042742	biological_process	defense response to bacterium
D	0042806	molecular_function	fucose binding
D	0044179	biological_process	hemolysis in another organism
D	0046871	molecular_function	N-acetylgalactosamine binding
D	0046872	molecular_function	metal ion binding
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0051260	biological_process	protein homooligomerization
D	0051673	biological_process	disruption of plasma membrane integrity in another organism
D	1903777	molecular_function	melibiose binding
E	0000287	molecular_function	magnesium ion binding
E	0001906	biological_process	cell killing
E	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
E	0005509	molecular_function	calcium ion binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005794	cellular_component	Golgi apparatus
E	0006493	biological_process	protein O-linked glycosylation
E	0019731	biological_process	antibacterial humoral response
E	0030246	molecular_function	carbohydrate binding
E	0030395	molecular_function	lactose binding
E	0031640	biological_process	killing of cells of another organism
E	0034120	biological_process	positive regulation of erythrocyte aggregation
E	0042742	biological_process	defense response to bacterium
E	0042806	molecular_function	fucose binding
E	0044179	biological_process	hemolysis in another organism
E	0046871	molecular_function	N-acetylgalactosamine binding
E	0046872	molecular_function	metal ion binding
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0051260	biological_process	protein homooligomerization
E	0051673	biological_process	disruption of plasma membrane integrity in another organism
E	1903777	molecular_function	melibiose binding
F	0000287	molecular_function	magnesium ion binding
F	0001906	biological_process	cell killing
F	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
F	0005509	molecular_function	calcium ion binding
F	0005534	molecular_function	galactose binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005794	cellular_component	Golgi apparatus
F	0006493	biological_process	protein O-linked glycosylation
F	0019731	biological_process	antibacterial humoral response
F	0030246	molecular_function	carbohydrate binding
F	0030395	molecular_function	lactose binding
F	0031640	biological_process	killing of cells of another organism
F	0034120	biological_process	positive regulation of erythrocyte aggregation
F	0042742	biological_process	defense response to bacterium
F	0042806	molecular_function	fucose binding
F	0044179	biological_process	hemolysis in another organism
F	0046871	molecular_function	N-acetylgalactosamine binding
F	0046872	molecular_function	metal ion binding
F	0050829	biological_process	defense response to Gram-negative bacterium
F	0050830	biological_process	defense response to Gram-positive bacterium
F	0051260	biological_process	protein homooligomerization
F	0051673	biological_process	disruption of plasma membrane integrity in another organism
F	1903777	molecular_function	melibiose binding
G	0000287	molecular_function	magnesium ion binding
G	0001906	biological_process	cell killing
G	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
G	0005509	molecular_function	calcium ion binding
G	0005534	molecular_function	galactose binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005794	cellular_component	Golgi apparatus
G	0006493	biological_process	protein O-linked glycosylation
G	0019731	biological_process	antibacterial humoral response
G	0030246	molecular_function	carbohydrate binding
G	0030395	molecular_function	lactose binding
G	0031640	biological_process	killing of cells of another organism
G	0034120	biological_process	positive regulation of erythrocyte aggregation
G	0042742	biological_process	defense response to bacterium
G	0042806	molecular_function	fucose binding
G	0044179	biological_process	hemolysis in another organism
G	0046871	molecular_function	N-acetylgalactosamine binding
G	0046872	molecular_function	metal ion binding
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0051260	biological_process	protein homooligomerization
G	0051673	biological_process	disruption of plasma membrane integrity in another organism
G	1903777	molecular_function	melibiose binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	518
Details	Domain: {"description":"Ricin B-type lectin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	910
Details	Domain: {"description":"Ricin B-type lectin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	224
Details	Domain: {"description":"Ricin B-type lectin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2051
Details	Region: {"description":"Has hemagglutinating activity towards rabbit erythrocytes, but no hemolytic activity towards them","evidences":[{"source":"PubMed","id":"19420692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	77
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	210
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15194688","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1VCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	126
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"10561549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15194688","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---